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Current Allergy and Asthma Reports
Erschienen in: Current Allergy and Asthma Reports 7/2020

01.07.2020 | Rhinosinusitis (J Mullol, Section Editor)

Chronic Rhinosinusitis and Allergy: Increased Allergen Sensitization Versus Real Allergic Rhinitis Multimorbidity: a Systematic Review

verfasst von: Pongsakorn Tantilipikorn, Mongkhon Sompornrattanaphan, Triphoom Suwanwech, Premyot Ngaotepprutaram

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 7/2020

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Abstract

Purpose of Review

The objective of this article is to provide a recent update of the association between allergic inflammation and chronic rhinosinusitis. The systematic approach of this review article critically evaluates the literature published over the past few years and summarizes the specific pathophysiologic pathway of chronic sinonasal inflammation that has been postulated.

Recent Findings

From a systematic search of the Ovid Medline and Embase, 11 studies were included in a qualitative analysis of the association between systemic allergy and chronic rhinosinusitis (CRS). Of the 11 studies, four showed an association, three were inconclusive, and four did not show any association. From the systematic search, 50 studies suggested four possible pathophysiologic pathways that may explain the association of allergic inflammation and CRS, namely, (1) staphylococcal enterotoxin, (2) the innate immunity pathway, (3) mast cell–associated inflammation, and (4) dysbiosis of microbiota.

Summary

The association of systematic allergy and CRS remains inconclusive. The recent advances in the study of the pathophysiologic pathway of CRS may lead to the possibility of a targeted treatment option for CRS.
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Metadaten
Titel
Chronic Rhinosinusitis and Allergy: Increased Allergen Sensitization Versus Real Allergic Rhinitis Multimorbidity: a Systematic Review
verfasst von
Pongsakorn Tantilipikorn
Mongkhon Sompornrattanaphan
Triphoom Suwanwech
Premyot Ngaotepprutaram
Publikationsdatum
01.07.2020
Verlag
Springer US
Erschienen in
Current Allergy and Asthma Reports / Ausgabe 7/2020
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-020-00913-9

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