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01.02.2014 | 2013 SSAT Poster Presentation | Ausgabe 2/2014

Journal of Gastrointestinal Surgery 2/2014

Clinical and Pathologic Features Influencing Survival in Patients Undergoing Pancreaticoduodenectomy for Pancreatic Adenocarcinoma

Zeitschrift:
Journal of Gastrointestinal Surgery > Ausgabe 2/2014
Autoren:
Cynthia E. Weber, Eileen A. Bock, Michael G. Hurtuk, Gerard J. Abood, Jack Pickleman, Margo Shoup, Gerard V. Aranha
Wichtige Hinweise
This study was presented at the 54th Annual Meeting of the Society for Surgery of the Alimentary Tract, Digestive Diseases Week 2013, Poster Presentation and the 47th Annual Pancreas Club Meeting, 2013, Poster of Distinction.

Abstract

Objective

The aim of the study was to determine the clinicopathological features that influence survival in patients with resected pancreatic ductal adenocarcinoma (PDA).

Methods

The study used a single institution retrospective review of patients undergoing pancreaticoduodenectomy (PD) for PDA from 1993 to 2010.

Results

Two hundred forty-six consecutive cases of resected PDA were identified: 128 males (52 %), median age 68 years. Median hospital length of stay was 8 days and 30-day mortality rate was 2.4 %. There were 101 (41.1 %) postoperative complications, 77 % of which were Dindo–Clavien Grade 3 or less. Overall survival was 85, 63, 25, and 15 % at 6 months, 1 year, 3 years, and 5 years, respectively, with a median survival of 17 months. Multivariate Cox proportional hazard modeling demonstrated lymph node ratio was negatively correlated with survival at all time points. Preoperative hypertension was a poor prognostic factor at 6 months, 3 years, and 5 years. The absence of postoperative complications was protective at 6 months whereas pancreatic leaks were associated with worse survival at 6 months. Abdominal pain on presentation, operative time, and estimated blood loss were also associated with decreased survival at various time points.

Conclusion

The strongest prognostic variable for short- and long-term survival after PD for PDA is lymph node ratio. Short-term survival is influenced by the postoperative course.

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