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Clinical Pharmacokinetics


Clinical Pharmacokinetics OnlineFirst articles

10.08.2022 | Original Research Article

Prediction of Tissue Exposures of Meropenem, Colistin, and Sulbactam in Pediatrics Using Physiologically Based Pharmacokinetic Modeling

Overuse of antibiotics worldwide has led to the emergence of multidrug-resistant (MDR) bacteria. Many antibiotics in monotherapy use are no longer efficacious against MDR bacteria [ 1 ]. This problem has led to a renewed interest in colistin and …

Open Access 06.08.2022 | Original Research Article

Evaluation of Safety and Clinically Relevant Drug–Drug Interactions with Tucatinib in Healthy Volunteers

Human epidermal growth factor receptor 2 (HER2) gene overexpression or amplification is an oncogenic driver in various cancers, with multiple therapies having been developed to target HER2 [ 1 ]. However, despite the increased survival offered by …

30.07.2022 | Commentary

Up to 100 g of Intravenous Vitamin C Appears to be Safe and Elicits No Adverse Effects but Needs Further Evaluation in High-Risk Groups

In a recent issue of Clinical Pharmacokinetics , Chen et al. evaluated the pharmacokinetics of intravenous vitamin C (IVC) in a population of 21 healthy volunteers and 12 oncology patients [ 1 ]. The exclusion criteria involved patients with a …

Open Access 30.07.2022 | Original Research Article

Single-Dose Pharmacokinetics of Milvexian in Participants with Normal Renal Function and Participants with Moderate or Severe Renal Impairment

Patients with cardiovascular and thromboembolic diseases are at an increased risk of serious thrombotic events, which necessitates the use of antithrombotic therapies [ 1 – 5 ]. However, fears about an increased risk of bleeding events can lead to …

27.07.2022 | Research Letter

Influence of Darolutamide on Cabazitaxel Systemic Exposure

Über diese Zeitschrift

Clinical Pharmacokinetics is the major review journal in the area of clinical pharmacokinetics, the study of drug disposition in the human body, which is an integral part of drug development and rational use.

Clinical Pharmacokinetics
Volume 32/1997 - Volume 61/2022
Springer International Publishing
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