nach oben

Archives of Gynecology and Obstetrics

Erschienen in:

11.10.2019 | Review

Circulating non-coding RNAs as non-invasive diagnostic markers of endometriosis: a comprehensive meta-analysis

verfasst von: Yanhui Li, Qionghua Chen

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 5/2019

Einloggen, um Zugang zu erhalten

Abstract

Background

Circulating non-coding RNAs have great potential for diagnosing endometriosis as non-invasive markers. We have assessed the potential accuracy and utility for diagnosis of endometriosis.

Methods

We searched many bases to identify the included literature, which included English bases, such as, Pubmed, Embase, Web of Science, Cochrane library and Chinese bases, for instance, CNKI, Wang Fang, VIP, DuXiu, ChaoXing. We also calculated the general sensitivity and specificity, negative likelihood ratio, positive likelihood ratio, diagnostic odds ratio, ROC curve plotting and so on with Stata 15. I² could test the heterogeneity of the meta-analysis, the funnel plot valuated whether meta-analysis had a publication bias. Regression analysis could explore heterogeneity in studies.

Result

Comprehensive reading and integrating extracted data, we included 11 published papers. The total number of people included in the case group was 453, and the control group was 362. We, respectively, calculated the general sensitivity and general specificity which were 0.81 (95% CI 0.76–0.85) and 0.77 (95% CI 0.71–0.82) by bivariate analysis. The area under the ROC curve was 0.86 (95% CI 0.83–0.89). There was significant heterogeneity in studies which is I² = 89.62% (95% CI 87.41%–91.83%). In addition, the results of meta-regression and subgroup analysis showed that the heterogeneity might come from gold standard, evaluation standard, experimental group size, experimental sample and race

Conclusion

The circulating non-coding RNAs have great ability of diagnosing endometriosis as non-invasive markers which were performed robustly and accurately.

Nur mit Berechtigung zugänglich

Nnoaham KE, Hummelshoj L, Webster P, d'Hooghe T, de Cicco Nardone F, de Cicco Nardone C, Jenkinson C, Kennedy SH, Zondervan KT, World Endometriosis Research Foundation Global Study of Women's Health c (2011) Impact of endometriosis on quality of life and work productivity: a multicenter study across ten countries. Fertil Steril 96(2):366 e368–373 e368. https://doi.org/10.1016/j.fertnstert.2011.05.090 CrossRef

Giudice LC, Kao LC (2004) Endometriosis. The Lancet 364(9447):1789–1799. https://doi.org/10.1016/s0140-6736(04)17403-5 CrossRef

Giudice LC (2010) Clinical practice Endometriosis. N Engl J Med 362(25):2389–2398. https://doi.org/10.1056/NEJMcp1000274 CrossRefPubMedPubMedCentral

Simoens S, Hummelshoj L, D'Hooghe T (2007) Endometriosis: cost estimates and methodological perspective. Hum Reprod Update 13(4):395–404. https://doi.org/10.1093/humupd/dmm010 CrossRefPubMed

Fourquet J, Gao X, Zavala D, Orengo JC, Abac S, Ruiz A, Laboy J, Flores I (2010) Patients' report on how endometriosis affects health, work, and daily life. Fertil Steril 93(7):2424–2428. https://doi.org/10.1016/j.fertnstert.2009.09.017 CrossRefPubMedPubMedCentral

Kennedy S, Bergqvist A, Chapron C, D'Hooghe T, Dunselman G, Greb R, Hummelshoj L, Prentice A, Saridogan E, Endometriosis ESIGf, Endometrium Guideline Development G (2005) ESHRE guideline for the diagnosis and treatment of endometriosis. Hum Reprod (Oxf Engl) 20(10):2698–2704. https://doi.org/10.1093/humrep/dei135 CrossRef

Yang JX, Rastetter RH, Wilhelm D (2016) Non-coding RNAs: an introduction. Adv Exp Med Biol 886:13–32. https://doi.org/10.1007/978-94-017-7417-8_2 CrossRefPubMed

Maracaja-Coutinho V, Paschoal AR, Caris-Maldonado JC, Borges PV, Ferreira AJ, Durham AM (2019) Noncoding RNAs databases: current status and trends. Methods Mol Biol 1912:251–285. https://doi.org/10.1007/978-1-4939-8982-9_10 CrossRefPubMed

Carthew RW, Sontheimer EJ (2009) Origins and mechanisms of miRNAs and siRNAs. Cell 136(4):642–655. https://doi.org/10.1016/j.cell.2009.01.035 CrossRefPubMedPubMedCentral

10.

Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL, Peterson A, Noteboom J, O'Briant KC, Allen A, Lin DW, Urban N, Drescher CW, Knudsen BS, Stirewalt DL, Gentleman R, Vessella RL, Nelson PS, Martin DB, Tewari M (2008) Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci USA 105(30):10513–10518. https://doi.org/10.1073/pnas.0804549105 CrossRefPubMedPubMedCentral

11.

Hawkins SM, Creighton CJ, Han DY, Zariff A, Anderson ML, Gunaratne PH, Matzuk MM (2011) Functional microRNA involved in endometriosis. Mol Endocrinol 25(5):821–832. https://doi.org/10.1210/me.2010-0371 CrossRefPubMedPubMedCentral

12.

May KE, Conduit-Hulbert SA, Villar J, Kirtley S, Kennedy SH, Becker CM (2010) Peripheral biomarkers of endometriosis: a systematic review. Hum Reprod Update 16(6):651–674. https://doi.org/10.1093/humupd/dmq009 CrossRefPubMedPubMedCentral

13.

Choi H, Koh HWL, Zhou L, Cheng H, Loh TP, Parvaresh Rizi E, Toh SA, Ronnett GV, Huang BE, Khoo CM (2019) Plasma protein and MicroRNA biomarkers of insulin resistance: a network-based integrative -omics analysis. Front Physiol 10:379. https://doi.org/10.3389/fphys.2019.00379 CrossRefPubMedPubMedCentral

14.

Carninci P, Sandelin A, Lenhard B, Katayama S, Shimokawa K, Ponjavic J, Semple CA, Taylor MS, Engstrom PG, Frith MC, Forrest AR, Alkema WB, Tan SL, Plessy C, Kodzius R, Ravasi T, Kasukawa T, Fukuda S, Kanamori-Katayama M, Kitazume Y, Kawaji H, Kai C, Nakamura M, Konno H, Nakano K, Mottagui-Tabar S, Arner P, Chesi A, Gustincich S, Persichetti F, Suzuki H, Grimmond SM, Wells CA, Orlando V, Wahlestedt C, Liu ET, Harbers M, Kawai J, Bajic VB, Hume DA, Hayashizaki Y (2006) Genome-wide analysis of mammalian promoter architecture and evolution. Nat Genet 38(6):626–635. https://doi.org/10.1038/ng1789 CrossRefPubMed

15.

Clark MB, Johnston RL, Inostroza-Ponta M, Fox AH, Fortini E, Moscato P, Dinger ME, Mattick JS (2012) Genome-wide analysis of long noncoding RNA stability. Genome Res 22(5):885–898. https://doi.org/10.1101/gr.131037.111 CrossRefPubMedPubMedCentral

16.

Wang KC, Chang HY (2011) Molecular mechanisms of long noncoding RNAs. Mol Cell 43(6):904–914. https://doi.org/10.1016/j.molcel.2011.08.018 CrossRefPubMedPubMedCentral

17.

Teng Y, Kang H, Chu Y (2019) Identification of an exosomal long noncoding RNA SOX2-OT in plasma as a promising biomarker for lung squamous cell carcinoma. Genetic Testing Mol Biomark 23(4):235–240. https://doi.org/10.1089/gtmb.2018.0103 CrossRef

18.

Zhang Y, Zhang L, Wang Y, Ding H, Xue S, Yu H, Hu L, Qi H, Wang Y, Zhu W, Liu D, Li P (2019) KCNQ1OT1, HIF1A-AS2 and APOA1-AS are promising novel biomarkers for diagnosis of coronary artery disease. Clin Exp Pharmacol Physiol. https://doi.org/10.1111/1440-1681.13094 CrossRefPubMedPubMedCentral

19.

Huang H, Zhu Z, Song Y (2019) Downregulation of lncrna uca1 as a diagnostic and prognostic biomarker for ovarian endometriosis. Rev Assoc Med Bras 65(3):336–341. https://doi.org/10.1590/1806-9282.65.3.336 CrossRefPubMed

20.

Lin D, Huang Q, Wu R, Dai S, Huang Z, Ren L, Huang S, Chen Q (2019) Long non-coding RNA AFAP1–AS1 promoting epithelial-mesenchymal transition of endometriosis is correlated with transcription factor ZEB1. Am J Reprod Immunol 81(1):e13074. https://doi.org/10.1111/aji.13074 CrossRefPubMed

21.

Zhang C, Wu W, Ye X, Ma R, Luo J, Zhu H, Chang X (2019) Aberrant expression of CHL1 gene and long non-coding RNA CHL1-AS1, CHL1-AS2 in ovarian endometriosis. Eur J Obstet Gynecol Reprod Biol 236:177–182. https://doi.org/10.1016/j.ejogrb.2019.03.020 CrossRefPubMed

22.

Nisenblat V, Bossuyt PM, Shaikh R, Farquhar C, Jordan V, Scheffers CS, Mol BW, Johnson N, Hull ML (2016) Blood biomarkers for the non-invasive diagnosis of endometriosis. Cochrane Database Syst Rev (5):Cd012179. https://doi.org/10.1002/14651858.cd012179

23.

Kiesel L, Sourouni M (2019) Diagnosis of endometriosis in the 21st century. Climacteric. https://doi.org/10.1080/13697137.2019.1578743 CrossRefPubMed

24.

Cho S, Mutlu L, Grechukhina O, Taylor HS (2015) Circulating microRNAs as potential biomarkers for endometriosis. Fertil Steril 103(5):1252–1260.e1251. https://doi.org/10.1016/j.fertnstert.2015.02.013 CrossRefPubMedPubMedCentral

25.

Cosar E, Mamillapalli R, Ersoy GS, Cho S, Seifer B, Taylor HS (2016) Serum microRNAs as diagnostic markers of endometriosis: a comprehensive array-based analysis. Fertil Steril 106(2):402–409. https://doi.org/10.1016/j.fertnstert.2016.04.013 CrossRefPubMed

26.

Jia SZ, Yang YP, Lang JH, Sun PR, Leng JH (2013) Plasma miR-17-5p, miR-20a and miR-22 are down-regulated in women with endometriosis. Hum Reprod 28(2):322–330. https://doi.org/10.1093/humrep/des413 CrossRefPubMed

27.

Maged AM, Deeb WS, El Amir A, Zaki SS, El Sawah H, Al Mohamady M, Metwally AA, Katta MA (2018) Diagnostic accuracy of serum miR-122 and miR-199a in women with endometriosis. Int J Gynecol Obstet 141(1):14–19. https://doi.org/10.1002/ijgo.12392 CrossRef

28.

Nisenblat V, Sharkey DJ, Wang Z, Evans SF, Healey M, Ohlsson Teague EMC, Print CG, Robertson SA, Hull ML (2019) Plasma miRNAs display limited potential as diagnostic tools for endometriosis. J Clin Endocrinol Metab 104(6):1999–2022. https://doi.org/10.1210/jc.2018-01464 CrossRefPubMed

29.

Pateisky P, Pils D, Szabo L, Kuessel L, Husslein H, Schmitz A, Wenzl R, Yotoya I (2018) hsa-miRNA-154-5p expression in plasma of endometriosis patients is a potential diagnostic marker for the disease. Reprod Biomed Online 37(4):449–466. https://doi.org/10.1016/j.rbmo.2018.05.007 CrossRefPubMed

30.

Rekker K, Saare M, Roost AM, Kaart T, Soritsa D, Karro H, Soritsa A, Simon C, Salumets A, Peters M (2015) Circulating miR-200-family micro-RNAs have altered plasma levels in patients with endometriosis and vary with blood collection time. Fertil Steril 104(4):938–946.e932. https://doi.org/10.1016/j.fertnstert.2015.06.029 CrossRefPubMed

31.

Suryawanshi S, Vlad AM, Lin HM, Mantia-Smaldone G, Laskey R, Lee M, Lin Y, Donnellan N, Klein-Patel M, Lee T et al (2013) Plasma microRNAs as novel biomarkers for endometriosis and endometriosis-associated ovarian cancer. Clin Cancer Res 19(5):1213–1224. https://doi.org/10.1158/1078-0432.CCR-12-2726 CrossRefPubMedPubMedCentral

32.

Wang WT, Sun YM, Huang W, He B, Zhao YN, Chen YQ (2016) Genome-wide Long non-coding RNA analysis identified circulating LncRNAs as novel non-invasive diagnostic biomarkers for gynecological disease. Sci Rep 6:23343. https://doi.org/10.1038/srep23343 CrossRefPubMedPubMedCentral

33.

Wang WT, Zhao YN, Han BW, Hong SJ, Chen YQ (2013) Circulating microRNAs identified in a genome-wide serum microRNA expression analysis as noninvasive biomarkers for endometriosis. J Clin Endocrinol Metab 98(1):281–289. https://doi.org/10.1210/jc.2012-2415 CrossRefPubMed

34.

Deeks JJ, Macaskill P, Irwig L (2005) The performance of tests of publication bias and other sample size effects in systematic reviews of diagnostic test accuracy was assessed. J Clin Epidemiol 58(9):882–893. https://doi.org/10.1016/j.jclinepi.2005.01.016 CrossRefPubMed

35.

Cui D, Ma J, Liu Y, Lin K, Jiang X, Qu Y, Lin J, Xu K (2018) Analysis of long non-coding RNA expression profiles using RNA sequencing in ovarian endometriosis. Gene 673:140–148. https://doi.org/10.1016/j.gene.2018.06.046 CrossRefPubMed

36.

Er TK, Su YF, Wu CC, Chen CC, Wang J, Hsieh TH, Herreros-Villanueva M, Chen WT, Chen YT, Liu TC, Chen HS, Tsai EM (2016) Targeted next-generation sequencing for molecular diagnosis of endometriosis-associated ovarian cancer. J Mol Med (Berl Ger) 94(7):835–847. https://doi.org/10.1007/s00109-016-1395-2 CrossRef

37.

Saare M, Rekker K, Laisk-Podar T, Soritsa D, Roost AM, Simm J, Velthut-Meikas A, Samuel K, Metsalu T, Karro H, Soritsa A, Salumets A, Peters M (2014) High-throughput sequencing approach uncovers the miRNome of peritoneal endometriotic lesions and adjacent healthy tissues. PLoS ONE 9(11):e112630. https://doi.org/10.1371/journal.pone.0112630 CrossRefPubMedPubMedCentral

38.

Liang Z, Chen Y, Zhao Y, Xu C, Zhang A, Zhang Q, Wang D, He J, Hua W, Duan P (2017) MiR-200c suppresses endometriosis by targeting MALAT1 in vitro and in vivo. Stem Cell Res Ther 8(1):251. https://doi.org/10.1186/s13287-017-0706-z

39.

Sahin C, Mamillapalli R, Yi KW, Taylor HS (2018) microRNA Let-7b: a novel treatment for endometriosis. J Cell Mol Med 22(11):5346–5353. https://doi.org/10.1111/jcmm.13807 CrossRefPubMedPubMedCentral

40.

Zhang C, Wu W, Zhu H, Yu X, Zhang Y, Ye X, Cheng H, Ma R, Cui H, Luo J, Guan J, Chang X (2018) Knockdown of long non-coding RNA CCDC144NL-AS1 attenuates migration and invasion phenotypes in endometrial stromal cells from endometriosis. Biol Reprod. https://doi.org/10.1093/biolre/ioy252 CrossRefPubMedPubMedCentral

41.

Zhang M, Wang S, Tang L, Wang X, Zhang T, Xia X, Fang X (2019) Downregulated circular RNA hsa_circ_0067301 regulates epithelial-mesenchymal transition in endometriosis via the miR-141/Notch signaling pathway. Biochem Biophys Res Commun. https://doi.org/10.1016/j.bbrc.2019.04.109 CrossRefPubMedPubMedCentral

42.

Agrawal S, Tapmeier TT, Rahmioglu N, Kirtley S, Zondervan KT, Becker CM (2018) The miRNA mirage: How close are we to finding a non-invasive diagnostic biomarker in endometriosis? a systematic review. Int J Mol Sci 19(2):599. https://doi.org/10.3390/ijms19020599 CrossRefPubMedCentral

43.

Bashti O, Noruzinia M, Garshasbi M, Abtahi M (2018) miR-31 and miR-145 as potential non-invasive regulatory biomarkers in patients with endometriosis. Cell J 20(1):84–89. https://doi.org/10.22074/cellj.2018.4915 CrossRefPubMedPubMedCentral

44.

Coutinho LM, Ferreira MC, Rocha ALL, Carneiro MM, Reis FM (2019) New biomarkers in endometriosis. Adv Clin Chem 89:59–77. https://doi.org/10.1016/bs.acc.2018.12.002 CrossRefPubMed

45.

Di Pietro C, Caruso S, Battaglia R, Iraci Sareri M, La Ferlita A, Strino F, Bonaventura G, Di Mauro M, Barcellona ML, Perciavalle V, Purrello M, Cianci A (2018) MiR-27a-3p and miR-124-3p, upregulated in endometrium and serum from women affected by Chronic Endometritis, are new potential molecular markers of endometrial receptivity. Am J Reprod Immunol (New York, NY: 1989) 80(3):e12858. doi: 10.1111/aji.12858.

46.

Haikalis ME, Wessels JM, Leyland NA, Agarwal SK, Foster WG (2018) MicroRNA expression pattern differs depending on endometriosis lesion type. Biol Reprod 98(5):623–633. https://doi.org/10.1093/biolre/ioy019 CrossRefPubMed

47.

Kopelman A, Girao MJ, Bonetti TC, Carvalho CV, da Silva ID, Schor E (2016) Analysis of gene expression in the endocervical epithelium of women with deep endometriosis. Reprod Sci (Thousand Oaks Calif) 23(9):1269–1274. https://doi.org/10.1177/1933719116638179 CrossRef

48.

Laudanski P, Charkiewicz R, Tolwinska A, Szamatowicz J, Charkiewicz A, Niklinski J (2015) Profiling of selected MicroRNAs in proliferative eutopic endometrium of women with ovarian endometriosis. Biomed Res Int 2015:760698. https://doi.org/10.1155/2015/760698 CrossRefPubMedPubMedCentral

49.

Tsai EM, Wang YS, Lin CS, Lin WY, Hsi E, Wu MT, Juo SH (2013) A microRNA-520 mirSNP at the MMP2 gene influences susceptibility to endometriosis in Chinese women. J Hum Genet 58(4):202–209. https://doi.org/10.1038/jhg.2013.1 CrossRefPubMed

50.

Vanhie A, El-Aalamat Y, O D, Peterse DP, Meuleman C, Fassbender A, D'Hooghe T (2016) A non-invasive test for endometriosis based on a panel of plasma microRNAs. Fertil Steril 106(3):e267 https://doi.org/10.1016/j.fertnstert.2016.07.770

51.

Anastasiadou E, Jacob LS, Slack FJ (2018) Non-coding RNA networks in cancer. Nat Rev Cancer 18(1):5–18. https://doi.org/10.1038/nrc.2017.99

Titel: Circulating non-coding RNAs as non-invasive diagnostic markers of endometriosis: a comprehensive meta-analysis
verfasst von: Yanhui Li
Qionghua Chen
Publikationsdatum: 11.10.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 5/2019
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-019-05290-x

Neu im Fachgebiet Gynäkologie und Geburtshilfe

23.04.2024 | Medikamente in Schwangerschaft und Stillzeit | Nachrichten

Update Gynäkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Circulating non-coding RNAs as non-invasive diagnostic markers of endometriosis: a comprehensive meta-analysis

Abstract

Background

Methods

Result

Conclusion

Neu im Fachgebiet Gynäkologie und Geburtshilfe

ICI-Therapie in der Schwangerschaft wird gut toleriert

Weniger postpartale Depressionen nach Esketamin-Einmalgabe

Bei RSV-Impfung vor 60. Lebensjahr über Off-Label-Gebrauch aufklären!

Harnwegsinfektprophylaxe: Es geht auch ohne Antibiotika

Update Gynäkologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Background

Methods

Result

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 5/2019

Bed rest after an embryo transfer: a systematic review and meta-analysis

When to do intracytoplasmic sperm injection: a prospective comparison

The expression of galectin-3 in breast cancer and its association with chemoresistance: a systematic review of the literature

Prognostic factors in Krukenberg tumor

Correction to: Laparoscopy versus open surgery for adnexal masses in pregnancy: a meta-analytic review

The propolis and boric acid can be highly suitable, alone/or as a combinatory approach on ovary ischemia-reperfusion injury

Neu im Fachgebiet Gynäkologie und Geburtshilfe

ICI-Therapie in der Schwangerschaft wird gut toleriert

Weniger postpartale Depressionen nach Esketamin-Einmalgabe

Bei RSV-Impfung vor 60. Lebensjahr über Off-Label-Gebrauch aufklären!

Harnwegsinfektprophylaxe: Es geht auch ohne Antibiotika

Update Gynäkologie