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Clinical Pharmacokinetics

Ausgabe 3/2025

Inhalt (12 Artikel)

Pharmacokinetics of Opioid Infusions in the Adult Intensive Care Unit Setting—A Systematic Review

  • Systematic Review

Johannie Beaucage-Charron, Justine Rinfret, Guillaume Trottier, Marie-Maxim Sévigny, Lisa Burry, Amélie Marsot, David Williamson

Solubility-Limited Absorption Identified by a Simplified PBPK Model for the Prediction of Positive Food Effect for BCS II/IV Drugs

  • Commentary

Karine Rodriguez-Fernandez, José David Gómez-Mantilla, Suneet Shukla, Victor Mangas-Sanjuán, Sheila Annie Peters

Evaluation of Solubility-Limited Absorption as a Surrogate to Predicting Positive Food Effect of BCS II/IV Drugs

  • Open Access
  • Original Research Article

Karine Rodriguez-Fernandez, José David Gómez-Mantilla, Suneet Shukla, Peter Stopfer, Peter Sieger, Victor Mangas-Sanjuán, Sheila Annie Peters

Exposure to Rifampicin and its Metabolite 25-Deacetylrifampicin Rapidly Decreases During Tuberculosis Therapy

  • Open Access
  • Original Research Article

Sylvain Goutelle, Olivier Bahuaud, Charlotte Genestet, Aurélien Millet, François Parant, Oana Dumitrescu, Florence Ader, F. Ader, O. Bahuaud, R. Bayaa, A. Becker, E. Braun, P. Chabert, P. Chauvelot, C. Chedid, A. Conrad, O. Dumitrescu, T. Ferry, C. Genestet, S. Goutelle, E. Hodille, J. Hoffmann, C. Javaux, G. Lina, C. Pouderoux, T. Perpoint, S. Roux, M. Simon, F. Valour

Effect of Hepatic Impairment or Renal Impairment on the Pharmacokinetics of Aficamten

  • Open Access
  • Original Research Article

Donghong Xu, Justin D. Lutz, Punag Divanji, Jianlin Li, Youcef Benattia, Adrienne Griffith, Stephen B. Heitner, Stuart Kupfer, Polina German

Clinical Pharmacokinetics of Oral ALZ-801/Valiltramiprosate in a 2-Year Phase 2 Trial of APOE4 Carriers with Early Alzheimer’s Disease

  • Open Access
  • ORIGINAL ARTICLE

John A. Hey, Jeremy Y. Yu, Susan Abushakra, Jean F. Schaefer, Aidan Power, Pat Kesslak, Jijo Paul, Martin Tolar

Population Pharmacokinetics of Cobicistat and its Effect on the Pharmacokinetics of the Anticancer Drug Olaparib

  • Open Access
  • Original Research Article

Joanneke K. Overbeek, Nielka P. van Erp, David M. Burger, Alfons A. den Broeder, Stijn L. W. Koolen, Alwin D. R. Huitema, Rob ter Heine

Clinical Exploration and Physiologically Based Modelling of the Impact of Hepatic Impairment on Entrectinib Pharmacokinetics

  • Original Research Article

Agustos C. Ozbey, Georgina Meneses-Lorente, Brian Simmons, Sam McCallum, Pieter Annaert, Neil Parrott, Kenichi Umehara

Plasma Concentrations of Direct Oral Anticoagulants in Patients with Nonvalvular Atrial Fibrillation and Different Degrees of Obesity

  • Open Access
  • Original Research Article

Danilo Menichelli, Arianna Pannunzio, Erminia Baldacci, Vittoria Cammisotto, Valentina Castellani, Rosaria Mormile, Ilaria Maria Palumbo, Antonio Chistolini, Francesco Violi, Job Harenberg, Daniele Pastori, Pasquale Pignatelli

Correction: Clinical Pharmacokinetics of Psilocin After Psilocybin Administration: A Systematic Review and Post‑Hoc Analysis

  • Open Access
  • Correction

Marije E. Otto, Katelijne V. van der Heijden, Jan W. Schoones, Michiel J. van Esdonk, Laura G. J. M. Borghans, Gabriel E. Jacobs, J. G. Coen van Hasselt