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15.11.2020 | Review

Chronic Kidney Disease—Mineral and Bone Disorders: Pathogenesis and Management

Zeitschrift:
Calcified Tissue International
Autoren:
Jorge B. Cannata-Andía, Beatriz Martín-Carro, Julia Martín-Vírgala, Javier Rodríguez-Carrio, José Joaquín Bande-Fernández, Cristina Alonso-Montes, Natalia Carrillo-López
Wichtige Hinweise
Jorge B. Cannata-Andía and Beatriz Martín-Carro have equal contribution as first authors.
Cristina Alonso-Montes and Natalia Carrillo-López have equal contribution as senior authors.
Jorge B. Cannata-Andía and Natalia Carrillo-López have equal contribution as corresponding authors.

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Abstract

The key players of the chronic kidney disease-mineral and bone disorders (CKD-MBD) are calcium, phosphate, PTH, FGF23, and the vitamin D hormonal system. The progressive reduction of kidney function greatly modifies the tightly interrelated mechanisms that control these parameters. As a result, important changes occur in the bone and mineral hormonal axis, leading to changes in bone turnover with relevant consequences in clinical outcomes, such as decrease in bone mass with increased bone fragility and bone fractures and increased vascular and valvular calcification, also with great impact in the cardiovascular outcomes. So far, the knowledge of the mineral and bone disorders in CKD and the increased variety of efficacious therapies should lead to a better prevention and management of CKD-MBD.

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