nach oben

Journal of Cancer Research and Clinical Oncology

Erschienen in:

01.04.2012 | Original Paper

Circulating microRNA-218 was reduced in cervical cancer and correlated with tumor invasion

verfasst von: Jinjin Yu, Yuan Wang, Ruofan Dong, Xiaoyan Huang, Suning Ding, Haifeng Qiu

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 4/2012

Einloggen, um Zugang zu erhalten

Abstract

Backgrounds

microRNA-218 was proved to be a tumor-suppressor microRNA in several cancers, but its status in cervical cancer patients has not been established. In this study, we investigated the expression of microRNA-218 in the sera from cervical cancer patients and its relationships with clinico-pathological characteristics.

Methods

The expression of microRNA-218 was detected in the sera of 90 cervical cancer patients and 50 normal age-matched women by quantitative real-time PCR. The clinical data were collected and analyzed by statistical software.

Results

In the cancer group, microRNA-218 was reduced significantly in the sera (P < 0.001). Moreover, decreased microRNA-218 was associated with later stages, cervical adenocarcinoma, and lymphatic node metastasis.

Conclusions

microRNA-218 was deregulated in most cervical cancer patients and associated with tumor invasion.

Alajez NM, Lenarduzzi M, Ito E, Hui AB, Shi W, Bruce J, Yue S, Huang SH, Xu W, Waldron J, O’Sullivan B, Liu FF (2011) MiR-218 suppresses nasopharyngeal cancer progression through downregulation of survivin and the SLIT2-ROBO1 pathway. Cancer Res 71:2381–2391PubMedCrossRef

Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116:281–297PubMedCrossRef

Brase JC, Wuttig D, Kuner R, Sultmann H (2010) Serum microRNAs as non-invasive biomarkers for cancer. Mol Cancer 9:306PubMedCrossRef

Davis BN, Hata A (2010) microRNA in cancer—the involvement of aberrant microRNA biogenesis regulatory pathways. Genes Cancer 1:1100–1114CrossRef

Gao C, Zhang Z, Liu W, Xiao S, Gu W, Lu H (2009) Reduced microRNA-218 expression is associated with high nuclear factor kappa B activation in gastric cancer. Cancer 116:41–49

Gien LT, Beauchemin MC, Thomas G (2010) Adenocarcinoma: a unique cervical cancer. Gynecol Oncol 116:140–146PubMedCrossRef

Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011) Global cancer statistics. CA Cancer J Clin 61:69–90PubMedCrossRef

Kloosterman WP, Plasterk RH (2006) The diverse functions of microRNAs in animal development and disease. Dev Cell 11:441–450PubMedCrossRef

Kosaka N, Iguchi H, Ochiya T (2010) Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis. Cancer Sci 101:2087–2092PubMedCrossRef

Lee JW, Choi CH, Choi JJ, Park YA, Kim SJ, Hwang SY, Kim WY, Kim TJ, Lee JH, Kim BG, Bae DS (2008) Altered MicroRNA expression in cervical carcinomas. Clin Cancer Res 14:2535–2542PubMedCrossRef

Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, Sweet-Cordero A, Ebert BL, Mak RH, Ferrando AA, Downing JR, Jacks T, Horvitz HR, Golub TR (2005) MicroRNA expression profiles classify human cancers. Nature 435:834–838PubMedCrossRef

Small EM, Sutherland LB, Rajagopalan KN, Wang S, Olson EN (2010) MicroRNA-218 regulates vascular patterning by modulation of Slit-Robo signaling. Circ Res 107:1336–1344PubMedCrossRef

Song L, Huang Q, Chen K, Liu L, Lin C, Dai T, Yu C, Wu Z, Li J (2010) miR-218 inhibits the invasive ability of glioma cells by direct downregulation of IKK-beta. Biochem Biophys Res Commun 402:135–140PubMedCrossRef

STATBITE (2011) http://info.cancerresearchuk.org/cancerstats/types/cervix/survival/

Tatarano S, Chiyomaru T, Kawakami K, Enokida H, Yoshino H, Hidaka H, Yamasaki T, Kawahara K, Nishiyama K, Seki N, Nakagawa M (2011) miR-218 on the genomic loss region of chromosome 4p15.31 functions as a tumor suppressor in bladder cancer. Int J Oncol 39:13–21PubMed

Tie J, Pan Y, Zhao L, Wu K, Liu J, Sun S, Guo X, Wang B, Gang Y, Zhang Y, Li Q, Qiao T, Zhao Q, Nie Y, Fan D (2010) MiR-218 inhibits invasion and metastasis of gastric cancer by targeting the Robo1 receptor. PLoS Genet 6:e1000879PubMedCrossRef

Uesugi A, Kozaki K, Tsuruta T, Furuta M, Morita K, Imoto I, Omura K, Inazawa J (2011) The tumor suppressive microRNA miR-218 targets the mTOR component rictor and inhibits AKT phosphorylation in oral cancer. Cancer Res 71:5765–5778PubMedCrossRef

Wu DW, Cheng YW, Wang J, Chen CY, Lee H (2010) Paxillin predicts survival and relapse in non-small cell lung cancer by microRNA-218 targeting. Cancer Res 70:10392–10401PubMedCrossRef

Zhang B, Pan X, Cobb GP, Anderson TA (2007) microRNAs as oncogenes and tumor suppressors. Dev Biol 302:1–12PubMedCrossRef

Zhang Z, Li Z, Gao C, Chen P, Chen J, Liu W, Xiao S, Lu H (2008) miR-21 plays a pivotal role in gastric cancer pathogenesis and progression. Lab Invest 88:1358–1366PubMedCrossRef

Titel: Circulating microRNA-218 was reduced in cervical cancer and correlated with tumor invasion
verfasst von: Jinjin Yu
Yuan Wang
Ruofan Dong
Xiaoyan Huang
Suning Ding
Haifeng Qiu
Publikationsdatum: 01.04.2012
Verlag: Springer-Verlag
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 4/2012
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-012-1147-9

Neu im Fachgebiet Onkologie

24.04.2024 | DGIM 2024 | Nachrichten

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Circulating microRNA-218 was reduced in cervical cancer and correlated with tumor invasion

Abstract

Backgrounds

Methods

Results

Conclusions

Neu im Fachgebiet Onkologie

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Krebspatienten impfen: Was? Wen? Und wann nicht?

Müde im Alter? Auch an die Nebenniere denken

Update Onkologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Backgrounds

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 4/2012

Expression of tumor suppressor gene ING4 in ovarian carcinoma is correlated with microvessel density

Combination of a MDR1-targeted replicative adenovirus and chemotherapy for the therapy of pretreated ovarian cancer

The tumor suppressor role of Src homology phosphotyrosine phosphatase 2 in hepatocellular carcinoma

Efficacy and safety of vascular endothelial growth factor receptor tyrosine kinase inhibitors in patients with metastatic renal cell carcinoma and poor risk features

miR-181a sensitizes resistant leukaemia HL-60/Ara-C cells to Ara-C by inducing apoptosis

The functional MDM2 T309G genetic variant but not P53 Arg72Pro polymorphism is associated with risk of sarcomas: a meta-analysis

Neu im Fachgebiet Onkologie

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Krebspatienten impfen: Was? Wen? Und wann nicht?

Müde im Alter? Auch an die Nebenniere denken

Update Onkologie