Clear Cell Odontogenic Carcinoma Harboring the EWSR1–ATF1 Fusion Gene: Report of a Rare Case
- 28.11.2019
- Case Reports
Erschienen in:
- Verfasst von
-
Thalita Santana
Thalita Santana
- Department of Oral and Maxillofacial Pathology, School of Dentistry, University of São Paulo–USP, 05508-000, São Paulo, Brazil
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Felipe Ledo de Andrade
Felipe Ledo de Andrade
- Department of Oral and Maxillofacial Surgery, Mandaqui Hospital Complex, São Paulo, Brazil
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Maria Carolina de Sousa Melo
Maria Carolina de Sousa Melo
- Department of Oral and Maxillofacial Surgery, Mandaqui Hospital Complex, São Paulo, Brazil
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Glauber Bareia Liberato da Rocha
Glauber Bareia Liberato da Rocha
- Dentistry Division, Clinics Hospital of the Medical School, University of São Paulo Paulo–USP, São Paulo, Brazil
-
Marília Trierveiler
Korrespondierender Autor Marília Trierveiler
- Department of Oral and Maxillofacial Pathology, School of Dentistry, University of São Paulo–USP, 05508-000, São Paulo, Brazil
- Erschienen in
- Head and Neck Pathology | Ausgabe 3/2020
Abstract
Clear cell odontogenic carcinoma (CCOC) is a rare and aggressive malignant epithelial neoplasm, which occurs most frequently in the mandible of elderly patients. Morphologically, CCOC shares similar characteristics with other clear cell tumors, especially hyalinizing clear cell carcinoma of the salivary glands (HCCC). Both CCOC and HCCC are known to harbor EWSR1 rearrangements, especially the EWSR1–ATF1 gene fusion, which indicates a possible link between the two lesions. So far, this fusion has been demonstrated in five cases of CCOC in the literature. Herein, we add another CCOC case to the literature, which arose in the mandible of an 82-year-old female patient and was proven to harbor the EWSR1–ATF1 gene fusion. Immunohistochemically, this case was focally positive for CK7, CK14, CK19 and p63. The patient was referred to surgical treatment; however, she died of disease 2 months after the diagnosis, thereby demonstrating the aggressive nature of this tumor.
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- Titel
- Clear Cell Odontogenic Carcinoma Harboring the EWSR1–ATF1 Fusion Gene: Report of a Rare Case
- Verfasst von
-
Thalita Santana
Felipe Ledo de Andrade
Maria Carolina de Sousa Melo
Glauber Bareia Liberato da Rocha
Marília Trierveiler
- Publikationsdatum
- 28.11.2019
- Verlag
- Springer US
- Erschienen in
-
Head and Neck Pathology / Ausgabe 3/2020
Elektronische ISSN: 1936-0568 - DOI
- https://doi.org/10.1007/s12105-019-01103-4
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