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Clinical Pharmacokinetics

Clinical Pharmacokinetics OnlineFirst articles

13.02.2019 | Review Article Open Access

Pharmacology, Pharmacokinetics and Pharmacodynamics of Eculizumab, and Possibilities for an Individualized Approach to Eculizumab

Eculizumab is the first drug approved for the treatment of complement-mediated diseases, and current dosage schedules result in large interindividual drug concentrations. This review provides insight into the pharmacokinetic and pharmacodynamic …

07.02.2019 | Review Article Open Access

Physiologically Based Pharmacokinetic Modelling for First-In-Human Predictions: An Updated Model Building Strategy Illustrated with Challenging Industry Case Studies

Physiologically based pharmacokinetic modelling is well established in the pharmaceutical industry and is accepted by regulatory agencies for the prediction of drug–drug interactions. However, physiologically based pharmacokinetic modelling is …

28.01.2019 | Review Article Open Access

Voriconazole: A Review of Population Pharmacokinetic Analyses

Numerous population pharmacokinetic studies on voriconazole have been conducted in recent years. This review aimed to comprehensively summarize the population pharmacokinetic models for voriconazole and to determine which covariates have been …

24.01.2019 | Original Research article

Physiologically Based Pharmacokinetic Modelling of Hyperforin to Predict Drug Interactions with St John’s Wort

St John’s wort (SJW; Hypericum perforatum L.) is the most frequently used herbal medicine for treatment of depression throughout the world [ 1 ]. A Cochrane systematic review deduced that SJW was superior to placebo with response rate ratio of 1.28 …

23.01.2019 | Original Research Article Open Access

Personalized Tuberculosis Treatment Through Model-Informed Dosing of Rifampicin

In 2016, the global incidence of tuberculosis (TB) was estimated at 10.4 million and it remains one of the most common causes of death worldwide, with approximately 1.7 million fatalities annually [ 1 ]. The treatment success rate for new and …

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Clinical Pharmacokinetics is the major review journal in the area of clinical pharmacokinetics, the study of drug disposition in the human body, which is an integral part of drug development and rational use.

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