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03.02.2017 | Original Article

Clinical characteristics of pediatric HIV-1 patients treated with first-line antiretroviral therapy in Vietnam: a nested case–control study

verfasst von: Minh Diem Dang, Duc Minh Nguyen, Huu Bich Tran, Viet Hung Pham, Daryl Spak, Linh Chi Pham, Thi Quynh Phan, Thi Thanh Dinh, Thi Kim Anh Le, Van Lam Nguyen, Thanh Hai Le, Son Ngoc Hoang, Vu Phuong Linh Dang

Erschienen in: International Journal of Public Health | Sonderheft 1/2017

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Abstract

Objectives

Over the past decades, Vietnam has made great strides in reducing the rate of mortality in HIV-related deaths, due to increased access of antiretroviral therapy (ART); however, given the significantly high level of treatment failure (TF), it is essential to identify markers that describe the failure of ART in HIV-1 infected children.

Methods

A nested case–control study was conducted with clinical data collected from 101 HIV-infected children [26 TF and 75 treatment success (TS)] at National Hospital of Pediatrics, Vietnam (2008–2012).

Results

The results showed that certain factors including height, weight, vaccination with Hepatitis B, and platelet were significantly different between TF and TS before starting the treatment. In addition, age to start the treatment, CD4 percentage, and opportunistic infection were found to significantly predict treatment outcome most frequently, implying the importance of clinical markers in the treatment response by Cox regression analysis.

Conclusions

There is an inherent complexity within clinical markers that is challenging to determine HIV-pediatric failure and further research is needed to build a complete picture to guide clinical, evidence-based practice.

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Titel: Clinical characteristics of pediatric HIV-1 patients treated with first-line antiretroviral therapy in Vietnam: a nested case–control study
verfasst von: Minh Diem Dang
Duc Minh Nguyen
Huu Bich Tran
Viet Hung Pham
Daryl Spak
Linh Chi Pham
Thi Quynh Phan
Thi Thanh Dinh
Thi Kim Anh Le
Van Lam Nguyen
Thanh Hai Le
Son Ngoc Hoang
Vu Phuong Linh Dang
Publikationsdatum: 03.02.2017
Verlag: Springer International Publishing
Erschienen in: International Journal of Public Health / Ausgabe Sonderheft 1/2017
Print ISSN: 1661-8556
Elektronische ISSN: 1661-8564
DOI: https://doi.org/10.1007/s00038-016-0937-2

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Clinical characteristics of pediatric HIV-1 patients treated with first-line antiretroviral therapy in Vietnam: a nested case–control study

Abstract

Objectives

Methods

Results

Conclusions

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Objectives

Methods

Results

Conclusions

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