Ausgabe 11/2018
Inhalt (11 Artikel)
Clinical Pharmacokinetics and Pharmacodynamics of Dalcetrapib
Donald M. Black, Darren Bentley, Sunny Chapel, Jongtae Lee, Emily Briggs, Therese Heinonen
Drug–Drug Interaction Profile of the Fixed-Dose Combination Tablet Regimen Ledipasvir/Sofosbuvir
Polina German, Anita Mathias, Diana M. Brainard, Brian P. Kearney
Two Decades-Long Journey from Riluzole to Edaravone: Revisiting the Clinical Pharmacokinetics of the Only Two Amyotrophic Lateral Sclerosis Therapeutics
Ranjeet Prasad Dash, R. Jayachandra Babu, Nuggehally R. Srinivas
Valganciclovir Pharmacokinetics in Patients Receiving Oral Prophylaxis Following Kidney Transplantation and Model-Based Predictions of Optimal Dosing Regimens
Thomas Tängdén, Pier Giorgio Cojutti, Jason A. Roberts, Federico Pea
Population Pharmacokinetics of Paritaprevir, Ombitasvir, Dasabuvir, Ritonavir, and Ribavirin in Hepatitis C Virus-Infected Cirrhotic and Non-cirrhotic Patients: Analyses Across Nine Phase III Studies
Sathej Gopalakrishnan, Sven Mensing, Rajeev M. Menon, Jiuhong Zha
A Mechanism-Based Population Pharmacokinetic Analysis Assessing the Feasibility of Efavirenz Dose Reduction to 400 mg in Pregnant Women
Stein Schalkwijk, Rob ter Heine, Angela C. Colbers, Alwin D. R. Huitema, Paolo Denti, Kelly E. Dooley, Edmund Capparelli, Brookie M. Best, Tim R. Cressey, Rick Greupink, Frans G. M. Russel, Mark Mirochnick, David M. Burger
Target-Controlled Continuous Infusion for Antibiotic Dosing: Proof-of-Principle in an In-silico Vancomycin Trial in Intensive Care Unit Patients
Pieter J. Colin, Stijn Jonckheere, Michel M. R. F. Struys
Pharmacokinetics and Safety of Velpatasvir and Sofosbuvir/Velpatasvir in Subjects with Hepatic Impairment
Erik Mogalian, Diana M. Brainard, Anu Osinusi, Lisa Moorehead, Bernard Murray, Kah Hiing John Ling, Robert Perry, Craig Curtis, Eric Lawitz, Kenneth Lasseter, Thomas Marbury, Anita Mathias
A Limited Sampling Strategy to Estimate Exposure of Everolimus in Whole Blood and Peripheral Blood Mononuclear Cells in Renal Transplant Recipients Using Population Pharmacokinetic Modeling and Bayesian Estimators
Ida Robertsen, Jean Debord, Anders Åsberg, Pierre Marquet, Jean-Baptiste Woillard
Comment on “Effect of Age-Related Factors on the Pharmacokinetics of Lamotrigine and Potential Implications for Maintenance Dose Optimisation in Future Clinical Trials”
Joseph F. Standing, Brian J. Anderson, Stefanie Hennig, Nick H. Holford, Trevor N. Johnston, Catherijne A. J. Knibbe, Dagan O. Lonsdale, Amin Rostami-Hodjegan
Authors’ Reply to Standing et al.: “Effect of Age-Related Factors on the Pharmacokinetics of Lamotrigine and Potential Implications for Maintenance Dose Optimisation in Future Clinical Trials”
Sven C. van Dijkman, Nico C. B. de Jager, Willem M. Rauwé, Meindert Danhof, Oscar Della Pasqua