The purpose of this study was to investigate the incidence, clinical presentation, and prognosis of Actinotignum bacteremia in southern Sweden. Actinotignum isolates in blood cultures were identified retrospectively between 1st January 2012 and 31st March 2016 through searches in the clinical microbiology laboratory database. The population covered by this laboratory is approximately 1.3 million. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) was used for species determination. Etests were used for minimum inhibitory concentration (MIC) determination. The patients’ medical charts were reviewed. Fifty-eight episodes in fifty-seven patients with Actinotignum bacteremia were identified (A. schaalii = 53, A. sanguinis = 1, A. urinale = 2, and Actinotignum species = 3), which corresponds to an incidence of 11 cases per million inhabitants. Fifty-one percent of the isolates were in pure culture. The MICs were low for β-lactam antibiotics, whereas high MICs were recorded for ciprofloxacin and trimethoprim. Patients had a median age of 82 years, 72% were male, and a majority had underlying urological conditions. Thirty-six of the patients were diagnosed with a focus from the urinary tract. Thirty-one patients developed severe sepsis and nine patients died during the hospital stay. Our study is the largest of Actinotignum bacteremia and demonstrates that it is a condition with a significant fatality that affects elderly persons with underlying conditions. β-Lactams represent a rational treatment option.
Lawson PA, Falsen E, Akervall E, Vandamme P, Collins MD (1997) Characterization of some Actinomyces-like isolates from human clinical specimens: reclassification of Actinomyces suis (Soltys and Spratling) as Actinobaculum suis comb. nov. and description of Actinobaculum schaalii sp. nov. Int J Syst Bacteriol 47(3):899–903 CrossRefPubMed
Yassin AF, Spröer C, Pukall R, Sylvester M, Siering C, Schumann P (2015) Dissection of the genus Actinobaculum: Reclassification of Actinobaculum schaalii Lawson et al. 1997 and Actinobaculum urinale Hall et al. 2003 as Actinotignum schaalii gen. nov., comb. nov. and Actinotignum urinale comb. nov., description of Actinotignum sanguinis sp. nov. and emended descriptions of the genus Actinobaculum and Actinobaculum suis; and re-examination of the culture deposited as Actinobaculum massiliense CCUG 47753T (= DSM 19118T), revealing that it does not represent a strain of this species. Int J Syst Evol Microbiol 65(Pt 2):615–624 CrossRefPubMed
Bank S, Søby KM, Kristensen LH, Voldstedlund M, Prag J (2015) A validation of the Danish microbiology database (MiBa) and incidence rate of Actinotignum schaalii ( Actinobaculum schaalii) bacteraemia in Denmark. Clin Microbiol Infect 21(12):1097.e1–1097.e4 CrossRef
Statistiska centralbyrån (SCB) (2016) Folkmängden efter region civilstånd, ålder och kön. År 1968–2015, updated 160222. Statistiska centralbyrån, Statistics Sweden. Available online at: http://www.statistikdatabasen.scb.se/pxweb/sv/ssd/START__BE__BE0101__BE0101A/BefolkningNy/table/tableViewLayout1/?rxid=634437cd-4d16-48f5-8168-17355fb9249c.
Brink M, Cronqvist J, Furebring M, Gille-Johnson P, Gårdlund B, Lanbeck P et al (2013) Svår sepsis och septisk chock—tidig identifiering och initial handläggning, updated December 2013. Programgrupp Sepsis. Available online at: http://www.infektion.net/sites/default/files/Sv%C3%A5r_sepsis_och_septisk_chock_dec_2013_new.pdf.
European Committee on Antimicrobial Susceptibility Testing (EUCAST) (2016) Breakpoint tables for interpretation of MICs and zone diameters. Version 6.0. Available online at: http://www.eucast.org/clinical_breakpoints/.
- Clinical and microbiological features of Actinotignum bacteremia: a retrospective observational study of 57 cases
- Springer Berlin Heidelberg
European Journal of Clinical Microbiology & Infectious Diseases
Print ISSN: 0934-9723
Elektronische ISSN: 1435-4373
Neu im Fachgebiet Innere Medizin
Meistgelesene Bücher aus der Inneren Medizin
Mail Icon II