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01.12.2017 | Review | Ausgabe 1/2017 Open Access

European Journal of Medical Research 1/2017

Clinical application prospect of umbilical cord-derived mesenchymal stem cells on clearance of advanced glycation end products through autophagy on diabetic wound

Zeitschrift:
European Journal of Medical Research > Ausgabe 1/2017
Autoren:
Yanfu Han, Tianjun Sun, Ran Tao, Yanqing Han, Jing Liu
Wichtige Hinweise
Yanfu Han, Tianjun Sun, and Ran Tao should be regarded as co-first authors

Abstract

Nowadays, wound healing delay due to diabetes is considered to be closely related to the accumulation of advanced glycation end products (AGEs). Although mesenchymal stem cells (MSCs) exhibit positive effects on diabetic wound healing, related mechanisms are still not fully elucidated. It has been reported that MSCs can improve the activity of autophagy in injured tissues, thereby playing an important role in wound healing. The autophagy induced by MSCs may be beneficial to diabetic wound healing via removing AGEs, which provide new ideas for clinical treatment of diabetic wounds with the potential of broad application prospects. In this study, the current research situation and application prospect of umbilical cord-derived MSCs on the clearance of AGEs in diabetic wound were reviewed.
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