Circulating miRNAs as potential biomarkers for light intensity exercise-induced enhancements in empathy
- 23.08.2023
- Research
- Verfasst von
- Takeru Shima
- Reika Kawabata-Iwakawa
- Hayate Onishi
- Tomonori Yoshikawa
- Keisuke Yoshii
- Yuika Yoshikawa
- Erschienen in
- Sport Sciences for Health | Ausgabe 2/2024
Abstract
Purpose
Exercise positively impacts social abilities like empathy, which is indispensable for sustaining relationships with others. Regular exercise at light intensity enhances empathic behavior; nonetheless, its biomarkers remain unknown. Here, we evaluated the effects of light-intensity exercise, which enhances helping behavior, on circulating miRNA profile in mice.
Methods
Eight-week-old male C57BL/6 mice were subjected to exercise at light intensity (7.0 m/min, 30 min/day, 5 days/week) for four weeks and a helping behavior test. The plasma was subsequently collected to analyze miRNA expressions using next-generation sequencing.
Results
We found that four weeks of light-intensity exercise significantly increased 11 miRNAs in the plasma of mice. This exercise regimen also significantly reduced 29 miRNAs in the plasma of mice. Seven out of 11 upregulated miRNAs and nine of 29 downregulated miRNAs showed significant correlations with helping behavior in mice; the miRNAs related to neuronal growth were also included, such as miR-29a-3p and miR-142b.
Conclusion
These results imply that miRNAs are applicable as liquid biomarkers for reflecting the effects of light-intensity exercise on empathy; it might also be developed as a possible indicator for treating empathy.
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- Titel
- Circulating miRNAs as potential biomarkers for light intensity exercise-induced enhancements in empathy
- Verfasst von
-
Takeru Shima
Reika Kawabata-Iwakawa
Hayate Onishi
Tomonori Yoshikawa
Keisuke Yoshii
Yuika Yoshikawa
- Publikationsdatum
- 23.08.2023
- Verlag
- Springer Milan
- Erschienen in
-
Sport Sciences for Health / Ausgabe 2/2024
Print ISSN: 1824-7490
Elektronische ISSN: 1825-1234 - DOI
- https://doi.org/10.1007/s11332-023-01111-6
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