The online version of this article (doi:10.1186/s12902-015-0018-1) contains supplementary material, which is available to authorized users.
Shuang Zheng and Huan Zhou contributed equally to this work.
The authors declare that they have no competing interests.
SZ and HZ collected, researched, and discussed the data and wrote, reviewed, and edited the manuscript. TTH and YXL contributed to discussion and reviewed and edited the manuscript. YZ researched the data, contributed to the discussion, and reviewed and edited the manuscript. WL contributed to the discussion, and reviewed and edited the manuscript. YMH collected and researched the data, contributed to the discussion, and reviewed and edited the manuscript. YMH is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. All authors read and approved the final manuscript.
To explore clinical characteristics and beta cell function in Chinese patients with newly diagnosed drug naive type 2 diabetes mellitus (T2DM) with different levels of serum triglyceride (TG).
Patients with newly diagnosed T2DM (n = 624) were enrolled and divided into different groups according to levels of serum TG. All patients underwent oral glucose tolerance tests and insulin releasing tests. Demographic data, lipid profiles, glucose levels, and insulin profiles were compared between different groups. Basic insulin secretion function index (homeostasis model assessment for beta cell function index, HOMA-β), modified beta cell function index (MBCI), glucose disposition indices (DI), and early insulin secretion function index (insulinogenic index, IGI) were used to evaluate the beta cell function.
Patients of newly diagnosed T2DM with hypertriglyceridemia were younger, fatter and had worse lipid profiles, glucose profiles, and high insulin levels than those with normal TG. There is no difference in early phase insulin secretion among groups of newly diagnosed T2DM patients with different TG levels. The basal beta cell function (HOMA-β and MBCI) initially increased along rising TG levels and then decreased as the TG levels rose further. The insulin sensitivity was relatively high in patients with a low level of TG and low with a high level of TG.
Hypertriglyceridemia influences clinical characteristics and β cell function of Chinese patients with newly diagnosed T2DM. A better management of dyslipidemia may, to some extent, reduce the effect of lipotoxicity, thereby improving glucose homeostasis in patients with newly diagnosed T2DM.
Additional file 1: STROBE Statement—checklist of items that should be included in reports of observational studies.12902_2015_18_MOESM1_ESM.docx
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