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20.10.2018 | Original Research | Ausgabe 4/2018 Open Access

Dermatology and Therapy 4/2018

Clinical and Genetic Risk Factors Associated with Psoriatic Arthritis among Patients with Psoriasis

Dermatology and Therapy > Ausgabe 4/2018
Di Yan, Richard Ahn, Stephen Leslie, Wilson Liao
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s13555-018-0266-x) contains supplementary material, which is available to authorized users.

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Psoriatic arthritis (PsA) is a chronic, inflammatory arthritis that affects an estimated 30% of patients with psoriasis [1]. Patients with PsA have a higher prevalence of cardio-metabolic comorbidities [2]. They are also at risk for permanent deformity and disability, decreased quality of life (QoL), reduced work productivity, increased risk of death, and higher healthcare utilization [3]. Currently, more than 50% of patients with PsA are untreated or undertreated with only topical medications [4]. Delays in PsA treatment, even as short as 6 months, can lead to decreased QoL, increased joint damage, and worse long-term physical function [5]. Early recognition of PsA is therefore crucial to reducing joint destruction and improving long-term disease outcomes.
While studies have found associations between PsA, smoking [68], obesity [9], genetic risk factors [10], and various psoriasis subtypes [11, 12], these studies looked at a limited set of variables and the results are sometimes contradictory or have yet to be confirmed by additional research. Furthermore, to our knowledge, no studies have developed models to predict the risk or presence if PsA.
The aim of this study was to assess the association of PsA with a multidimensional panel of clinical, demographic, environmental, and genetic factors and to develop clinically useful statistical models that help identify patients who are likely to have PsA.


Patient Population

Cross-sectional survey data were collected from 974 psoriasis patients seen at the University of California, San Francisco Department of Dermatology between 2006 and 2017. Subjects included both treatment-naïve patients and those on topical, systemic, and phototherapy treatments for psoriasis. Study subjects completed a detailed survey, providing information on demographic characteristics, personal and family medical history, smoking history, age of onset, history of previous and current psoriasis treatments, and clinical features (subtype, affected areas, severity [defined by percentage body surface area covered], aggravating factors, presence of joint symptoms) of psoriasis. The diagnosis of psoriasis was confirmed by a board-certified dermatologist who had examined the patient prior to enrollment. A confirmed diagnosis of PsA was defined as a diagnosis of PsA made by a rheumatologist or dermatologist with patient report of joint symptoms. Possible PsA was defined as the absence of an official diagnosis by a physician in the presence of current symptoms of joint swelling, pain, and stiffness in one or more joints. The absence of PsA was defined as a lack of clinical signs and symptoms as assessed by the physician, no patient-reported prior diagnosis of PsA by a physician, and no patient reported symptoms of possible PsA. For this study, only subjects with confirmed PsA were classified as having PsA and compared to subjects without PsA, while those with possible PsA were omitted from the analysis. This study was approved by the University of California, San Francisco’s institutional review board and informed consent was obtained from all subjects enrolled in the study.

Genetic Analysis

DNA was extracted from whole blood or saliva samples donated by the study participants using the Qiagen DNeasy kit (QIAGEN, Hilden, Germany) or the Oragene prepIT DNA extraction kit (DNA Genotek, Ottawa, ON, Canada), respectively. The DNA samples were genotyped using the Affymetix UK Biobank Array (Affymetix Inc., Santa Clara, CA, USA). The copy number of human leukocyte antigen (HLA)-C*06:02 and HLA-B*27 alleles were imputed from array data using HLA*IMP2, which has an accuracy of ≥ 95% for HLA-C and HLA-B [13].

Statistical Analyses

All statistical analyses were performed in R (version 3.3.2; R Foundation for Statistical Computing, Vienna, Austria). The initial pool of variables was selected based on evidence of possible associations with PsA in the literature and biological plausibility.

Association Models

To avoid over-fitting, the model was limited to one predictor for every ten events, with an event defined as the presence of PsA. Using this heuristic, we determined that our model could include a maximum of 17 predictor variables. For genetic variables we used a binary definition of positivity for the HLA-C*06:02 and HLA-B*27 alleles (patient did not have the HLA allele vs. the patient had at least one copy of the allele). Initial univariate analyses were conducted using Chi-squared tests or Fisher’s exact tests for categorical variables and two-tailed t tests for continuous variables. An a priori threshold of a p value of < 0.25 was used to select variables for inclusion in the subsequent multivariable logistic regression model. Demographic characteristics (age, age of onset, gender, body mass index [BMI]) were forced into the model to control for potential confounders. A backward elimination method based on the p value of the Wald test statistic was used to reduce the model to 17 predictor variables. Sensitivity analyses were conducted using alternative pre-defined p value thresholds of 0.15 and 0.05 to determine whether a more stringent barrier to inclusion would alter the results. We also used an alternative definition of severity as a four-level ordinal variable.

Prediction Models

We constructed two multivariable logistic regression models to predict the presence of PsA. Model 1 included only factors that are known to predate the onset of PsA, such as age of psoriasis onset, gender, family history of psoriasis, and the copy number of HLA-C*06:02 and HLA-B27 alleles. The full data set was used to assess the diagnostic ability of model 1 and construct a receiver operating characteristic curve.
For model 2, which included variables that were associated with PsA and not necessarily predating PsA onset, the dataset was split into a training set (25%) and independent test set used for validation (75%). The training set was used to develop model 2, while the test set was used to determine the internal validity of the model and construct the ROC curves. Stepwise regression based on the Akaike information criterion was used to build model 2 from a pool of all investigated variables. The variable, HLA-C*06:02 positivity, was forced into model 2 as previous studies had suggested that this allele has a significant protective effect against the development of PsA [1416]. The concordance statistic (c-index), defined as the area under the ROC curve was used to assess the predictive accuracy of the two predictive logistic regression models.
The presence of multicollinearity was assessed using the variance inflation factor. The generalized additive models approach was used to test the assumption that the continuous variables (age and age of onset) were linearly related to the logit in the logistic regression model [17]. The Hosmer–Lemeshow test was used to assess the models’ goodness of fit.


Description of Study Population

The prevalence of confirmed PsA in our cohort was 18.0% (n = 175), while the prevalence of subjects without confirmed PsA was 51% (n = 497). The average age of our study population was 44.6 years; 55% of our cohort was male and 44.9% were female. The average BMI was 27.1 kg/m2, a value which is considered to indicate clinically overweight and slightly above the national average [18]. Our study population drew from the Bay area of California and was predominantly Caucasian, Asian, and Hispanic/Latino. Characteristics of the training and internal validation cohorts are provided in Electronic Supplementary Material (ESM) Table S1.

Univariate Associations with PsA

We first analyzed a number of demographic, clinical, and genetic variables on a univariate basis for association with PsA (Table 1). We found significant positive associations for age (p = 0.024), scalp psoriasis (p = 0.004), elbow/knee psoriasis (p = 0.040), nail involvement (p = 8.2 × 10−08), skin fold involvement (p = 0.005), plaque subtype (p = 0.01), erythrodermic subtype (p = 0.014), severe psoriasis (p = 2.39 × 10−5), hypertension (p = 0.003), type 2 diabetes (p = 0.024), and coronary artery disease (p = 0.045). We found a significant negative association for the HLA-C*06:02 allele (p = 0.003).
Table 1
Univariate analysis of demographic, clinical, and genetics features associated with psoriatic arthritis
Demographic, clinical, and genetics features
Patient group
p valuea
OR [95% CI]b
No PsA
Mean age (years)
0.002 [0.0003–0.004]
Age of psoriasis onset (years)
− 0.001 [− 0.003 to 0.0006]
Gender, n female/total (% female)
85/175 (48.6%)
208/495 (42.0%)
1.30 [0.92–1.84]
0.006 [− 0.001 to 0.014]
Family history of psoriasis, n yes/total
(% yes)
98/175 (56.0%)
254/488 (52.0%)
1.17 [0.83–1.66]
HLA-C*06:02 positivity
38/175 (21.7%)
156/497 (31.4%)
0.53 [0.35–0.80]
HLA-B*27 positivity
11/175 (6.3%)
28/497 (5.6%)
1.05 [0.51–2.16]
Smoking, n yes/total (% yes)
6/175 (3.4%)
30/472 (6.4%)
0.52 [0.21–1.28]
Clinical factors
 Scalp involvement
153/175 (87.4%)
382/497 (76.9%)
2.09 [1.28–3.43]
 Ear involvement
114/175 (65.1%)
283/497 (56.9%)
1.40 [0.98–2.01]
 Elbow/knee involvement
145/175 (82.9%)
371/497 (74.6%)
1.62 [1.04–2.53]
 Arm/leg involvement
152/175 (86.9%)
423/497 (85.1%)
1.16 [0.70–1.91]
 Trunk involvement
133/175 (76.0%)
346/497 (69.6%)
1.38 [0.93–2.05]
 Face involvement
79/175 (45.1%)
206/497 (41.4%)
1.16 [0.82–1.64]
 Genital involvement
63/175 (36.0%)
142/497 (28.6%)
1.41 [0.98–2.03]
 Nail involvement
101/175 (57.7%)
170/497 (34.2%)
8.21 × 10−08***
2.63 [1.85–3.74]
 Palm involvement
40/175 (22.9%)
103/497 (20.7%)
1.13 [0.75–1.71]
 Sole involvement
39/175 (22.3%)
83/497 (16.7%)
1.43 [0.93–2.19]
 Skin fold involvement
79/175 (45.1%)
162/497 (32.6%)
1.69 [1.19–2.40]
 Gluteal cleft involvement
27/175 (15.4%)
84/497 (16.9%)
0.90 [0.56–1.44]
 Plaque subtype
157/175 (89.7%)
402/497 (80.9%)
2.06 [1.21–3.52]
 Guttate subtype
52/175 (29.7%)
137/497 (27.6%)
1.11 [0.76–1.62]
 Pustular subtype
11/175 (6.3%)
14/497 (2.8%)
2.31 [0.93–5.60]
 Erythrodermic subtype
13/175 (7.4%)
14/497 (2.8%)
2.77 [1.27–6.01]
 Palmoplantar subtype
13/175 (7.4%)
22/497 (4.4%)
1.73 [0.85–3.52]
 Inverse subtype
17/175 (9.7%)
29/497 (5.8%)
1.74 [0.93–3.24]
6/169 (3.6%)
30/497 (6.0%)
0.55 [0.23–1.35]
23/175 (13.1%)
107/497 (21.5%)
0.55 [0.34–0.90]
54/175 (30.9%)
185/497 (37.2%)
0.75 [0.52–1.09]
88/175 (50.3%)
159/497 (32.0%)
2.39 × 10−5***
2.15 [1.51–3.05]
61/175 (34.9%)
115/497 (23.1%)
1.78 [1.22–2.58]
 Diabetes, type 2
18/175 (10.3%)
25/497 (5.0%)
2.16 [1.15–4.07]
38/175 (21.7%)
119/497 (23.9%)
0.88 [0.58–1.33]
16/175 (9.1%)
31/497 (6.2%)
1.51 [0.81–2.84]
 Coronary artery disease
12/175 (6.8%)
15/497 (3.0%)
2.37 [1.08–5.16]
4/175 (2.3%)
7/497 (1.4%)
1.64 [0.35–6.53]
Values for variables are presented as the number of patients out of the total number of patients in that group, with the percentage of these patients given in parenthesis, with the exception of mean age and age of psoriasis onset
PsA Psoriatic arthritis, OR odds ratio, CI confidence interval, BMI body mass index, HLA human leukocyte antigen
*, **, ***Results are statistically significant at *p < 0.05 , **p value < 0.01, or highly significant at ***p < 0.001
ap values derived from t-tests or Wilcoxon rank sum tests for continuous variables and Chi squared or Fisher’s exact tests for categorical variables
bORs for continuous variables (age, age of onset, BMI) are per unit increase
cP value for severity included in model as severe or not severe (binary)
dVariables with p > 0.25
eIndicates a trend towards statistical significance (p value < 0.1)

Multivariate Association Model

Next, we built a multivariate association model using a backward elimination method (Table 2). Among the demographic characteristics included in the final multivariable logistic regression model, only the age of psoriasis onset showed a trend towards a higher odds of having PsA (p = 0.050). For every 1 year increase in the age of onset, the odds of having PsA decreased by 3%.
Table 2
Multivariable logistic regression model of psoriatic arthritis
Odds ratio [95% CI]b
p value
0.05 [0.00–0.53]
Nail involvement
3.01 [1.39–6.66]
HLA-C*06:02 positivity
0.33 [0.13–0.77]
Diabetes, type 2
5.27 [1.21–24.5]
Pustular subtype
6.11 [1.17–36.8]
Age of psoriasis onset
0.97 [0.94–1.00]
0.29 [0.06–1.01]
Skin fold involvement
2.09 [0.91–4.89]
1.03 [1.00–1.06]
Severe psoriasis
1.92 [0.88–4.21]
Soles involvement
0.44 [0.15–1.15]
Plaque subtype
2.63 [0.86–9.57]
Ears involvement
0.54 [0.22–1.29]
Elbows/knees involvement
1.88 [0.73–5.24]
0.53 [0.18–1.44]
Inverse subtype
2.08 [0.51–8.20]
1.22 [0.54–2.77]
0.99 [0.93–1.05]
A backward stepwise elimination procedure was used with a threshold of p < 0.25 for inclusion of variables in the initial model
*, **Results are statistically significant at *p < 0.05 or **p value < 0.01
aVariables listed in order of p value
bORs for continuous variables (age, age of onset, BMI) are per unit increase
cp value indicates a trend towards statistical significance (p < 0.1)
Clinical features, such as lesion location and psoriasis subtype, were also associated with increased odds of PsA. Patients who had nail psoriasis had a 3.01-fold higher odds of having PsA (95% confidence interval [CI] 1.39–6.66; p = 0.006) than did individuals without nail involvement. Those with pustular psoriasis had a 6.11-fold odds of having PsA (95% CI 1.40–36.41; p = 0.022) than did those who did not.
In terms of co-morbidities, subjects who had type 2 diabetes had a significant 5.27-fold increase in the odds of having PsA (95% CI 1.17–36.8; p = 0.037) that was independent of current BMI and hypertension status.
Genetically, individuals who were positive (heterozygous or homozygous) for the HLA-C*06:02 allele had a 67% reduction in the odds of having PsA relative to patients who lacked HLA- C*06:02. There was no significant difference in the odds of PsA for patients who had the HLA-B*27 allele.
A number of other variables showed a trend toward association with PsA in the multivariate model, but these were not statistically significant. These included intertriginous psoriasis, plaque psoriasis, severe psoriasis, and smoking (Table 2).

Sensitivity Analysis

Reducing the p value for entry into the model to 0.15 or 0.05 did not significantly change the parameter estimates or p values. The only variable appreciably affected was pustular psoriasis status, which had a p value of 0.064 in the univariate analyses and therefore did not make the cutoff for inclusion in the model that used an entry criteria of p < 0.05. The results of these sensitivity analyses (ESM Tables S2, S3, S4) suggest that our association model is fairly robust. Moreover, we conducted an additional sensitivity analysis examining whether forcing the variable of ethnicity/race (Caucasian, Asian, and Hispanic/Latino, Other) into the models altered the results and found that the none of our findings was significantly altered (ESM Appendix).

Multivariate Predictive Models

The association model assessed the relationship between PsA and the most significant factors found on univariate analysis while controlling for demographic variables; in comparison, the predictive models evaluated how well a set of variables predict the presence of PsA. The results of the multivariable logistic regression model using only factors that are known to predate PsA onset (model 1) are shown in Table 3. Only the HLA-C*06:02 allele was found to be a statistically significant predictor of PsA status (p = 0.001). Patients with one or more copies of the HLA-C*06:02 allele had a 55% reduction in the odds of having PsA compared to individuals who did not have any copies of the HLA-C*06:02 allele. The c-index was 0.615 (Fig. 1, suggesting that this limited model was only slightly better than random prediction (c-index of 0.500).
Table 3
Results of a predictive multivariable logistic regression model for presence of psoriatic arthritis that includes only factors predating the onset of psoriatic arthritis (model 1)
Odds ratio (95% CI)a
p value
0.55 [0.32–0.92]
Age of psoriasis onset
0.99 [0.98–1.00]
1.24 [0.83–1.84]
HLA-C*06:02 positivity
0.45 [0.29–0.70]
HLA-B*27 positivity
0.96 [0.43–1.99]
Family history of psoriasis
1.24 [0.83–1.87]
*, **, ***Results are statistically significant at *p < 0.05, **p value < 0.01, or highly significant at ***p < 0.001
aORs for continuous variables (age, age of onset, BMI) are per unit increase
bOdds ratio for females relative to the reference group of males
cIndicates a trend towards statistical significance (p < 0.1)
The results of model 2, derived from stepwise regression and using independent training and validation datasets are shown in Table 4. The c-index for model 2 in the training and test sets were 0.820 and 0.874, respectively (Fig. 2), which are significantly higher than that for model 1. Age of psoriasis onset, nail involvement, type 2 diabetes, and hypertriglyceridemia were all significant predictors of PsA in the derivation cohort. The Hosmer–Lemeshow test was not significant for any of the logistic regression models (model 2: p = 0.978), suggesting that the predicted and observed values were well calibrated with one another.
Table 4
Results of model 2, a multivariable logistic regression model for presence of psoriatic arthritis developed by stepwise regression from an initial pool of all demographic, clinical, environmental, and genetic factors
Odds ratio (95% CI)
p value
Model intercept
0.11 [0.01–0.87]
Demographic characteristics
 Age of psoriasis onset
0.96 [0.92–0.99]
2.56 [0.93–7.40]
Heritable factors
 HLA-C*06:02 positivity
0.60 [0.20–1.64]
Lesion location
 Ear involvement
0.35 [0.10–1.06]
 Nail involvement
3.92 [1.5–10.8]
 Cardiovascular disease
15.48 [0.84–610]
 Diabetes, type 2
9.91 [1.35–82.4]
0.03 [0.00–0.48]
 Plaque subtype
4.25 [0.94–26.4]
 Inverse subtype
5.26 [1.01–23.0]
 Pustular subtype
4.77 [0.57–47.4]
 Severe psoriasis
2.03 [0.77–5.44]
*, **Results are statistically significant at *p < 0.05 or **p value < 0.01
aOR for females relative to the reference group of males
bIndicates a trend towards statistical significance (p < 0.1)


Our multifactorial analysis of demographic, clinical, environmental, and genetic risk factors of PsA revealed new characteristics associated with PsA and demonstrate a novel predictive model that can help distinguish between those who have PsA and those who do not. For example, in one previous study the HLA-C*06:02 allele was associated with a tenfold increase in the risk of developing psoriasis [19], but the results of other studies suggest that the HLA-C*06:02 allele may be protective against the development of PsA. More specifically, in a cohort of 480 patients with PsA, Ho and colleagues showed that those with both the HLA-C*06:02 and HLA-DRB1*07 alleles had significantly fewer damaged and involved joints than PsA patients who did not carry either allele [10]. Furthermore, Winchester and colleagues found that the frequency of the HLA-C*06:02 allele was lower in patients with psoriatic arthritis than in patients with only cutaneous psoriasis. In particular, Haroon and colleagues found that the HLA-C*06:02 allele was negatively associated with asymmetrical sacroiliitis. In our psoriasis cohort, which included patients with and without PsA, we found that positivity for the HLA-C*06:02 allele was negatively associated with PsA, although it should be noted that the frequency of the HLA-C*06:02 allele in both patients with PsA (21.7%) and those with only psoriasis (31.4%) was still higher than that in the general population.
Our study also identifies a new heightened association of cardio-metabolic disease with PsA as compared to psoriasis without PsA. In the univariate association analysis, the presence of hypertension, coronary artery disease, or type 2 diabetes was significantly associated with risk of PsA among those with psoriasis. Moreover, type 2 diabetes was strongly associated with PsA and was a significant predictor of PsA status in model 2. These results are consistent with a previous study by Coto-Segura and colleagues who have shown that PsA increases the risk of type 2 diabetes by 2.1 fold [20]. Interestingly, these authors found that the treatment of diabetes with glucagon-like peptide 1 (GLP-1) analogues improved psoriasis symptoms in patients with both diabetes and psoriasis. Moreover, the authors of a prospective study conducted in the UK for 4 years involving 8124 adults with psoriasis and 76,599 adults without psoriasis found that psoriasis was a risk factor for incident diabetes [21]. Taken together, these results suggest a possible mechanistic link between PsA endocrine derangements in diabetes. While our study did not find a link between PsA and BMI or obesity, our survey data only included current BMI values and not the BMI values at age 18 years that Arabshahi-Soltani and colleagues [9] found to be associated with PsA. It is possible that only childhood obesity and not obesity in later life is associated with PsA. In fact, PsA seems to be positively associated with a younger age of onset in our cohort as well as in other studies [9, 22], suggesting that the clinical course in a patient’s childhood may set the stage for PsA in later life. Interestingly, hypertriglyceridemia was negatively associated with PsA in predictive model 2. High triglyceride levels may be a marker of treatment with systemic medications, such as retinoids [23], methotrexate [24], and tumor necrosis factor-alpha inhibitors [2527]; these medications have been associated with increased triglyceride levels and may be used to treat or delay the onset of PsA.
Certain clinical features also seem to be important predictors of PsA status. For example, nail psoriasis is seen in both our study and those of others [9, 12] to be associated with PsA. “Localized” pustular psoriasis has also been associated with PsA in a Korean psoriasis cohort studied by Choi and colleagues, although their study methods did not specify details on the covariates used [22]. Our models demonstrate an association between pustular psoriasis and PsA. The association between PsA and a more extensive form of pustular psoriasis is supported by the study of David and colleagues who described four cases of generalized pustular psoriasis occurring with systemic amyloidosis, PsA, and nephrotic syndrome [28]. Overall, more severe and extensive psoriasis has been positively linked to PsA [9, 12, 22] and is a significant predictor of PsA in model 2.
Some results of our study do differ from those reported in the literature. For example, while Wilson et al. described an association between PsA and inverse psoriasis [12], this was not seen in our cohort. However, involvement of the skin folds did trend towards a higher odds of having PsA. It is possible that the rarity of inverse psoriasis in our cohort (7.8% overall; 9.7% in PsA-positive subjects and 5.8% in PsA-negative subjects) may have limited our power to identify associations with PsA status. Wilson et al. [12] also reported a link between scalp psoriasis and PsA [12]. In our study, scalp psoriasis was significantly different in the univariate Chi-squared analysis, but it was not significantly associated with PsA in the multivariate logistic regression analysis nor was it a significant predictor of PsA status in model 2. This discrepancy may be due, in part, to differences in the statistical models used. Also, while the multivariable Cox proportional hazards models used by Wilson et al. [12] adjusted only for age, sex, and calendar year, the logistic regression models used in our study controlled for numerous other clinical and genetic factors. Thus, it is possible that there was no significant association between our models because they controlled for additional confounders that may have driven the relationship between scalp psoriasis and PsA in the analysis performed by Wilson et al. [12].
It is important to note that our study is limited by the retrospective and cross-sectional nature of our data, which prevented us from distinguishing the directionality of the relationship between PsA and the risk factors explored in our models. Furthermore, the cross-sectional data also prevented us from estimating the future risk of PsA, although our models can be used to help clinicians in stratifying patients who are more likely to have PsA and those who are not. Finally, the lack of precise characterization of joint involvement hampered full interpretation of study.


In this study we evaluated the association of PsA with a wide variety of risk factors and developed predictive models that can help clinicians make earlier diagnoses of PsA and prevent the debilitating long-term sequelae of the disease. These models demonstrate the predictive value of HLA alleles in combination with clinical and demographic factors to identify “high suspicion” patients who may be candidates for additional work-up. Further prospective studies are needed to understand how these risk factors contribute to the development of PsA and whether they can be used to predict future disease onset.



This study was supported in part by grants to Wilson Liao (NIH R01AR065174, NIH U01AI119125) and Di Yan (National Psoriasis Foundation Fellowship). No funding was received for article processing charges.


All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.


Di Yan, Richard Ahn, Stephen Leslie, and Wilson Liao have nothing to disclose.

Compliance with Ethics Guidelines

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.

Data Availability

The datasets during and/or analyzed during the current study are available from the corresponding author on reasonable request.

Open Access

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://​creativecommons.​org/​licenses/​by-nc/​4.​0/​), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Supplementary material 1 (DOCX 21 kb)
Supplementary material 2 (DOCX 22 kb)
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