Chromosomal polymorphisms are independently associated with multinucleated embryo formation
- 12.09.2017
- Embryo Biology
Erschienen in:
- Verfasst von
- Ling Sun
- Zhi-Heng Chen
- Li Yang
- Cui-Xing Yi
- Jun Liu
- Chun-Quan Ou
- Erschienen in
- Journal of Assisted Reproduction and Genetics | Ausgabe 1/2018
Abstract
Purpose
The purpose of this study is to explore the factors associated with embryo multinucleation, particularly focused on the influence of parental chromosomal polymorphisms in embryo multinucleation.
Methods
This is a retrospective case-control study involving 1260 infertile couples undergoing their first IVF/ICSI cycles. Couples were screened for abnormalities in their karyotype and were evaluated for blastomere persistence of multinucleation. Demographic characteristics, stimulation protocol, and pregnant outcomes were analyzed using logistic regression analysis.
Results
The level of basal FSH was lower in the multinucleated embryos group (5.37 vs 5.72 IU/L). The Multinucleated embryos group received less gonadotropins (1788.5 vs 1891.3 IU), and the level of LH on day of HCG triggering was lower (1.09 vs 1.30 IU/L). More oocytes were recovered in the multinucleated embryos group (11.51 vs 9.23). Chromosomal polymorphisms were seen in at least 1 out of 163 (12.9%) couples. Multivariate logistic regression analysis revealed that chromosomal polymorphisms were independently associated with an increase in the occurrence risk of multinucleated embryos (OR = 1.61, 95% CI, 1.06–2.44) in the first IVF/ICSI cycle. The miscarriage rate in the multinucleated embryos group was 10% higher than that of the control group.
Conclusions
Chromosomal polymorphisms were independently associated with multinucleation embryo formation. A higher LH level on the day of HCG triggering was associated with a decreased chance of multinucleation.
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- Titel
- Chromosomal polymorphisms are independently associated with multinucleated embryo formation
- Verfasst von
-
Ling Sun
Zhi-Heng Chen
Li Yang
Cui-Xing Yi
Jun Liu
Chun-Quan Ou
- Publikationsdatum
- 12.09.2017
- Verlag
- Springer US
- Erschienen in
-
Journal of Assisted Reproduction and Genetics / Ausgabe 1/2018
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330 - DOI
- https://doi.org/10.1007/s10815-017-1037-9
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