Clinical and molecular features of patients with IDH1 wild-type primary glioblastoma presenting unexpected short-term survival after gross total resection
- 05.06.2024
- Research
Erschienen in:
- Verfasst von
- Mariko Toyoda
- Ichiyo Shibahara
- Ryota Shigeeda
- Kazuko Fujitani
- Yoko Tanihata
- Yuri Hyakutake
- Hajime Handa
- Hideto Komai
- Sumito Sato
- Madoka Inukai
- Takuichiro Hide
- Yoshiteru Shimoda
- Masayuki Kanamori
- Hidenori Endo
- Ryuta Saito
- Ken-Ichiro Matsuda
- Yukihiko Sonoda
- Toshihiro Kumabe
- Erschienen in
- Journal of Neuro-Oncology | Ausgabe 1/2024
Abstract
Background
This study investigated the factors influencing short-term survivors (STS) after gross total resection (GTR) in patients with IDH1 wild-type primary glioblastoma.
Methods
We analyzed five independent cohorts who underwent GTR, including 83 patients from Kitasato University (K-cohort), and four validation cohorts of 148 patients from co-investigators (V-cohort), 66 patients from the Kansai Molecular Diagnosis Network for the Central Nervous System tumors, 109 patients from the Cancer Genome Atlas, and 40 patients from the Glioma Longitudinal AnalySiS. The study defined STS as those who had an overall survival ≤ 12 months after GTR with subsequent radiation therapy, and concurrent and adjuvant temozolomide (TMZ).
Results
The study included 446 patients with glioblastoma. All cohorts experienced unexpected STS after GTR, with a range of 15.0–23.9% of the cases. Molecular profiling revealed no significant difference in major genetic alterations between the STS and non-STS groups, including MGMT, TERT, EGFR, PTEN, and CDKN2A. Clinically, the STS group had a higher incidence of non-local recurrence early in their treatment course, with 60.0% of non-local recurrence in the K-cohort and 43.5% in the V-cohort.
Conclusions
The study revealed that unexpected STS after GTR in patients with glioblastoma is not uncommon and such tumors tend to present early non-local recurrence. Interestingly, we did not find any significant genetic alterations in the STS group, indicating that such major alterations are characteristics of GB rather than being reliable predictors for recurrence patterns or development of unexpected STS.
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- Titel
- Clinical and molecular features of patients with IDH1 wild-type primary glioblastoma presenting unexpected short-term survival after gross total resection
- Verfasst von
-
Mariko Toyoda
Ichiyo Shibahara
Ryota Shigeeda
Kazuko Fujitani
Yoko Tanihata
Yuri Hyakutake
Hajime Handa
Hideto Komai
Sumito Sato
Madoka Inukai
Takuichiro Hide
Yoshiteru Shimoda
Masayuki Kanamori
Hidenori Endo
Ryuta Saito
Ken-Ichiro Matsuda
Yukihiko Sonoda
Toshihiro Kumabe
- Publikationsdatum
- 05.06.2024
- Verlag
- Springer US
- Erschienen in
-
Journal of Neuro-Oncology / Ausgabe 1/2024
Print ISSN: 0167-594X
Elektronische ISSN: 1573-7373 - DOI
- https://doi.org/10.1007/s11060-024-04687-2
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