Skip to main content
Erschienen in: Journal of NeuroVirology 6/2017

11.09.2017 | Short Communication

Clinical manifestations and treatment outcomes of parvovirus B19 encephalitis in immunocompetent adults

verfasst von: Jin-Sun Jun, Jangsup Moon, Jung-Ick Byun, Jun-Sang Sunwoo, Jung-Ah Lim, Soon-Tae Lee, Keun-Hwa Jung, Kyung-Il Park, Ki-Young Jung, Manho Kim, Sang Kun Lee, Kon Chu

Erschienen in: Journal of NeuroVirology | Ausgabe 6/2017

Einloggen, um Zugang zu erhalten

Abstract

Parvovirus B19 (PVB19) has rarely been identified as a cause of encephalitis in immunocompetent adults, in whom clinical information regarding PVB19 encephalitis has remained unclear. Herein, we report the clinical presentations, laboratory and imaging findings, and treatment outcomes of five immunocompetent adults with PVB19 encephalitis. Although none of the patients showed any distinctive features of PVB19 infection, they showed various clinical manifestations, including one instance of brainstem involvement. Additionally, immunotherapy can be considered an effective approach, especially in immunocompetent adults with PVB19 encephalitis who are resistant to the initial management.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
Zurück zum Zitat Barah F, Vallely PJ, Cleator GM, Kerr JR (2003) Neurological manifestations of human parvovirus B19 infection. Rev Med Virol 13(3):185–199CrossRefPubMed Barah F, Vallely PJ, Cleator GM, Kerr JR (2003) Neurological manifestations of human parvovirus B19 infection. Rev Med Virol 13(3):185–199CrossRefPubMed
Zurück zum Zitat Barah F, Whiteside S, Batista S, Morris J (2014) Neurological aspects of human parvovirus B19 infection: a systematic review. Rev Med Virol 24(3):154–168CrossRefPubMedPubMedCentral Barah F, Whiteside S, Batista S, Morris J (2014) Neurological aspects of human parvovirus B19 infection: a systematic review. Rev Med Virol 24(3):154–168CrossRefPubMedPubMedCentral
Zurück zum Zitat Cossart YE, Field AM, Cant B, Widdows D (1975) Parvovirus-like particles in human sera. Lancet 1(7898):72–73CrossRefPubMed Cossart YE, Field AM, Cant B, Widdows D (1975) Parvovirus-like particles in human sera. Lancet 1(7898):72–73CrossRefPubMed
Zurück zum Zitat Douvoyiannis M, Litman N, Goldman DL (2009) Neurologic manifestations associated with parvovirus B19 infection. Clin Infect Dis 48(12):1713–1723CrossRefPubMed Douvoyiannis M, Litman N, Goldman DL (2009) Neurologic manifestations associated with parvovirus B19 infection. Clin Infect Dis 48(12):1713–1723CrossRefPubMed
Zurück zum Zitat Farrell B, Godwin J, Richards S, Warlow C (1991) The United Kingdom transient ischaemic attack (UK-TIA) aspirin trial: final results. J Neurol Neurosurg Psychiatry 54(12):1044–1054CrossRefPubMedPubMedCentral Farrell B, Godwin J, Richards S, Warlow C (1991) The United Kingdom transient ischaemic attack (UK-TIA) aspirin trial: final results. J Neurol Neurosurg Psychiatry 54(12):1044–1054CrossRefPubMedPubMedCentral
Zurück zum Zitat Jubelt B, Mihai C, Li TM, Veerapaneni P (2011) Rhombencephalitis/brainstem encephalitis. Curr Neurol Neurosci Rep 11(6):543–552CrossRefPubMed Jubelt B, Mihai C, Li TM, Veerapaneni P (2011) Rhombencephalitis/brainstem encephalitis. Curr Neurol Neurosci Rep 11(6):543–552CrossRefPubMed
Zurück zum Zitat Kerr JR, Barah F, Chiswick ML, McDonnell GV, Smith J, Chapman MD, Bingham JB, Kelleher P, Sheppard MN (2002) Evidence for the role of demyelination, HLA-DR alleles, and cytokines in the pathogenesis of parvovirus B19 meningoencephalitis and its sequelae. J Neurol Neurosurg Psychiatry 73(6):739–746CrossRefPubMedPubMedCentral Kerr JR, Barah F, Chiswick ML, McDonnell GV, Smith J, Chapman MD, Bingham JB, Kelleher P, Sheppard MN (2002) Evidence for the role of demyelination, HLA-DR alleles, and cytokines in the pathogenesis of parvovirus B19 meningoencephalitis and its sequelae. J Neurol Neurosurg Psychiatry 73(6):739–746CrossRefPubMedPubMedCentral
Zurück zum Zitat Lee D-S, Lee J-H, Huh S-Y, Kim MJ, Kim M-K, Yoo B-G (2015) Meningoencephalitis associated with parvovirus B19 infection in an immunocompetent patient. Kosin Med J 30(2):181–185CrossRef Lee D-S, Lee J-H, Huh S-Y, Kim MJ, Kim M-K, Yoo B-G (2015) Meningoencephalitis associated with parvovirus B19 infection in an immunocompetent patient. Kosin Med J 30(2):181–185CrossRef
Zurück zum Zitat Moretti M, Abbate I, Sciarrone M, Guercini G, Francisci D, Pelliccioli G, Baldelli F (2008) Acute infection with parvovirus B19 manifesting as brain stem encephalitis. Infect Med 25(4):173–179 Moretti M, Abbate I, Sciarrone M, Guercini G, Francisci D, Pelliccioli G, Baldelli F (2008) Acute infection with parvovirus B19 manifesting as brain stem encephalitis. Infect Med 25(4):173–179
Zurück zum Zitat Pillai SC, Hacohen Y, Tantsis E, Prelog K, Merheb V, Kesson A, Barnes E, Gill D, Webster R, Menezes M, Ardern-Holmes S, Gupta S, Procopis P, Troedson C, Antony J, Ouvrier RA, Polfrit Y, Davies NW, Waters P, Lang B, Lim MJ, Brilot F, Vincent A, Dale RC (2015) Infectious and autoantibody-associated encephalitis: clinical features and long-term outcome. Pediatrics 135(4):974–984CrossRef Pillai SC, Hacohen Y, Tantsis E, Prelog K, Merheb V, Kesson A, Barnes E, Gill D, Webster R, Menezes M, Ardern-Holmes S, Gupta S, Procopis P, Troedson C, Antony J, Ouvrier RA, Polfrit Y, Davies NW, Waters P, Lang B, Lim MJ, Brilot F, Vincent A, Dale RC (2015) Infectious and autoantibody-associated encephalitis: clinical features and long-term outcome. Pediatrics 135(4):974–984CrossRef
Zurück zum Zitat Skaff PT, Labiner DM (2001) Status epilepticus due to human parvovirus B19 encephalitis in an immunocompetent adult. Neurology 57(7):1336–1337CrossRefPubMed Skaff PT, Labiner DM (2001) Status epilepticus due to human parvovirus B19 encephalitis in an immunocompetent adult. Neurology 57(7):1336–1337CrossRefPubMed
Zurück zum Zitat Tan IL, Mowry EM, Steele SU, Pardo CA, McArthur JC, Nath A, Venkatesan A (2013) Brainstem encephalitis: etiologies, treatment, and predictors of outcome. J Neurol 260(9):2312–2319CrossRefPubMedPubMedCentral Tan IL, Mowry EM, Steele SU, Pardo CA, McArthur JC, Nath A, Venkatesan A (2013) Brainstem encephalitis: etiologies, treatment, and predictors of outcome. J Neurol 260(9):2312–2319CrossRefPubMedPubMedCentral
Zurück zum Zitat Thakur KT, Motta M, Asemota AO, Kirsch HL, Benavides DR, Schneider EB, McArthur JC, Geocadin RG, Venkatesan A (2013) Predictors of outcome in acute encephalitis. Neurology 81:793–800CrossRefPubMedPubMedCentral Thakur KT, Motta M, Asemota AO, Kirsch HL, Benavides DR, Schneider EB, McArthur JC, Geocadin RG, Venkatesan A (2013) Predictors of outcome in acute encephalitis. Neurology 81:793–800CrossRefPubMedPubMedCentral
Metadaten
Titel
Clinical manifestations and treatment outcomes of parvovirus B19 encephalitis in immunocompetent adults
verfasst von
Jin-Sun Jun
Jangsup Moon
Jung-Ick Byun
Jun-Sang Sunwoo
Jung-Ah Lim
Soon-Tae Lee
Keun-Hwa Jung
Kyung-Il Park
Ki-Young Jung
Manho Kim
Sang Kun Lee
Kon Chu
Publikationsdatum
11.09.2017
Verlag
Springer International Publishing
Erschienen in
Journal of NeuroVirology / Ausgabe 6/2017
Print ISSN: 1355-0284
Elektronische ISSN: 1538-2443
DOI
https://doi.org/10.1007/s13365-017-0568-2

Weitere Artikel der Ausgabe 6/2017

Journal of NeuroVirology 6/2017 Zur Ausgabe

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.