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01.12.2012 | Research | Ausgabe 1/2012 Open Access

World Journal of Surgical Oncology 1/2012

Chromosomal structural analysis in carcinoma of the gallbladder

Zeitschrift:
World Journal of Surgical Oncology > Ausgabe 1/2012
Autoren:
Ruhi Dixit, Prabhat Kumar, Ratnakar Tripathi, Somprakash Basu, Rajnikanth Mishra, VK Shukla
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1477-7819-10-198) contains supplementary material, which is available to authorized users.

Competing interest

The authors declare that they have no competing interests.

Authors' contributions

RD and PK wrote the article. RT, SB, RM and VKS contributed to the concept, study design, data analysis, interpretation of results and approved the final manuscript.

Abstract

Background

The etiopathogenesis of gallbladder cancer is still unknown. Both environmental and patient factors have been incriminated in its cause. That it is found in pockets of epidemiological distribution raises an issue of genetic changes associated with it. The aim of this study was to find out the chromosomal changes in gallbladder cancer.

Methods

Lymphocyte cell culture was carried out on blood of gallbladder cancer patients to determine chromosomal banding abnormalities. Native PAGE was also evaluated to analyze lactate dehydrogenase (LDH), superoxide dismutase (SOD) and catalase enzyme activity from the same blood of gallbladder cancer patients.

Results

Out of 30 gallbladder cancer patients, 4 male showed breakage on the long arm of chromosome 1 while only one male patient showed the translocation from the long arm of chromosome 4 to the long arm of chromosome 6 in a male patient.

Conclusion

The aberrations found in our study may suggest underlying genetic predisposition for the development of gallbladder cancer. They can act as a marker for gallbladder cancer, which needs further study.
Zusatzmaterial
Authors’ original file for figure 1
12957_2012_1136_MOESM1_ESM.pdf
Authors’ original file for figure 2
12957_2012_1136_MOESM2_ESM.pdf
Authors’ original file for figure 3
12957_2012_1136_MOESM3_ESM.pdf
Authors’ original file for figure 4
12957_2012_1136_MOESM4_ESM.tiff
Literatur
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