Background
Materials and methods
Subjects
Therapeutic method
Outcome measures
Evaluation criteria
Statistical analyses
Results
Analysis of baseline data
Group | Control group (n = 43) | Observation group (n = 134) | t/χ2 |
P
|
---|---|---|---|---|
Gender (male / female) | 26/17 | 73/61 | 0.668 | 0.491 |
Age (year) | 46.7 ± 5.3 | 45.2 ± 4.8 | 1.739 | 0.084 |
Weight (kg) | 57.37 ± 6.72 | 58.51 ± 7.29 | 0.909 | 0.365 |
BMI (kg/m2) | 23.28 ± 3.83 | 21.36 ± 4.32 | 2.604 | 0.010 |
Nutritional status (n) | 1.801 | 0.072 | ||
Good | 16 | 63 | ||
Poor | 27 | 71 | ||
Airway obstruction (n) | 2.879 | 0.004 | ||
Mild | 14 | 31 | ||
Severe | 29 | 103 | ||
Site of airway obstruction (n) | 0.505 | 0.613 | ||
Trachea | 18 | 62 | ||
Right and left main bronchus | 25 | 72 | ||
Pathological type (n) | 0.513 | 0.736 | ||
Squamous cell carcinoma | 11 | 28 | ||
Adenocarcinoma | 15 | 37 | ||
Large cell carcinoma | 12 | 42 | ||
Small cell carcinoma | 5 | 27 | ||
Concomitant disease (n, %) | ||||
Hypertension | 13 (30.23%) | 65 (48.51%) | 2.100 | 0.036 |
Anemia | 14 (32.56%) | 36 (26.87%) | 0.721 | 0.471 |
TNM staging (n) | 0.348 | 0.625 | ||
II | 7 | 21 | ||
III | 14 | 48 | ||
IV | 22 | 65 |
Group | Control group (n = 43) | Observation group (n = 43) | t/χ2 |
P
|
---|---|---|---|---|
Sex (male / female) | 26/17 | 23/20 | 0.653 | 0.514 |
Age (year) | 46.7 ± 5.3 | 47.4 ± 6.1 | 0.518 | 0.606 |
Weight (kg) | 57.37 ± 6.72 | 59.21 ± 7.16 | 1.229 | 0.223 |
BMI (kg/m2) | 23.28 ± 3.83 | 24.42 ± 4.64 | 1.423 | 0.218 |
Nutritional status (n) | 0.684 | 0.494 | ||
Good | 16 | 13 | ||
Poor | 27 | 30 | ||
Airway obstruction (n) | 0.453 | 0.651 | ||
Mild | 14 | 16 | ||
Severe | 29 | 27 | ||
Site of airway obstruction (n) | 1.841 | 0.065 | ||
Trachea | 18 | 10 | ||
Right and left main bronchus | 25 | 33 | ||
Pathological type (n) | 0.434 | 0.805 | ||
Squamous cell carcinoma | 11 | 10 | ||
Adenocarcinoma | 15 | 13 | ||
Large cell carcinoma | 12 | 14 | ||
Small cell carcinoma | 5 | 6 | ||
Concomitant disease (n, %) | ||||
Hypertension | 13 (30.23) | 12 (27.91) | 0.238 | 0.812 |
Anemia | 14 (32.56) | 13 (30.23) | 0.232 | 0.816 |
TNM staging (n) | 0.632 | 0.729 | ||
II | 7 | 9 | ||
III | 14 | 11 | ||
IV | 22 | 23 |
Comparison of airway diameter and dyspnea index
Comparison of Karnofsky score
Arterial blood-gas analysis
Group | Time | PaO2 (mmHg) | PaCO2 (mmHg) | SaO2 (%) |
---|---|---|---|---|
Control group | Before treatment | 54.36 ± 4.63 | 43.46 ± 3.37 | 82.46 ± 5.73 |
After treatment | 64.23 ± 4.62* | 39.24 ± 3.12* | 91.36 ± 8.64* | |
Observation group | Before treatment | 56.37 ± 5.13 | 44.51 ± 4.42 | 83.72 ± 5.48 |
After treatment | 73.29 ± 6.27*# | 34.26 ± 3.17*# | 97.34 ± 9.24*# |
Comparison of effective rate
Group | Completely effective | Partially effective | Mildly effective | Ineffective |
---|---|---|---|---|
Control group (n = 43) | 7 (16.28) | 17 (39.53) | 15 (34.88) | 4 (9.31) |
Observation group (n = 43) | 16 (37.21) | 20 (46.51) | 5 (11.63) | 2 (4.65) |
χ2 | 2.193 | 0.653 | 2.553 | 0.847 |
P
| 0.028 | 0.514 | 0.011 | 0.392 |
Comparison of post-treatment adverse reactions
Group | Hypoxia | Bleeding | Arrhythmia | Fever |
---|---|---|---|---|
Control group (n = 43) | 6 (13.95) | 13 (30.23) | 14 (32.56) | 17 (39.53) |
Observation group (n = 43) | 7 (16.28) | 5 (11.63) | 6 (13.95) | 8 (18.60) |
χ2 | 0.301 | 2.121 | 2.042 | 2.137 |
P
| 0.763 | 0.034 | 0.041 | 0.033 |