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Current Pulmonology Reports
Erschienen in: Current Pulmonology Reports 4/2018

02.10.2018 | Lung Transplant (R Bag, Section Editor)

Chronic Lung Allograft Dysfunction

verfasst von: William F. Parker, Remzi Bag

Erschienen in: Current Pulmonology Reports | Ausgabe 4/2018

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Abstract

Purpose of Review

Synthesize recent developments in the understanding of chronic lung allograft dysfunction (CLAD) epidemiology, pathophysiology, outcomes, and treatments with a focus on the classification of CLAD into restrictive allograft syndrome (RAS) and from bronchiolitis obliterans syndrome (BOS).

Recent Findings

Chronic lung allograft dysfunction (CLAD) remains the leading cause of long-term morbidity and mortality in lung transplant recipients. Despite the lack of progress on improving outcomes, significant progress has been made in better characterizing the disease’s clinical and pathologic diversity. Most significantly, the clinical diagnosis of restrictive allograft syndrome (RAS) has been recognized as pathophysiologically distinct from bronchiolitis obliterans syndrome (BOS). Azithromycin remains the only treatment proven effective for CLAD, and its use has a modest impact on survival.

Summary

Important steps towards better classification and understanding of the CLAD disease processes have been made; however, more research is needed to develop effective therapies for this devastating condition.
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Metadaten
Titel
Chronic Lung Allograft Dysfunction
verfasst von
William F. Parker
Remzi Bag
Publikationsdatum
02.10.2018
Verlag
Springer US
Erschienen in
Current Pulmonology Reports / Ausgabe 4/2018
Elektronische ISSN: 2199-2428
DOI
https://doi.org/10.1007/s13665-018-0208-1

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