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Clinical Oral Investigations

Ausgabe 12/2025

Inhalt (55 Artikel)

Effects of chlorhexidine and a polyherbal mouthwash on the oral microbiome and user satisfaction: a randomized controlled trial

  • Research

Waris Wattanawongwan, Annop Krasaesin, Thutchima Khieota, Vivat Thongchotchat, Thantrira Porntaveetus, Paswach Wiriyakijja

Association between vitamin D supplementation and the prevalence of dental caries and gingivitis in children. A cross-sectional study

  • Open Access
  • Research

Dorota Olczak-Kowalczyk, Marcin Studnicki, Svante Twetman, Anna Turska-Szybka

“Clinical and radiological evaluation of periodontal intrabony defects treated with DFDBA and 1% melatonin gel and its effect on RANKL and OPG in gingival crevicularfluid – a randomized controlled trial”

  • Research

G. Laxmi Kavya, K. Anil Kumar, Gautami S. Penmetsa, Arun Bhupathi, Sruthima NVS Gottumukkala, K. S. V. Ramesh, P. Mohan Kumar, Pavan Kumar Samudrala

Long term dental implant survival and bone level changes with special emphasis on radiation therapy after free fibula flap reconstruction – a retrospective study

  • Open Access
  • Research

Jonas Wüster, Lisa Mahlow, Norbert Neckel, Carsten Rendenbach, Max Heiland, Kirstin Vach, Claudia Sachse, Katja Nelson, Florian Kernen, Susanne Nahles

Necessity of dental restoration before heart valve replacement: a cross-sectional study of a historical cohort

  • Open Access
  • Research

Lucas M. Ritschl, Isabell Bernlochner, Andreas Keßler, Klaus-Dietrich Wolff, Herbert Deppe

Influence of intraoral scan extension on the accuracy of impressions with 3d-printed identical single tooth preparations

  • Open Access
  • Research

Andreas Magnus Geyer, Lara Anabell Gutjahr, Pablo Cores Ziskoven, James Deschner

Aging has occurred rapidly in the facial fracture population – are we ready?

  • Open Access
  • Research

Elias Kultanen, Aleksi Haapanen, Roope Mustasilta, Tero Puolakkainen, Anne Abio, Hanna Thorén, Johanna Snäll

AI-Assisted 3D diagnosis of impacted maxillary canines: A validation study

  • Research

Sara Tinawi, Rodrigo Teixeira, Aron Aliaga-Del Castillo, Erika Benavides, Fabiana Soki, Antonio Carlos De Oliveira Ruellas, Brent Larson, Luis Enersto Arriola Guillén, Yalil Augusto Rodríguez-Cárdenas, Gustavo Armando Ruíz-Mora, Jonas Bianchi, Marcela Gurgel, Felicia Miranda, Dylan Keener, Maxime Gillot, Luc Anchling, Jeanne Claret, Christopher Roberts, Laurie McClatchey McNamara, Mary Barkley, Eric Hannapel, Maria Pinzon, Thomas Gebeck, Nicholas Shirey, Claudia Mattos, Gregory Hummon, Lucia Cevidanes

Long term clinical results of intrabony defects treated with periodontal regeneration. A retrospective analysis based on composite outcome measure

  • Open Access
  • Research

Andrea Blasi, Leopoldo Mauriello, Vincenzo Iorio-Siciliano, Vitolante Pezzella, Gaetano Isola, Luca Ramaglia

Microbial changes in different parts of the oral cavity during the early stage of clear aligner treatment: a preliminary study

  • Research

Yao Jiao, Yan Xu, Yitong Liu, Xiaoyan Li, Xue Li, Siyan Liu, Yi Liu, Yanan Hou, Lijia Guo

Income-related inequalities in the association of obesity and periodontal disease: a register-based cross-sectional analysis in the Tokyo metropolitan districts

  • Open Access
  • Research

Natsumi Saito, Risako Mikami, Koji Mizutani, Norio Aoyama, Takanori Matsuura, Tomonari Suda, Kohei Takeda, Jun Aida, Yuichi Izumi, Takanori Iwata

Preoperative 15 mg of melatonin for surgical discomfort, pain, edema and trismus in mandibular third molar surgery: a randomized double-blind placebo-controlled clinical trial

  • Research

Carolina Ruppel, Helen Heloene Rosa, Renan Bordini Cardoso, Natália Mariane Rigo, Vanessa Carvajal Soto, Marcelo Carlos Bortoluzzi

Cymbopogon citratus essential oil infused zinc oxide nanoparticles for eco-friendly anticariogenic action

  • Research

Preeti Pallavi, Saswat Aryan, Pragnya Paramita Sahoo, Adyasha Anapurba Sahoo, Sangeeta Raut

Sleep disorders, behavioral aspects, general and oral health in children aged 6 to 10 years: structural equation modeling

  • Research

Patrícia Gomes Fonseca, Maria Letícia Ramos-Jorge, Jéssica Madeira Bittencourt, Karina Kendelhy Santos, Maria Eliza da Consolação Soares, Izabella Barbosa Fernandes

Surgical interventions for endodontic-periodontal lesions: A Systematic Review without Meta-analysis (SWiM)

  • Review

Yiyan Yang, Yangqing Peng, Liu Liu, Ziyang Min, Yubin Cao, Dongzhe Song, Dingming Huang

Systemic implications of endodontic and periodontal infections in hematopoietic stem cell transplantation: a systematic review

  • Debate

Maria Emília Mota, Fábio Abreu Alves, Juliana Bertoldi Franco, Jayr Schmidt Filho, Maria Stella Moreira

Salivary parameters and dental caries in normoglycemic and hyperglycemic adults: findings from a cross-sectional analysis

  • Research

Rafaella Cristhina Rego Marques, Joana Rodrigues da Silva, Larisse Santos Mendonça Alves, Bruna Leis Endres, Pedro Chagas Pereira-Neto, Letícia Gonçalves Reis, Carlos Daniel Correa de Oliveira Melo, Eduarda Carvalho Leite, Luana Severo Alves, Naile Dame-Teixeira

Local delivery of hyaluronan and minocycline as an adjunct to subgingival instrumentation in the treatment of stage II grade B diabetic periodontitis: a randomized split-mouth clinical and microbiological study

  • Research

Sally A. ElHaddad, Atef Almokhtar Alasfar, Subhia Ali El-Shaglabow, Enas Ahmed Elgendy, Mohammed N. Zahid, Rotana Marwan Abou-Seedou, Hanadi Ghurmallah Alzahrani

Impact of orthodontic treatment on front teeth with prior history of dental injury: a 4-year follow up

  • Research

Frejlich Alex, Fivez Sofie, Van Gorp Gertrude, Declerck Dominique, Verdonck Anna, Willems Guy, Maria Cadenas de Llano-Pérula

Risk factors and outcomes of consecutive dental implant replacements at failed sites: a retrospective cohort study

  • Research

Ceylan Güzel, Sümer Münevveroğlu, Berk Beşkardeş, Mustafa Temiz

Potential interference of the herpes simplex virus with periodontal regeneration: a narrative review

  • Review

Akira Hasuike, Norihisa Watanabe, Kevin M. Byrd, Akhilanand Chaurasia, Shuichi Sato, Kenichi Imai

Impact of lifestyle behaviors on clinical outcomes of steps 1 and 2 of periodontal therapy in stage iii-iv periodontitis: a cohort study

  • Open Access
  • Research

Federica Romano, Giacomo Baima, Melanie Llerena-Velasquez, Lisa Siccardi, Giacomo Tonello, Marta Vernero, Davide Giuseppe Ribaldone, Mario Aimetti

Genetic and epidemiologic assessment of mandibular cortical indices and bone mineral density in peripubertal children: the Generation R study

  • Open Access
  • Research

Vid Prijatelj, Olja Grgic-Chavez, Justin van der Tas, Constanza L. Andaur Navarro, Andre G. Uitterlinden, Fernando Rivadeneira, Eppo B. Wolvius, Carolina Medina-Gomez

Endodontic surgery using 3D-guides in-house manufacturing and trephine burs for osteotomy and root-end resection: a proof-of‐concept clinical study

  • Open Access
  • Research

Nicola Pranno, Gerardo La Monaca, Gianni Di Giorgio, Alessandro Salucci, Maurizio Bossù, Maria Paola Cristalli

Bioengineered mPCL scaffolds with LiCl-stimulated hPDLCs cell sheets for enhanced periodontal regeneration

  • Research

Pingping Han, Hongxia Dan, Cedryck Vaquette, Andrew Liaw, Yinghong Zhou, Sašo Ivanovski

The association between gingivitis and SARS-CoV-2 colonization of subgingival biofilm in COVID-19 individuals: a cross-sectional preliminary study

  • Research

Tayane da Rocha Costa Coelho, Luciana Machion Shaddox, Guilherme Nunes de Carvalho, Denis Damião Costa, Sara Nunes Vaz, Carlos Brites, Jean Nunes dos Santos, Daniel Araki Araki Ribeiro, Patricia Ramos Cury

Comparative evaluation of ferroptosis markers NCOA4, ACSL4, and Nrf2 in periodontitis with and without type 2 diabetes mellitus: a case-control study

  • Research

Sriram Premkumar, Devapriya Appukuttan, Jaganathan Ranjit Kumar, Santhosh Venkadassalapathy, Sangeetha Subramanian, PSG Prakash, Dhayanand John Victor

ATR-FTIR and confocal microscopy evaluation of irrigation protocols: correlating dentin alteration and biofilm reduction

  • Research

Vanessa Abreu Sanches Marques Costa, Rafaela Fernandes Zancan, Talita Tartari, Carla Regina Albino, Paulo Henrique Weckwerth, Luciano Bachmann, Letycia Accioly Simões Coelho, Murilo Priori Alcalde, Guilherme Ferreira da Silva, Marco Antonio Hungaro Duarte, Rodrigo Ricci Vivan

Vitamin D – a forgotten preventive agent against caries? A narrative review

  • Open Access
  • Review

Julia Grundmann, Susann Hertel, Christian Hannig, Johan P. Woelber

The correlation between body mass index and the effectiveness of non-surgical periodontal treatment in Taiwan population

  • Open Access
  • Research

Kai-Fang Hu, Jwu-Lai Yeh, Ying-Chu Lin, Pei-Feng Liu, Yu-Hsiang Chou, Ching-Jiunn Tseng

Clinical impact of antibiotic resistance in odontogenic infections: a 12-year analysis of 740 cases

  • Open Access
  • Research

Martin Fischer, Jürgen Rödel, Stefan Schultze-Mosgau, Konrad Tolksdorf

Accuracy of deep learning-based AI models for early caries lesion detection: the influence of annotation quality and reference choice

  • Open Access
  • Research

Ricardo E. Gonzalez-Valenzuela, Pascal Mettes, Bruno G. Loos, Henk Marquering, Erwin Berkhout

Drug interaction between non-steroidal anti-inflammatory drugs and warfarin: a cross-sectional study

  • Research

Widla Emanuella Pereira Barreto Garcez, Alex Junio Silva da Cruz, Jennifer Reis-Oliveira, Jacqueline Silva Santos, Maria Auxiliadora Parreiras Martins, Ana Cristina Borges-Oliveira, Mauro Henrique Nogueira Guimarães Abreu

Dynamic biomechanical simulation of long-term tooth movement in clear aligners extraction treatment through iterative macro-micro cycles

  • Research

Xinwei Lyu, Luxian Chen, Huilin Li, Tian Yang, Siyuan Ma, Liping Liu, Cheng Hu, Wei Kuang, Jiali Tan

Exploring confidence in recognizing oral cancer among dentists and dental students

  • Open Access
  • Research

Kamran Ali, Daniel Zahra, Sadeq Ali Al-Maweri, Mahwish Raja

Marginal bone loss in single implant-retained mandibular overdentures using two different healing protocols and two different types of attachments: A 2-year follow-up of a randomized controlled trial

  • Open Access
  • Research

Marwa Abdel Aal, Matthias Kern, Suzy N.Naiem, Iman Abdel wahab Radi, Nouran Abdel Nabi, Amr Ahmed Naguib, Mohamed Sad Chaar

Liquid sodium fluoride versus its hydrogel form for managing postoperative root sensitivity following periodontal flap surgery

  • Research

Vahedeh Sharifi, Ehsan Rafiei, Parisa Ranjbarian, Erfaneh Ghassami, Samin Foroughi Mobarakeh

3D intraoral scanner as an auxiliary tool for the diagnosis of dental hard-tissue conditions

  • Open Access
  • Research

Astrid C. Valdivia Tapia, J. Sebastian Lara, E. Angeles Martinez-Mier, Giovanna C. Denucci, Frank Lippert, George J. Eckert, Anderson T. Hara

Development of a cycling protocol for the in vitro assessment of enamel erosion and the effect of a fluoridated mouthrinse containing micrometric- and nano-sized trimetaphosphate on erosion prevention

  • Research

Jorge Orlando Francisco Cuéllar-Mansilla, Juliano Pelim Pessan, Diego Felipe Mardegan Gonçalves, Marcelle Danelon, Lucas Fernando de Oliveira Tomás Ferraresso, Thayse Yumi Hosida, Caio Sampaio, Alberto Carlos Botazzo Delbem

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  • 11.01.2026
  • EBM
  • Nachrichten

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Was 2026 in Sachen Digitalisierung und Formulare auf Praxen zukommt

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Frau ist im Videocall mit einem Arzt/© seb_ra / Getty Images / iStock (Symbolbild mit Fotomodell), Impfung/© tong2530 / stock.adobe.com (Symbolbild mit Fotomodellen), Arzt tippt an Computer/© Gorodenkoff / Stock.adobe.com (Symbolbild mit Fotomodell)