The online version of this article (doi:10.1186/1477-7819-10-175) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
TL conducted the clinical assessments, analyzed and interpreted data and wrote the first draft; YSL, SYY, SJK, YJB and HSK contributed to data collection and interpretation; YSC and HBM advised on and helped with the study design, contributed to data analysis and interpretation; TBK conceived the study and design, advised on and helped with study design, discussed core ideas, designed data collection protocols, and helped with data interpretation and writing. All authors read and approved the final manuscript.
When new space-occupying lesions are observed together with peripheral blood eosinophilia in patients diagnosed with cancer, the possibility of eosinophilic organ involvement should be differentiated from metastasis of primary cancer, since a misdiagnosis could lead to unnecessary chemotherapy. The aim of this study is to identify the clinical characteristics of eosinophilic organ involvement that distinguish it from distant metastasis in patients with primary cancer.
The medical records of 43 cancer patients who developed hepatic or pulmonary nodules with peripheral blood eosinophilia between January 2005 and February 2010 in the Asan Medical Center (Seoul) were reviewed. Eosinophilic infiltration and distant metastasis were identified on the basis of pathological findings and radiological features. Fisher’s exact test, χ2 test or Mann-Whitney test were used for statistical analysis.
In total, 33 patients (76%) were diagnosed with eosinophilic infiltration, 5 (12%) with cancer metastasis and 5 (12%) had undetermined diagnoses. Compared to the patients with metastases, the patients with eosinophilic infiltration were significantly more likely to have serology indicating a parasitic infection, a history of eating raw food, high serum levels of total IgE, normal liver function, normal C-reactive protein levels, a normal erythrocyte sedimentation rate, and fewer and smaller nodules. The most common underlying malignancy in the eosinophilic organ infiltration group was stomach cancer. Physicians tended to neglect the eosinophilia in patients with a history of cancer.
Several clinical characteristics of eosinophilic organ infiltration distinguish it from cancer metastasis. Physicians should make greater efforts to determine the causes of organ involvement with peripheral blood eosinophilia, especially in cancer patients.
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- Clinical characteristics that distinguish eosinophilic organ infiltration from metastatic nodule development in cancer patients with eosinophilia
Yoon Su Lee
Sun Young Yoon
You Sook Cho
- BioMed Central
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