Ausgabe 2/2015
Inhalt (7 Artikel)
Open Access
Review Article
Clinical and Preclinical Pharmacokinetics and Pharmacodynamics of Mipomersen (Kynamro®): A Second-Generation Antisense Oligonucleotide Inhibitor of Apolipoprotein B
Richard S. Geary, Brenda F. Baker, Stanley T. Crooke
Review Article
Clinical Pharmacokinetics and Pharmacodynamics of Clopidogrel
Xi-Ling Jiang, Snehal Samant, Lawrence J. Lesko, Stephan Schmidt
Original Research Article
Tramadol and O-Desmethyl Tramadol Clearance Maturation and Disposition in Humans: A Pooled Pharmacokinetic Study
Karel Allegaert, Nick Holford, Brian J. Anderson, Sam Holford, Frank Stuber, Alain Rochette, Iñaki F. Trocóniz, Horst Beier, Jan N. de Hoon, Rasmus S. Pedersen, Ulrike Stamer
Original Research Article
Prediction of Drug Disposition in Diabetic Patients by Means of a Physiologically Based Pharmacokinetic Model
Jia Li, Hai-fang Guo, Can Liu, Zeyu Zhong, Li Liu, Xiao-dong Liu
Open Access
Original Research Article
A Prospective Population Pharmacokinetic Analysis of Sapropterin Dihydrochloride in Infants and Young Children with Phenylketonuria
Yulan Qi, Diane R. Mould, Huiyu Zhou, Markus Merilainen, Donald G. Musson
Original Research Article
Population Pharmacokinetic Model of THC Integrates Oral, Intravenous, and Pulmonary Dosing and Characterizes Short- and Long-term Pharmacokinetics
Jules A. A. C. Heuberger, Zheng Guan, Olubukayo-Opeyemi Oyetayo, Linda Klumpers, Paul D. Morrison, Tim L. Beumer, Joop M. A. van Gerven, Adam F. Cohen, Jan Freijer