Backgroud
Cyclodialysis involves separation of the meridional ciliary muscle from the scleral spur [
1], resulting in a communication channel between the anterior chamber and the suprachoroidal space [
2]. Cyclodialysis may be due to trauma or have an iatrogenic cause, and occurs in 1%–11% of patients who have suffered blunt ocular trauma, with a mean rate of 4% [
3]. It can also occur as a complication of anterior segment surgery. Any surgical procedure involving iris manipulation could cause iatrogenic cyclodialysis. In one of the largest case-series to date, 7/52 cases of cyclodialysis occurred after ocular surgery (phacoemulsification, trabeculectomy, or vitrectomy) [
4]. Direct communication between the anterior chamber (AC) and the ciliochoroidal space permits excessive drainage of the aqueous humor, resulting in chronic hypotony. Its clinical manifestations include visual loss, corneal edema, shallowing of the AC, refractive changes, cataract, choroidal effusion or detachment, retinal and choroidal folding, optic disk swelling, venous tortuosity, and maculopathy [
5].
When cyclodialysis is found, the cleft should be closed as quickly as possible. Several methods have been reported to close cyclodialysis, such as: medical treatment (steroids and atropine) [
6]; laser treatment [
7]; cryocoagulation [
8]; diathermy [
1]; direct cyclopexy [
9]; scleral buckling [
10]; and combined vitrectomy, cryotherapy, and gas tamponade [
11]. In recent years, internal tamponade with a capsular tension ring (CTR) [
2], implantation of an intraocular lens (IOL) into the sulcus [
12,
13], or a combination of CTR and IOL implantation [
14,
15] have been proposed to treat traumatic cyclodialysis, and these methods had satisfactory curative effects. Here, we present a case of cyclodialysis and chronic hypotony after trabeculectomy that was successfully treated by cataract surgery and insertion of a Cionni-modified capsular tension ring (MCTR) into the ciliary sulcus.
Discussion
The clinically common complications of persistent cyclodialysis are cataract, choroidal effusion, hypotonic maculopathy, and reduced vision [
13]. The vision loss is generally associated with hypotonic maculopathy [
16] and serious cataract. However, some studies have reported significant recovery in visual function many years after the onset of hypotony, and the longest reported interval was 30 years [
17]. It seems likely that visual acuity is mainly determined by the presence of concomitant pathologies (e.g. macular scars and retinal detachment) rather than the duration of hypotony or the extent of cyclodialysis [
18]. Therefore, to address the patient’s condition, it is better to close the cyclodialysis as soon as it is found.
To our knowledge, at least 20 different techniques have been proposed for treating cyclodialysis, including medical therapy, laser therapy, diathermy, cryocoagulation, surgery, and combinations of these methods. Ophthalmologists should choose the most appropriate treatment according to the patient’s clinical condition. Ormerod initially proposed an algorithm for the management of cyclodialysis in 1991 [
19]. Gonzalez-Martin-Moro et al. updated the treatment algorithm in 2016 [
4]. In the first step of treatment, they recommended conservative therapy with atropine and steroids. If ocular hypotonic maculopathy persisted for 2 months after stopping steroids, then invasive or semi-invasive methods should be performed. In the absence of concomitant pathology, the treatment selection should be guided by the size of the cleft. In eyes with a small cleft (< 3 clock hours), semi-invasive laser therapy should be performed. If medical treatment is ineffective in medium-sized clefts (3–6 clock hours), or if medical and laser treatment have failed in eyes with a small cleft, then direct cyclopexia should performed. In large clefts (> 6 clock hours), posterior segment surgery seems to be the safest option. In eyes with a concomitant pathology, treatment methods that simultaneously address both pathologies should be chosen (vitrectomy in eyes with retinal pathology and cataract surgery in eyes with significant cataract) [
4].
Our patient underwent trabeculectomy 3 months earlier that left a filter bleb above the corneal limbus. Direct cyclopexia was expected to do more harm than good in this case for several reasons. First, direct cyclopexia would necessitate opening the filter bleb to expose the suspected cyclodialysis cleft, destroying the filtration function of the bleb after surgery. Second, direct cyclopexia could cause severe intraoperative hypotony and other potential complications, such as intraocular hemorrhage, endophthalmitis, vitreous loss, retinal detachment, and wound dehiscence [
20]. Third, suturing a hypotonic eye is challenging, requiring careful and prolonged surgery. Finally, the time to recover from this procedure might be quite long.
Although internal tamponade using an MCTR and insertion of an IOL into the ciliary sulcus to close traumatic cyclodialysis was reported 10 years ago, this is the first time that this approach has been used to treat iatrogenic cyclodialysis, specifically in a patient after trabeculectomy, and we improved this method in our case. We rotated the MCTR to ensure the maximum focal point was aligned with the site of the most severe cyclodialysis after trabeculectomy for the greatest tamponade effect. Before we fixed the sutures, the surgeon pulled the sutures carefully to ensure the MCTR tamponade was not too tight or too loose in the ciliary sulcus. The tightness of the suture was determined based on the surgeon’s experience. The MCTR was sutured to the corneal limbus with one pass through the eyelet at 8:30 o’clock and another pass through the 2:00 o’clock position, so the angle between the two sutures was <180 °. The tamponade effect of the MCTR at its maximum focal point is stronger at this angle than at an angle of 180 °.
MCTRs with two eyelets can be sutured in place more stably than MCTRs with one eyelet, as used by Yuen et al. in 2006 [
2]. If the posterior chamber IOL is placed in the ciliary sulcus without suturing, as in prior reports [
12‐
14], the tamponade effect cannot be controlled by the surgeon, and this effect could be lost or attenuated if the IOL is rotated spontaneously or by postoperative factors. In 2016, Gupta et al. [
15] reported a case in which they fixed the sulcus using a Cionni ring, and a posterior chamber IOL was placed in the ciliary sulcus to close the cyclodialysis. Although this method increased the stability and tamponade effect of the MCTR, it increased the surgical difficulty and the risk of postoperative complications such as erosion, hemorrhage, and severe inflammation.
With recent improvements in surgical skills, as mentioned above, it seems that tamponade with an MCTR will be more effective in our case. In addition, we could treat the cataract and avoid secondary surgery. Compared with other methods already used to treat cyclodialysis, our method is potentially more effective, easier to perform, reduces operation time, causes less trauma, and shortens recovery time. The surgical method can be adjusted according to the patient’s specific condition. For example, in patients with zonular loss, the surgeon can insert another CTR in the capsular bag to stabilize the lens, as we have performed in an unreported case. This surgery can be used for traumatic and iatrogenic cyclodialysis, especially in patients with cyclodialysis and cataract.
Satisfactory closure of the cyclodialysis is not only dependent on the moderate internal compression elicited by the MCTR but is also on the severity of postoperative inflammation. Hypertony on postoperative day 1 is thought to be due to the recovery of aqueous humor production by the ciliary body and partial functional recovery of the trabecular meshwork [
14]. The IOP returns to normal after full functional recovery of the trabecular meshwork, permitting discontinuation of anti-glaucoma eye-drops. The recovery of the choroidal detachment on postoperative day 1 was due to hypertension and closure of the cyclodialysis cleft. Detachment of the ciliary body had completely recovered by 3 months after surgery in our case, and we think that the suprachoroidal effusion had a high protein concentration, and took some time to be completely absorbed.