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Erschienen in:
05.05.2017 | Original Article
Circulating rotavirus genotypes in the Irish paediatric population prior to the introduction of the vaccination programme
Erschienen in: Irish Journal of Medical Science (1971 -) | Ausgabe 4/2017
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Background
Rotavirus is the leading cause of viral gastroenteritis in children, and it is anticipated that the introduction of the Rotarix™ vaccine (GlaxoSmithKline Biologicals S.A., Rixensart, Belgium) into the Irish immunisation schedule will result in a significant reduction of rotavirus-associated disease. In the pre- and post-vaccination eras, it is important to determine circulating strains of rotavirus to assess vaccine effectiveness, to monitor vaccine failures, and to detect potential emerging strains.
Aim
This study was a collaboration between the Temple Street Children’s University Hospital (TSCUH), Dublin, and the National Virus Reference Laboratory (NVRL), Dublin, to determine the then circulating rotavirus strains in a paediatric hospital.
Method
In the 2015/2016 period (July 2015–June 2016) 89 faecal samples from paediatric patients (53 from TSCUH, 36 from other hospitals) were characterised.
Results
The results showed G1P[8] to be the predominant genotype (57%), followed by G9P[8] (34%), G4P[8] (6%), G2P[4] (2%), and G12P[8] (1%).
Conclusion
This distribution of genotypes is comparable to those found in other European countries prior to vaccination suggesting that the vaccine should be highly efficacious in the Irish population.