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03.11.2018 | Observational Research

Circulating S100 proteins effectively discriminate SLE patients from healthy controls: a cross-sectional study

verfasst von: Barbora Šumová, Lucie Andrés Cerezo, Lenka Szczuková, Lucie Nekvindová, Michal Uher, Hana Hulejová, Radka Moravcová, Mariam Grigorian, Karel Pavelka, Jiří Vencovský, Ladislav Šenolt, Jakub Závada

Erschienen in: Rheumatology International | Ausgabe 3/2019

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Abstract

S100 proteins are currently being investigated as potential diagnostic and prognostic biomarkers of several cancers and inflammatory diseases. The aims of this study were to analyse the plasma levels of S100A4, S100A8/9 and S100A12 in patients with incomplete systemic lupus erythematosus (iSLE), in patients with established SLE and in healthy controls (HCs) and to investigate the potential utility of the S100 proteins as diagnostic or activity-specific biomarkers in SLE. Plasma levels were measured by ELISA in a cross-sectional cohort study of 44 patients with SLE, 8 patients with iSLE and 43 HCs. Disease activity was assessed using the SLEDAI-2K. The mean levels of all S100 proteins were significantly higher in SLE patients compared to HCs. In iSLE patients, the levels of S100A4 and S100A12 but not S100A8/9 were also significantly higher compared to HCs. There were no significant differences in S100 levels between the iSLE and SLE patients. Plasma S100 proteins levels effectively discriminated between SLE patients and HCs. The area under the curve (AUC) for S100A4, S100A8/9 and S100A12 plasma levels was 0.989 (95% CI 0.976–1.000), 0.678 (95% CI 0.563–0.792) and 0.807 (95% CI 0.715–0.899), respectively. S100 levels did not differentiate between patients with high and low disease activity. Only the S100A12 levels were significantly associated with SLEDAI-2K and with cSLEDAI-2K. S100 proteins were significantly higher in SLE patients compared HCs and particularly S100A4 could be proposed as a potential diagnostic biomarker for SLE.

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Titel: Circulating S100 proteins effectively discriminate SLE patients from healthy controls: a cross-sectional study
verfasst von: Barbora Šumová
Lucie Andrés Cerezo
Lenka Szczuková
Lucie Nekvindová
Michal Uher
Hana Hulejová
Radka Moravcová
Mariam Grigorian
Karel Pavelka
Jiří Vencovský
Ladislav Šenolt
Jakub Závada
Publikationsdatum: 03.11.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Rheumatology International / Ausgabe 3/2019
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-018-4190-2

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Circulating S100 proteins effectively discriminate SLE patients from healthy controls: a cross-sectional study

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