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Aesthetic Plastic Surgery
Erschienen in: Aesthetic Plastic Surgery 2/2018

02.02.2018 | Systemic Review

Clinical Application of Platelet-Rich Fibrin in Plastic and Reconstructive Surgery: A Systematic Review

verfasst von: Panxi Yu, Zhen Zhai, Xiaolei Jin, Xiaonan Yang, Zuoliang Qi

Erschienen in: Aesthetic Plastic Surgery | Ausgabe 2/2018

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Abstract

Background

Platelet-rich fibrin (PRF) has been applied in the clinical field for more than a decade, but largely in oral surgery and implant dentistry. Its utilization in plastic and reconstructive surgery is limited and lacking a comprehensive review. Hence, this article focuses on the various clinical applications of PRF pertaining to the plastic and reconstructive field through a systematic review.

Methods

In this review, articles describing the clinical application of PRF in plastic and reconstructive surgery were screened using predetermined inclusion and exclusion criteria. The articles were summarized and divided into groups based on the utilization of PRF. The effects and complications of PRF were analyzed and concluded.

Results

Among the 634 articles searched, 7 articles describing 151 cases are eligible. PRF was applied on 116 (76.8%) wounds to facilitate tissue healing, and the complete wound closure rate was 91.4% (106/116). Otherwise, PRF was applied in 10 (6.6%) cases of zygomaticomaxillary fracture to reconstruct orbital floor defects and in 25 (16.6%) cases of facial autologous fat grafts to increase the fat retention rate successfully. There is no report of PRF-related complications.

Conclusions

PRF could facilitate wound healing, including the healing of soft tissues and bony tissues, and facilitate fat survival rate. Further studies are needed to test the mechanism of PRF and expand its scope of application in plastic and reconstructive surgery.

Level of Evidence III

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.​springer.​com/​00266.
Literatur
1.
Fujita M, Horio T, Kishimoto S, Nakamura S, Takikawa M, Nakayama T, Yamamoto Y, Shimizu M, Hattori H, Tachibana S et al (2013) Effects of platelet-rich plasma-containing fragmin/protamine microparticles in enhancing endothelial and smooth muscle cell growth and inducing collateral vessels in a rabbit model of hindlimb ischemia. J Biomed Mater Res B Appl Biomater 101(1):36–42CrossRefPubMed
2.
Takikawa M, Nakamura S, Nakamura S, Nambu M, Ishihara M, Fujita M, Kishimoto S, Doumoto T, Yanagibayashi S, Azuma R et al (2011) Enhancement of vascularization and granulation tissue formation by growth factors in human platelet-rich plasma-containing fragmin/protamine microparticles. J Biomed Mater Res B Appl Biomater 97(2):373–380CrossRefPubMed
3.
Eppley BL, Woodell JE, Higgins J (2004) Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing. Plast Reconstr Surg 114(6):1502–1508CrossRefPubMed
4.
Weibrich G, Kleis WK, Hafner G, Hitzler WE (2002) Growth factor levels in platelet-rich plasma and correlations with donor age, sex, and platelet count. J Cranio-Maxillo-Fac Surg 30(2):97–102CrossRef
5.
Eppley BL, Pietrzak WS, Blanton M (2006) Platelet-rich plasma: a review of biology and applications in plastic surgery. Plast Reconstr Surg 118(6):147e–159eCrossRefPubMed
6.
Huang Y, Bornstein MM, Lambrichts I, Yu HY, Politis C, Jacobs R (2017) Platelet-rich plasma for regeneration of neural feedback pathways around dental implants: a concise review and outlook on future possibilities. Int J Oral Sci 9(1):1–9CrossRefPubMedPubMedCentral
7.
Dhurat R, Sukesh M (2014) Principles and methods of preparation of platelet-rich plasma: a review and author’s perspective. J Cutan Aesthet Surg 7(4):189–197CrossRefPubMedPubMedCentral
8.
Miao Y, Sun YB, Sun XJ, Du BJ, Jiang JD, Hu ZQ (2013) Promotional effect of platelet-rich plasma on hair follicle reconstitution in vivo. Dermatol Surg 39(12):1868–1876CrossRefPubMed
9.
Gentile P, Di Pasquali C, Bocchini I, Floris M, Eleonora T, Fiaschetti V, Floris R, Cervelli V (2013) Breast reconstruction with autologous fat graft mixed with platelet-rich plasma. Surg Innov 20(4):370–376CrossRefPubMed
10.
11.
Yang S, Wang M, Li J, Liu J, Lin X, Xu W (2012) The comparison of platelet-rich fibrin and platelet-rich plasma in releasing of growth factors and their effects on the proliferation and differentiation of adipose tissue-derived stem cells in vitro. West China J Stomatol 30(6):641–644, 649 (Chinese)
12.
Marx RE (2004) Platelet-rich plasma: evidence to support its use. J Oral Maxillofac Surg 62(4):489–496CrossRefPubMed
13.
Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, Gogly B (2006) Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101(3):e37–44CrossRefPubMed
14.
Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, Gogly B (2006) Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet-related biologic features. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101(3):e45–50CrossRefPubMed
15.
Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, Dohan AJ, Mouhyi J, Dohan DM (2006) Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101(3):e56–60CrossRefPubMed
16.
Liu B, Tan XY, Liu YP, Xu XF, Li L, Xu HY, An R, Chen FM (2013) The adjuvant use of stromal vascular fraction and platelet-rich fibrin for autologous adipose tissue transplantation. Tissue Eng C Methods 19(1):1–14CrossRef
17.
He L, Lin Y, Hu X, Zhang Y, Wu H (2009) A comparative study of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) on the effect of proliferation and differentiation of rat osteoblasts in vitro. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 108(5):707–713CrossRefPubMed
18.
Dohan Ehrenfest DM, Diss A, Odin G, Doglioli P, Hippolyte MP, Charrier JB (2009) In vitro effects of Choukroun’s PRF (platelet-rich fibrin) on human gingival fibroblasts, dermal prekeratinocytes, preadipocytes, and maxillofacial osteoblasts in primary cultures. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 108(3):341–352CrossRefPubMed
19.
Dohan Ehrenfest DM, de Peppo GM, Doglioli P, Sammartino G (2009) Slow release of growth factors and thrombospondin-1 in Choukroun’s platelet-rich fibrin (PRF): a gold standard to achieve for all surgical platelet concentrates technologies. Growth Factors 27(1):63–69CrossRefPubMed
20.
Wong CC, Chen CH, Chan WP, Chiu LH, Ho WP, Hsieh FJ, Chen YT, Yang TL: Single-stage cartilage repair using platelet-rich fibrin scaffolds with autologous cartilaginous grafts. Am J Sports Med 2017:363546517719876
21.
Naqvi A, Gopalakrishnan D, Bhasin MT, Sharma N, Haider K, Martande S (2017) Comparative evaluation of bioactive glass putty and platelet rich fibrin in the treatment of human periodontal intrabony defects: a randomized control trial. J Clin Diagn Res 11(7):ZC09–ZC13PubMedPubMedCentral
22.
Kumar A, Bains VK, Jhingran R, Srivastava R, Madan R, Rizvi I (2017) Patient-centered microsurgical management of gingival recession using coronally advanced flap with either platelet-rich fibrin or connective tissue graft: a comparative analysis. Contemp Clin Dent 8(2):293–304CrossRefPubMedPubMedCentral
23.
Pinto NR, Ubilla M, Zamora Y, Del Rio V, Dohan Ehrenfest DM, Quirynen M (2017) Leucocyte- and platelet-rich fibrin (L-PRF) as a regenerative medicine strategy for the treatment of refractory leg ulcers: a prospective cohort study. Platelets 1–8
24.
Chignon-Sicard B, Georgiou CA, Fontas E, David S, Dumas P, Ihrai T, Lebreton E (2012) Efficacy of leukocyte- and platelet-rich fibrin in wound healing: a randomized controlled clinical trial. Plast Reconstr Surg 130(6):819e–829eCrossRefPubMed
25.
Soyer T, Cakmak M, Aslan MK, Senyucel MF, Kisa U (2013) Use of autologous platelet rich fibrin in urethracutaneous fistula repair: preliminary report. Int Wound J 10(3):345–347CrossRefPubMed
26.
Guinot A, Arnaud A, Azzis O, Habonimana E, Jasienski S, Fremond B (2014) Preliminary experience with the use of an autologous platelet-rich fibrin membrane for urethroplasty coverage in distal hypospadias surgery. J Pediatr Urol 10(2):300–305CrossRefPubMed
27.
Cortese A, D’Alessio G, Brongo S, Gargiulo M, Claudio PP (2016) Management of zygomatic fractures in young patients: technical modifications for aesthetic and functional results. J Craniofac Surg 27(8):2073–2077CrossRefPubMed
28.
Cortese A, Caggiano M, Carlino F, Pantaleo G (2016) Zygomatic fractures: Technical modifications for better aesthetic and functional results in older patients. Int J Surg 33(Suppl 1):S9–S15CrossRefPubMed
29.
Keyhan SO, Hemmat S, Badri AA, Abdeshahzadeh A, Khiabani K (2013) Use of platelet-rich fibrin and platelet-rich plasma in combination with fat graft: which is more effective during facial lipostructure? J Oral Maxillofac Surg 71(3):610–621CrossRefPubMed
30.
Subramanian B, Krishnamurthy S, Suresh Kumar P, Saravanan B, Padhmanabhan M (2009) Comparison of various approaches for exposure of infraorbital rim fractures of zygoma. J Maxillofac Oral Surg 8(2):99–102CrossRefPubMedPubMedCentral
31.
Takabayashi Y, Ishihara M, Kuwabara M, Takikawa M, Nakamura S, Hattori H, Kiyosawa T (2017) Improved survival of full-thickness skin graft with low-molecular weight heparin-protamine micro/nanoparticles including platelet-rich plasma. Ann Plast Surg 78(5):562–568CrossRefPubMed
32.
Greer N, Foman NA, MacDonald R, Dorrian J, Fitzgerald P, Rutks I, Wilt TJ (2013) Advanced wound care therapies for nonhealing diabetic, venous, and arterial ulcers: a systematic review. Ann Intern Med 159(8):532–542CrossRefPubMed
33.
Everts PA, van Zundert A, Schonberger JP, Devilee RJ, Knape JT (2008) What do we use: platelet-rich plasma or platelet-leukocyte gel? J Biomed Mater Res A 85(4):1135–1136CrossRefPubMed
34.
Hibi H, Yamada Y, Ueda M, Endo Y (2006) Alveolar cleft osteoplasty using tissue-engineered osteogenic material. Int J Oral Maxillofac Surg 35(6):551–555CrossRefPubMed
35.
Magnani M, Trisolino G, Stilli S (2016) Refixation, allograft and adjuvant cell therapy to treat nonunion of the femoral neck in a child. Hip Int 26(6):e45–e48CrossRefPubMed
36.
Mazor Z, Horowitz RA, Del Corso M, Prasad HS, Rohrer MD, Dohan Ehrenfest DM (2009) Sinus floor augmentation with simultaneous implant placement using Choukroun’s platelet-rich fibrin as the sole grafting material: a radiologic and histologic study at 6 months. J Periodontol 80(12):2056–2064CrossRefPubMed
37.
38.
Hamed S, Egozi D, Kruchevsky D, Teot L, Gilhar A, Ullmann Y (2010) Erythropoietin improves the survival of fat tissue after its transplantation in nude mice. PLoS ONE 5(11):e13986CrossRefPubMedPubMedCentral
39.
Yoshimura K, Sato K, Aoi N, Kurita M, Hirohi T, Harii K (2008) Cell-assisted lipotransfer for cosmetic breast augmentation: supportive use of adipose-derived stem/stromal cells. Aesthet Plast Surg 32(1):48–55 (discussion 56-47) CrossRef
40.
Shoshani O, Livne E, Armoni M, Shupak A, Berger J, Ramon Y, Fodor L, Gilhar A, Peled IJ, Ullmann Y (2005) The effect of interleukin-8 on the viability of injected adipose tissue in nude mice. Plast Reconstr Surg 115(3):853–859CrossRefPubMed
41.
Serra-Mestre JM, Serra-Renom JM, Martinez L, Almadori A, D’Andrea F (2014) Platelet-rich plasma mixed-fat grafting: a reasonable prosurvival strategy for fat grafts? Aesthet Plast Surg 38(5):1041–1049CrossRef
42.
Cui D, Zhang T, Diao J, Yi C, Guo S (2013) Effect of platelet-rich fibrin on proliferation and adipogenic differentiation of adipose-derived stem cells. Chin J Med Aesth Cosmet 19(3):203–206 (Chinese)
43.
Huang M, Li H, Liang Z, Huang H, Zhang T, Li N, Chi G (2015) The effect of autologous platelet rich blood fibrin composite adipose-derived stem cells on the survival of autologous fat grafts. Chin J Exp Surg 32(12):3010–3015 (Chinese)
44.
Dohan Ehrenfest DM, Del Corso M, Diss A, Mouhyi J, Charrier JB (2010) Three-dimensional architecture and cell composition of a Choukroun’s platelet-rich fibrin clot and membrane. J Periodontol 81(4):546–555CrossRefPubMed
45.
O’Connell SM (2007) Safety issues associated with platelet-rich fibrin method. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103(5):587 (author reply 587-593) CrossRefPubMed
46.
Tunali M, Ozdemir H, Kucukodaci Z, Akman S, Yaprak E, Toker H, Firatli E (2014) A novel platelet concentrate: titanium-prepared platelet-rich fibrin. Biomed Res Int 2014:209548CrossRefPubMedPubMedCentral
47.
Tunali M, Ozdemir H, Kucukodaci Z, Akman S, Firatli E (2013) In vivo evaluation of titanium-prepared platelet-rich fibrin (T-PRF): a new platelet concentrate. Br J Oral Maxillofac Surg 51(5):438–443CrossRefPubMed
48.
Isobe K, Suzuki M, Watanabe T, Kitamura Y, Suzuki T, Kawabata H, Nakamura M, Okudera T, Okudera H, Uematsu K et al (2017) Platelet-rich fibrin prepared from stored whole-blood samples. Int J Implant Dent 3(1):6CrossRefPubMedPubMedCentral
49.
Bai MY, Wang CW, Wang JY, Lin MF, Chan WP (2017) Three-dimensional structure and cytokine distribution of platelet-rich fibrin. Clinics (Sao Paulo) 72(2):116–124CrossRef
50.
Nishimoto S, Fujita K, Sotsuka Y, Kinoshita M, Fujiwara T, Kawai K, Kakibuchi M (2015) Growth factor measurement and histological analysis in platelet rich fibrin: a pilot study. J Maxillofac Oral Surg 14(4):907–913CrossRefPubMedPubMedCentral
51.
Londahl M, Tarnow L, Karlsmark T, Lundquist R, Nielsen AM, Michelsen M, Nilsson A, Zakrzewski M, Jorgensen B (2015) Use of an autologous leucocyte and platelet-rich fibrin patch on hard-to-heal DFUs: a pilot study. J Wound Care 24(4):172–174–176–178CrossRef
52.
Sclafani AP, McCormick SA (2012) Induction of dermal collagenesis, angiogenesis, and adipogenesis in human skin by injection of platelet-rich fibrin matrix. Arch Fac Plast Surg 14(2):132–136CrossRef
53.
Danielsen PL, Agren MS, Jorgensen LN (2010) Platelet-rich fibrin versus albumin in surgical wound repair: a randomized trial with paired design. Ann Surg 251(5):825–831CrossRefPubMed
54.
O’Connell SM, Impeduglia T, Hessler K, Wang XJ, Carroll RJ, Dardik H (2008) Autologous platelet-rich fibrin matrix as cell therapy in the healing of chronic lower-extremity ulcers. Wound Repair Regen 16(6):749–756CrossRefPubMed
55.
Danielsen P, Jorgensen B, Karlsmark T, Jorgensen LN, Agren MS (2008) Effect of topical autologous platelet-rich fibrin versus no intervention on epithelialization of donor sites and meshed split-thickness skin autografts: a randomized clinical trial. Plast Reconstr Surg 122(5):1431–1440CrossRefPubMed
Metadaten
Titel
Clinical Application of Platelet-Rich Fibrin in Plastic and Reconstructive Surgery: A Systematic Review
verfasst von
Panxi Yu
Zhen Zhai
Xiaolei Jin
Xiaonan Yang
Zuoliang Qi
Publikationsdatum
02.02.2018
Verlag
Springer US
Erschienen in
Aesthetic Plastic Surgery / Ausgabe 2/2018
Print ISSN: 0364-216X
Elektronische ISSN: 1432-5241
DOI
https://doi.org/10.1007/s00266-018-1087-0

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