Introduction
Objectives of the study
Materials and methods
Settings and data sources
The study cohort
Follow-up
Drug exposure: the adherence to medications
Data structure and statistical analysis
The hierarchical structure of data
The median odds ratios
Determinants of patient adherence
Results
The study cohort
Comorbidities (%) | Lazio | Tuscany |
---|---|---|
Hypertension | 48.32 | 40.00 |
Lipid metabolism disorders | 22.44 | 21.81 |
Conduction disorders and cardiac dysrhythmias | 17.80 | 16.61 |
Diabetes | 17.58 | 16.94 |
Heart failure | 8.43 | 21.04 |
Adherence to medications
Age group | β-blockers | ACEI/ARBs | Statins | Antiplatelet |
---|---|---|---|---|
Lazio | ||||
35–54 | 54.20 | 59.35 | 82.20 | 73.14 |
55–69 | 54.24 | 67.50 | 83.43 | 75.66 |
70–84 | 49.35 | 69.28 | 74.35 | 75.72 |
85+ | 38.06 | 56.15 | 54.02 | 67.54 |
Total | 51.09 | 65.44 | 77.41 | 74.43 |
Tuscany | ||||
35–54 | 52.96 | 53.28 | 82.79 | 79.90 |
55–69 | 51.85 | 64.39 | 83.72 | 81.34 |
70–84 | 45.48 | 65.93 | 75.03 | 79.16 |
85+ | 32.16 | 50.79 | 44.75 | 70.24 |
Total | 46.32 | 61.12 | 73.80 | 78.46 |
Determinants of adherence to polytherapy
Variation among healthcare providers
Levels of healthcare system | Lazio | Tuscany | ||||
---|---|---|---|---|---|---|
MOR | p value | 95% CI | MOR | p value | 95% CI | |
Local health unit | 1.23 | 0.035 | 1.13–1.42 | 1.26 | 0.020 | 1.16–1.46 |
Local health district | 1.12 | 0.018 | 1.08–1.20 | 1.12 | 0.089 | 1.06–1.26 |
General practitioner | 1.17 | 0.144 | 1.07–1.49 | 1.09 | 0.349 | 1.01–3.03 |
Levels of healthcare system | Lazio | Tuscany | ||||
---|---|---|---|---|---|---|
MOR | p value | 95% CI | MOR | p value | 95% CI | |
Hospital of discharge | 1.30 | 0.001 | 1.21–1.44 | 1.31 | 0.001 | 1.22–1.44 |
Local health unit | 1.09 | 0.154 | 1.03–1.26 | 1.11 | 0.181 | 1.04–1.35 |
Local health district | 1.08 | 0.111 | 1.04–1.20 | ≈ 1.00 | – | – |
General practitioner | 1.15 | 0.175 | 1.07–1.49 | ≈ 1.00 | – | – |