01.12.2017 | Review | Ausgabe 1/2017 Open Access

Circular RNAs in cancer: an emerging key player
- Zeitschrift:
- Journal of Hematology & Oncology > Ausgabe 1/2017
Background
Biogenesis of circRNAs
Biological functions of circRNAs
miRNA sponge
Regulators of transcription
Translation of circRNAs into protein/peptide
Metabolism of circRNAs
CircRNAs in cancer
Cancer name
|
CircRNA name
|
Expression level
|
Scope
|
Sample
|
Intersection molecules and/or pathway
|
References
|
---|---|---|---|---|---|---|
Bladder carcinoma
|
circTCF25
|
Up
|
Bladder carcinoma vs normal
|
Tissues (
n = 40)
|
miR-103a-3p,miR-107; circTCF25-miR-103a-3p/miR-107-CDK6
|
Zhong et al. [
28]
|
cSCC
|
hsa_circ_0035381
|
Up
|
cSCC vs normal
|
Tissues (
n = 12)
|
hsa-miR-124-5p,hsa-miR-9-5p
|
Sand et al. [
32]
|
hsa_circ_0022383
|
Down
|
hsa-miR-124-5p
|
||||
ESCC
|
cir-ITCH
|
Down
|
ESCC vs normal
|
Tissues (
n = 684)
|
miR-7, miR-17, and miR-214;Wnt/β-catenin pathway
|
Li et al. [
34]
|
Gastric cancer
|
has_circ_002059
|
Down
|
Gastric cancer vs normal
|
Tissues (
n = 101)
|
–
|
Li et al. [
23]
|
Plasma (
n = 36)
|
||||||
CRC
|
hsa_circ_001988
|
Down
|
CRC vs normal
|
Tissues (
n = 31)
|
–
|
Wang et al. [
24]
|
cir-ITCH
|
Down
|
CRC vs normal
|
Tissues (
n = 45)
|
Wnt/β-catenin pathway
|
Huang et al. [
25]
|
|
HCC
|
hsa_circ_0001649
|
Down
|
HCC vs normal
|
Tissues (
n = 89)
|
–
|
Qin et al. [
26]
|
LSCC
|
hsa_circ_104912
|
Down
|
LSCC vs normal
|
Tissues (
n = 52)
|
–
|
Xuan et al. [
27]
|
hsa_circ_100855
|
Up
|
|||||
APL
|
f-circRNA
|
–
|
f-circRNA-expressing vas normal
|
Cells
|
PI3K and MAPK signal transduction pathways
|
Guarnerio et al. [
29]
|