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European Radiology
Erschienen in:

15.01.2024 | Neuro

Choroid plexus enlargement in mild cognitive impairment on MRI: a large cohort study

verfasst von: Yoshihito Umemura, Keita Watanabe, Sera Kasai, Satoru Ide, Yuka Ishimoto, Miho Sasaki, Haruka Nagaya, Soichiro Tatsuo, Tatsuya Mikami, Yoshinori Tamada, Masahiko Tomiyama, Shingo Kakeda

Erschienen in: European Radiology | Ausgabe 8/2024

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Abstract

Objectives

Previous studies have shown possible choroid plexus (CP) dysfunction in Alzheimer’s disease (AD) and highlighted CP enlargement on magnetic resonance imaging (MRI) as a predictive factor of AD. However, few studies have assessed the relationship between CP volume (CPV) and mild cognitive impairment (MCI). In this large elderly population study, we investigated the changes in CPV in patients with MCI using MRI above 65 years.

Methods

This cross-sectional study included 2144 participants (median age, 69 years; 60.9% females) who underwent 3T MRI; they were grouped as 218 MCI participants and 1904 cognitively healthy controls. The total intracranial volume (ICV), total brain volume (TBV), CPV, hippocampal volume (HV), and lateral ventricle volume (LVV) were calculated.

Results

CPV/ICV was a significant independent predictor of MCI (p < 0.01) after adjusting for potential confounders (age, sex, hypertension, hyperlipidemia, diabetes, and education level). The CPV/ICV ratio was also a significant independent predictor of MCI after adjusting for the TBV/ICV ratio (p = 0.022) or HV/ICV ratio (p = 0.017), in addition to potential confounders. The CPV was significantly correlated with the LVV (r = 0.97, p < 0.01).

Conclusion

We identified a relationship between CPV and MCI, which could not be explained by the degree of brain atrophy. Our results support CP dysfunction in MCI.

Clinical relevance statement

Choroid plexus volume measurement may serve as a valuable imaging biomarker for diagnosing and monitoring mild cognitive impairment. The enlargement of the choroid plexus, independent of brain atrophy, suggests its potential role in mild cognitive impairment pathology.

Key Points

• The study examines choroid plexus volume in relation to cognitive decline in elderly.
• Enlarged choroid plexus volume independently indicates mild cognitive impairment presence.
• Choroid plexus volume could be a specific biomarker for early mild cognitive impairment diagnosis.
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Metadaten
Titel
Choroid plexus enlargement in mild cognitive impairment on MRI: a large cohort study
verfasst von
Yoshihito Umemura
Keita Watanabe
Sera Kasai
Satoru Ide
Yuka Ishimoto
Miho Sasaki
Haruka Nagaya
Soichiro Tatsuo
Tatsuya Mikami
Yoshinori Tamada
Masahiko Tomiyama
Shingo Kakeda
Publikationsdatum
15.01.2024
Verlag
Springer Berlin Heidelberg
Erschienen in
European Radiology / Ausgabe 8/2024
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-023-10572-9

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