Circulating Tumor HPV DNA Kinetics for Squamous Cell Carcinoma of the Lacrimal Sac Treated with Chemoradiotherapy
- 01.12.2026
- Case Report
Erschienen in:
- Verfasst von
- Jonathan J. Paly
- William C. Faquin
- Ross D. Merkin
- Shriya Shukla
- Gjystina Lumaj
- Samuli Eldfors
- Qin Wang
- Dipon Das
- Daniel L. Faden
- Erschienen in
- Head and Neck Pathology | Ausgabe 1/2026
Abstract
Introduction
Lacrimal sac squamous cell carcinoma (LSSCC) is the most common tumor of the rare disease subsite of the nasolacrimal system. Circulating tumor DNA (ctDNA) has emerged as a biomarker for non-invasive monitoring of tumor burden and treatment response across a variety of solid tumors.
Methods
In this case study, we report on two patients with histologically confirmed HPV + (HPV16 and HPV33) LSSCC managed with definitive chemoradiotherapy who underwent serial ctDNA monitoring prior to, during, and following treatment using an ultrasensitive multi-feature HPV whole genome sequencing liquid biopsy.
Results
In this case study, we report on two patients with histologically confirmed HPV + (HPV16 and HPV33) LSSCC managed with definitive chemoradiotherapy who underwent serial ctDNA monitoring prior to, during, and following treatment using an ultrasensitive multi-feature HPV whole genome sequencing liquid biopsy.
Conclusions
This report suggests that ctDNA monitoring is a feasible approach for detection and monitoring of HPV + LSSCC. We advocate for continued p16 immunohistochemistry in all squamous cell carcinomas arising in the lacrimal sac. Confirmation with HPV ISH or PCR should be performed given the potential impact on management and surveillance.
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- Titel
- Circulating Tumor HPV DNA Kinetics for Squamous Cell Carcinoma of the Lacrimal Sac Treated with Chemoradiotherapy
- Verfasst von
-
Jonathan J. Paly
William C. Faquin
Ross D. Merkin
Shriya Shukla
Gjystina Lumaj
Samuli Eldfors
Qin Wang
Dipon Das
Daniel L. Faden
- Publikationsdatum
- 01.12.2026
- Verlag
- Springer US
- Erschienen in
-
Head and Neck Pathology / Ausgabe 1/2026
Elektronische ISSN: 1936-0568 - DOI
- https://doi.org/10.1007/s12105-026-01887-2
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