Ausgabe 4/2018
Inhalt (9 Artikel)
Key Pharmacokinetic Essentials of Fixed-Dosed Combination Products: Case Studies and Perspectives
Ranjeet Prasad Dash, Rana Rais, Nuggehally R. Srinivas
PARP Inhibitors in the Treatment of Triple-Negative Breast Cancer
Jill J. J. Geenen, Sabine C. Linn, Jos H. Beijnen, Jan H. M. Schellens
Antibiotic Distribution into Cerebrospinal Fluid: Can Dosing Safely Account for Drug and Disease Factors in the Treatment of Ventriculostomy-Associated Infections?
Nilesh Kumta, Jason A. Roberts, Jeffrey Lipman, Menino Osbert Cotta
Clinical Pharmacokinetics and Pharmacodynamics of the Epidermal Growth Factor Receptor Inhibitor Panitumumab in the Treatment of Colorectal Cancer
Sander Ketzer, Kirsten Schimmel, Miriam Koopman, Henk-Jan Guchelaar
A Population Pharmacokinetic Model to Predict the Individual Starting Dose of Tacrolimus Following Pediatric Renal Transplantation
Louise M. Andrews, Dennis A. Hesselink, Teun van Gelder, Birgit C. P. Koch, Elisabeth A. M. Cornelissen, Roger J. M. Brüggemann, Ron H. N. van Schaik, Saskia N. de Wildt, Karlien Cransberg, Brenda C. M. de Winter
Explaining Ethnic Variability of Transporter Substrate Pharmacokinetics in Healthy Asian and Caucasian Subjects with Allele Frequencies of OATP1B1 and BCRP: A Mechanistic Modeling Analysis
Rui Li, Hugh A. Barton
Prediction of the Effect of Renal Impairment on the Pharmacokinetics of New Drugs
Elisa Borella, Italo Poggesi, Paolo Magni
Predicting Cortisol Exposure from Paediatric Hydrocortisone Formulation Using a Semi-Mechanistic Pharmacokinetic Model Established in Healthy Adults
Johanna Melin, Zinnia P. Parra-Guillen, Niklas Hartung, Wilhelm Huisinga, Richard J. Ross, Martin J. Whitaker, Charlotte Kloft
Influence of Disease and Patient Characteristics on Daratumumab Exposure and Clinical Outcomes in Relapsed or Refractory Multiple Myeloma
Xiaoyu Yan, Pamela L. Clemens, Thomas Puchalski, Sagar Lonial, Henk Lokhorst, Peter M. Voorhees, Saad Usmani, Paul G. Richardson, Torben Plesner, Kevin Liu, Robert Z. Orlowski, Nedjad Losic, Richard Jansson, Tahamtan Ahmadi, Kristen Lantz, Juan Jose Perez Ruixo, Honghui Zhou, Xu Steven Xu