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Graefe's Archive for Clinical and Experimental Ophthalmology

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16.03.2016 | Retinal Disorders

Clinical efficiency of Helicobacter pylori eradication in the treatment of patients with acute central serous chorioretinopathy

verfasst von: Olesya Zavoloka, Pavlo Bezditko, Irina Lahorzhevska, Darya Zubkova, Yevgeniya Ilyina

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 9/2016

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Abstract

Background

Although the majority of cases of acute central serous chorioretinopathy are self-limited, resolving spontaneously after a number of weeks, the recurrence rate is estimated to be 20–50 %, and some cases will be chronic, lasting 6 months or longer. The evidence of Helicobacter pylori infection appears more often in patients with central serous chorioretinopathy. The purpose of this work was to estimate the efficiency of H. pylori infection eradication in treatment of patients with acute central serous chorioretinopathy.

Methods

Ninety-three patients with acute central serous chorioretinopathy participated in this study. Patients were divided into an experimental group (33 Helicobacter pylori-positive patients who received eradication treatment) and two control groups who did not receive eradication treatment: 29 H. pylori-positive patients and 31 H. pylori-negative patients. Research methods were best-corrected Snellen visual acuity, optical coherence tomography, fluorescein angiography. Research methods were best-corrected Snellen visual acuity, optical coherence tomography, static perimetry, and Amsler grid. The follow-up period was 2 years.

Results

Helicobacter pylori eradication caused a decrease of disease duration at 3 months (p = 0.04) and recurrence frequency of 45.6 % (p = 0.03) as well as improvement of distant prognosis. After 2 years, visual acuity increased from 0.91 ± 0.07 to 0.99 ± 0.02 (p = 0.01), scotoma frequency decreased from 100 % eyes to 27.2 % (p = 0.001), and metamorphopsia frequency decreased from 57.6 % eyes to 39.4 % (p = 0.04).

Conclusions

Helicobacter pylori eradication is effective in the treatment of H. pylori-positive patients with acute central serous chorioretinopathy.

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Titel: Clinical efficiency of Helicobacter pylori eradication in the treatment of patients with acute central serous chorioretinopathy
verfasst von: Olesya Zavoloka
Pavlo Bezditko
Irina Lahorzhevska
Darya Zubkova
Yevgeniya Ilyina
Publikationsdatum: 16.03.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 9/2016
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-016-3315-0

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Springer Medizin

Clinical efficiency of Helicobacter pylori eradication in the treatment of patients with acute central serous chorioretinopathy

Abstract

Background

Methods

Results

Conclusions

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Springer Medizin

Abstract

Background

Methods

Results

Conclusions

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