In our study we analyzed 55 patients treated mainly with definitive or (to a lesser extent) neoadjuvant (chemo)radiation, which are both widely accepted as curative intent treatment options. With this approach we observed a median survival of 12 months with 2-year LC and OS rates of 45 and 26%. These results compare less favorable with large randomized studies including younger populations, which report a median survival of 12–19 months with 2-year LRC rates of 41–57% and 2-year-OS rates of 28–40% using similar definitive chemoradiation schemes [
5,
12,
14,
15]. The SCOPE1 trial recently reported even much more favourable outcomes in their standard arm using definitive chemoradiation leading to a median OS of 25 months with a 2-year OS rate of 56% [
16]. In contrast, a population-based study from the Netherlands including patients from four referral centers treated by radio(chemo)therapy observed very similar results with a median survival of 11 months and 2-year LRC and OS rates of 45 and 22%, respectively [
17], indicating that results generated in the general population may vary distinctly from outcomes in controlled trials. Several other groups have specifically evaluated the outcome of elderly patients with esophageal cancer treated with chemoradiation. They observed median OS times of 13–19 months and 2-year OS rates of 27–43% in more or less selected patient cohorts [
18‐
24]. Servagi-Vernat et al. [
24] performed the only prospective phase II trial and found a 3-year OS of 22% in patients aged ≥75 years treated with chemoradiation consisting of 50 Gy and single-agent cisplatin or oxaliplatin, respectively. Vlacich et al. [
25] reported a national cancer database (NCDB) analysis focusing on treatment utilization and outcome in patients aged ≥70 years and reported a 2-year OS rate of roughly 35% for patients treated by chemoradiation. Regarding the influence of age per se, conflicting results have been described in series directly comparing elderly patients with younger ones. For example, Vonken et al. [
26] compared 76 patients aged ≥70 yrs. with 176 patients aged < 70 years treated either by neoadjuvant or definitive chemoradiation and found no significant difference in overall survival. In contrast, Takeuchi et al. [
20] reported on 33 patients aged > 71 years and 145 patients aged < 70 years treated with definitive chemoradiation and observed a clearly inferior median survival in the elderly group (median OS 14.7 vs 35.1 months). Interestingly, both series reported lower treatment compliance (more chemotherapy dose reductions and/or discontinuations) and Takeuchi et al. [
20] found an increased toxicity in the elderly group. We also observed considerable toxicity in our series including treatment-related deaths in 7 patients, which mainly occurred after patients had been discharged from hospital after treatment was finished. Overall survival and grade 5 toxicities were significantly associated with a Charlson score > 1, indicating that comorbidity may play a more important role than age per se. Tougeron et al. [
22] similarly described a significant association of comorbidity with treatment tolerance and overall survival in their series of 109 patients aged ≥70 treated with definitive chemoradiation. In the prior mentioned NCDB analysis, only 5% of the patients had a Charlson score > 1 compared to 27% in our study, which may have contributed to the favourable results [
25]. Similarly, in the SCOPE1 trial only 15% of the patients included received definitive chemoradiation due to comorbidities and all had good performance status [
16]. Regarding specific comorbidities we did not observe a significant correlation to outcome or grade 5 toxicity, although patients with grade 5 toxicity showed more often cardiovascular comorbidities (57% vs 38%, data not shown). Interestingly, we found large differences in overall outcome and toxicity if patients were stratified according to treatment period. Patient who received treatment after 2008 had a clearly improved outcome with a 1-year LRC and OS rates of 67 and 66% compared to 42 and 24% if treatment started before 2008. Moreover, grade 5 toxicity dropped from 24 to 3%. Comparing the subgroups according to treatment period we observed significantly less advanced T stages (T4 10% vs. 32%) and adenocarcinomas (10% vs. 44%), a significantly increased percentage of patients staged with PET-CT (100% vs. 25%) and a significantly reduced craniocaudal extension of the PTV in recently treated patients. Trends were also observed for the increasing use of IMRT and a lower Charlson score. High T stage is well known to be associated with decreased survival as shown by others [
18,
27,
28] and was also identified as a negative prognostic for OS in our series according to multivariate analysis. Regarding histology, a clear impact on overall survival as not been established so far. While a recent population-based analysis [
17] found a significantly decreased 2-year survival in patients with adenocarcinoma compared to SCC (17% vs 29%) after definitive CRT or RT, a large retrospective cohort analysis for patient treated with chemoradiation could only confirm an increased risk for distant metastases but did not observe a difference in overall survival [
29]. Charlson score has also been shown to be associated with overall survival as well as with grade 5 toxicity in our series. Similarly, Tougeron et al. [
22] observed a significant impact of Charlson score on treatment tolerance, high grade adverse effects and overall survival in their series of elderly patient treated with chemoradiation. Taken together, it seems that a better selection of patients has contributed to the clearly improved outcome in the latter time period. This selection process may have been supported by the increased utilization of PET-CT for staging prior to treatment initiation (100% vs. 25%), which was associated with improved survival in our series according to univariate analysis although not confirmed in multivariate analysis. Similarly, Metzger et al. [
30] recently described an association of PET-CT use with improved local-recurrence free survival and overall survival in their series of 145 patients treated with definitive or neoadjuvant chemoradiation. Treatment-related parameters like modern radiation techniques (IMRT), smaller field length and a more structured follow-up strategy may also have contributed to improved outcome and reduced high grade toxicity in the recently treated patients, although we could not confirm a significant impact of one of those factors independently in our analysis. However, several groups have shown not only dosimetric advantages but also reduced toxicity and sometimes even improved locoregional control and survival with IMRT compared to 3D—conformal approaches [
31‐
33]. A reduction of field length in terms of “involved field irradiation (IFI)” instead of “elective nodal irradiation (ENI)” has been a matter a debate for nearly a decade because of its suggested reduction in toxicity. A recent meta-analysis confirmed a significant reduction of toxicity and observed no significant differences in local control or survival with reduced target volumes [
34]. Moreover, Jing et al. [
35] observed a reduction in toxicity but no difference in OS comparing IFI with ENI in a cohort of patients aged ≥70 years and concluded that IFI should be preferred especially in elderly patients. Taken together, our clearly superior results in the latter time period seemed to be based on a combination of improved patient selection and an adaption of treatment towards less toxic approaches. Interestingly, an indirect comparison of more recent and older prospective trials in unselected patients leads to a similar direction. For example the standard arm of the SCOPE1 trial (started in 2008) reported much better median OS (25 months) and 2-year OS (56%) compared to the standard arm of RTOG 8501 (recruiting patients in the late 80s) with a median OS 12.5 months and a 2-year OS of 38%, although the chemoradiation regimen used in both arms was similar at least regarding radiation dose and chemotherapy drugs [
12,
16]. We also observed a nearby doubled median overall survival comparing our patients from the recent and the previous time period indicating that probably a combination of several advances including patient selection, radiation technique, field design and supportive care may have contributed to the improvement over time. With respect to those boundaries, similar results can be achieved in elderly patients regarding toxicity and outcome compared to unselected cohorts as shown by the results in our recently treated patient group.
Of course our study has some limitations, namely its retrospective nature, small sample size, short follow-up and inhomogeneous patient and treatment characteristics. However, in the absence of randomized trials specifically addressing the value of chemoradiation in elderly patient cohorts we feel that it adds valuable information to the existing body of literature.