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Erschienen in: Journal of Neurology 5/2020

13.01.2020 | Original Communication

Clinical features and prognosis of late-onset neuromyelitis optica spectrum disorders in a Latin American cohort

verfasst von: Edgar Carnero Contentti, Vanessa Daccach Marques, Ibis Soto de Castillo, Verónica Tkachuk, Bustos Ariel, Maria C. Castillo, Edgardo Cristiano, Gabriel Braga Diégues Serva, Antonio Carlos dos Santos, Ana Mariel Finkelsteyn, Pablo A. López, Liliana Patrucco, Omaira Molina, Juan Pablo Pettinicchi, Vanesa Toneguzzo, Alejandro Caride, Juan Ignacio Rojas

Erschienen in: Journal of Neurology | Ausgabe 5/2020

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Abstract

Background

We aimed to assess the clinical, paraclinical, imaging and prognostic features of patients with late-onset neuromyelitis optica spectrum disorder (LO-NMOSD; ≥ 50 years at disease onset) LO-NMOSD, compared with early onset-NMOSD (EO-NMOSD, ≤ 49 years at disease onset), in Latin American (LATAM).

Methods

We retrospectively reviewed the medical records of patients with NMOSD, as defined using the 2015 validated diagnostic criteria. We included patients from Argentina, Brazil and Venezuela. They were divided into: LO-NMOSD and EO-NMOSD and comparison among the groups were performed.

Results

Among these 140 NMOSD patients, 24 (17.1%) were LO-NMOSD; 64% were positive for aquaporin-4 antibodies; and 41.5% of this population cohort was non-Caucasian. Severe disability [expanded disability status scale (EDSS) ≥ 6] at the last follow-up and presence of comorbidities were significantly associated with LO-NMOSD, compared with EO-NMOSD. LO-NMOSD patients had a shorter median time to EDSS ≥ 4 than EO-NMOSD patients (46 vs. 60 months; log-rank test p = 0.0006). Furthermore, we observed a positive correlation between age at onset and EDSS score at the last follow-up (Spearman r = 0.34, p < 0.0001).

Conclusion

LO-NMOSD patients from LATAM developed early severe disability, compared with EO-NMOSD. Therefore, age at onset could have important implications for the long-term prognosis of NMOSD patients.
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Metadaten
Titel
Clinical features and prognosis of late-onset neuromyelitis optica spectrum disorders in a Latin American cohort
verfasst von
Edgar Carnero Contentti
Vanessa Daccach Marques
Ibis Soto de Castillo
Verónica Tkachuk
Bustos Ariel
Maria C. Castillo
Edgardo Cristiano
Gabriel Braga Diégues Serva
Antonio Carlos dos Santos
Ana Mariel Finkelsteyn
Pablo A. López
Liliana Patrucco
Omaira Molina
Juan Pablo Pettinicchi
Vanesa Toneguzzo
Alejandro Caride
Juan Ignacio Rojas
Publikationsdatum
13.01.2020
Verlag
Springer Berlin Heidelberg
Erschienen in
Journal of Neurology / Ausgabe 5/2020
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-020-09699-2