Clinical features and visual prognosis of very late-onset neuromyelitis optica spectrum disorder–related optic neuritis
- 20.11.2023
- Original Article
Erschienen in:
- Verfasst von
- Qinglin Yang
- Chuntao Lai
- Chao Meng
- Qinglin Chang
- Na Wei
- Jiawei Wang
- Erschienen in
- Neurological Sciences | Ausgabe 5/2024
Abstract
Background
Very late-onset neuromyelitis optica spectrum disorder–related optic neuritis is limited to a few case reports.
Objective
To investigate the clinical features and visual prognosis of very late-onset neuromyelitis optica spectrum disorder–related optic neuritis.
Methods
This study evaluated 22 patients with first-onset optic neuritis and fulfilled the 2015 diagnosis criteria for neuromyelitis optica spectrum disorders.
Results
The mean age at optic neuritis onset was 73.91 ± 4.71 (range: 70–82) years with a female predominance (81.8%; ratio: 4.5:1). Antinuclear antibody seropositivity and seronegativity were identified in 12 (55.5%) and 10 (45.5%) patients, respectively. Severe visual loss persisted in 19 (19/42, 45.3%) eyes at the last follow-up. Although patients with antinuclear antibody seropositivity had a significantly higher frequency of attacks (P = 0.015), but they had a longer median time to reach severe visual loss (37 vs. 26 months; log-rank test, P = 0.023). Multivariate logistic regression analysis revealed antinuclear antibody seropositivity (hazard ratio = 4.849, 95% confidence interval: 1.309–17.965, P = 0.018) as a good predictor of visual acuity improvement.
Conclusion
Patients with very late-onset neuromyelitis optica spectrum disorder–related optic neuritis may develop severe optic neuritis, and those with antinuclear antibody seronegativity have a similar clinical presentation but worse outcome than those with seropositivity.
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- Titel
- Clinical features and visual prognosis of very late-onset neuromyelitis optica spectrum disorder–related optic neuritis
- Verfasst von
-
Qinglin Yang
Chuntao Lai
Chao Meng
Qinglin Chang
Na Wei
Jiawei Wang
- Publikationsdatum
- 20.11.2023
- Verlag
- Springer International Publishing
- Erschienen in
-
Neurological Sciences / Ausgabe 5/2024
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478 - DOI
- https://doi.org/10.1007/s10072-023-07187-9
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