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12.08.2020 | Original Article

Clinical features and expression of type I interferon-inducible genes in systemic lupus erythematosus patients harboring rs1143679 polymorphism in China: a single-center, retrospective study

verfasst von: Wenyu Xu, Yueyue Zhang, Xiaoqin Wang, Peiyu Liu, Dayu Gao, Bingjie Gu, Junyu Zhang, Chunmei Li, Qijie Ren, Leilei Yang, Hai Yuan, Minning Shen, Xingguo Chen

Erschienen in: Clinical Rheumatology | Ausgabe 3/2021

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Abstract

Objective

This case-control study aimed to analyze the clinical features and determine the expression of type I interferon-induced genes in systemic lupus erythematosus (SLE) patients harboring the CD11b rs1143679 single-nucleotide polymorphism (SNP) and elucidate whether it is involved in the relapses of SLE.

Methods

One hundred twenty-five relatively inactive SLE patients with SLEDAI scores < 6, including 102 CD11b rs1143679 G allele patients as controls and 23 rs1143679 A allele carriers as cases, were enrolled from the SLE patient specimen bank in the Department of Rheumatology and Immunology. The sample set was retrospectively analyzed for differences in clinical features, and quantitative PCR and Western blot analyses were performed to evaluate the relative expression of type I interferon (IFN)-inducible genes.

Results

The 24-h urinary protein levels in the case group were significantly elevated, and serum C3 levels were significantly reduced compared with those in the control group (P = 0.019 and P = 0.021, respectively). The relative mRNA levels of IFN-inducible genes IFIT1, IFIT4, and ISG15 in the case group were higher than that in the control group (P = 0.0257, 0.0344, and 0.0311, respectively) and matched with the Western blot results.

Conclusions

The relative expression of type I IFN-inducible genes in inactive SLE patients harboring the CD11b rs1143679 polymorphism was higher than that in other lupus patients. These findings suggest that the rs1143679 SNP can precipitate relapses in inactive SLE patients.

Key Points

• The rs1143679 GA genotype was associated with SLE clinical features.

• The rs1143679 GA genotype showed higher interferon-inducible gene expression relative to the GG genotype.

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Titel: Clinical features and expression of type I interferon-inducible genes in systemic lupus erythematosus patients harboring rs1143679 polymorphism in China: a single-center, retrospective study
verfasst von: Wenyu Xu
Yueyue Zhang
Xiaoqin Wang
Peiyu Liu
Dayu Gao
Bingjie Gu
Junyu Zhang
Chunmei Li
Qijie Ren
Leilei Yang
Hai Yuan
Minning Shen
Xingguo Chen
Publikationsdatum: 12.08.2020
Verlag: Springer International Publishing
Erschienen in: Clinical Rheumatology / Ausgabe 3/2021
Print ISSN: 0770-3198
Elektronische ISSN: 1434-9949
DOI: https://doi.org/10.1007/s10067-020-05330-x

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Clinical features and expression of type I interferon-inducible genes in systemic lupus erythematosus patients harboring rs1143679 polymorphism in China: a single-center, retrospective study

Abstract

Objective

Methods

Results

Conclusions

Key Points

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

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Abstract

Objective

Methods

Results

Conclusions

Key Points

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