Discussion
The SnapAppy analysis of the current state of acute appendicitis management offers valuable insights regarding practice patterns and outcomes across widely disparate health systems and settings. Besides affording comparisons between different countries, these data allow us to explore how current practice interfaces with existing evidence regarding that care. To that end, we have compared observational data with two major guidelines—that of the World Society of Emergency Surgery for the management of patients with acute appendicitis and that of the Surviving Sepsis Campaign for the management of patients with sepsis or septic shock (Table
1) [
30,
31]. While the SSC guidelines may be viewed as primarily appropriate for medical disease, or postoperative infection such as pneumonia, recent iterations of the guidelines also highlight the importance of source control for patients with a source controllable lesion [
30]. Therefore, appendectomy for acute appendicitis provides an ideal opportunity to achieve rapid and effective source control in the absence of perforation.
Guidelines provide an evidence base upon which clinicians may rely to inform care decisions [
41]. Often, guidelines are generated using a modified Delphi consensus approach that yields recommendations, suggestions, best practices, and the recognition that data are sufficiently lacking for some topics to preclude guidance [
22,
23]. Some guidelines, but not all, are accompanied by a ‘bundle’ that provides an implementation strategy that translates to the bedside [
41]. When there is no offered implementation strategy, the individual clinician, group, or facility must devise how best to incorporate the evidence base into their practice. Unsurprisingly, the completeness with which evidence is embraced within practice is often less than uniform, creating what has been termed an ‘evidence-to-practice’ gap [
42]. The abrogation of such gaps across all disciplines is a key priority of the expanding field of implementation science. The evidence-to-practice gap bears important implications for care quality, safety, and cost, rendering it imperative to understand what supports the creation of the gap.
Established drivers of the evidence-to-practice gap include individual, environment, and system factors. Established practice is generally comfortable for the clinician, and inertia may impede change. The notion that trial patients from whom the data are derived are different from those the clinician treats has some validity, especially when the data flow from Randomized Clinical Trials with restrictive entry criteria. However, a host of other assessments, like this study, is not restricted and provides evidence that may be broadly applied. Other clinician factors include a lack of awareness of newly published evidence, especially if the data are published behind a pay wall. Guidelines, on the other hand, are often freely accessible, even if only as an executive summary. Additional impediments are those related to the environment of care and the healthcare system. The lack of an electronic health record (EHR), as is the case in many of our contributing centers, may confound obtaining longitudinal data for assessment. Practice within a resource limited space, including those within low- and middle-income countries (LMIC), may constrain diagnostic modality availability, as well as therapeutic agent selection. Patients operated after 24 h may reflect lack of OR availability in resource constrained settings, a constraint that would not be remedied by an Emergency General Surgery service—an initiative that durably decreased time to OR for time sensitive conditions [
43,
44]. Clinician availability may reduce the oversight required for timely termination of perioperative antibiotics, in the absence of an established pathway, or advanced practice provider (APP) to help guide care. These aspects likely contributed to the low frequency of an enhanced recovery after surgery (ERAS) approach that includes same day discharge for uncomplicated appendicitis in otherwise healthy adults [
45,
46].
Nonetheless, our data demonstrate that practice can conform to guideline-based recommendations—which suggests the lack of an evidence-to-practice gap—across very different healthcare systems (USA, Estonia, Romania), at least in participating centers. Despite the ability to embrace guideline recommendations in select sites, most centers demonstrated failures in guideline adoption. These failures were most notable in antibiotic cessation timing and inpatient care (time to operation, and the lack of outpatient care for uncomplicated appendicitis). While not readily apparent on an individual patient basis, collectively, these choices exert major impacts on cost and serve as a driving force for the genesis of multidrug-resistant organisms [
47‐
49]. Individual clinician management approaches influence microbial ecology within the hospital and the community, including chronic care facilities. Accordingly, antimicrobial stewardship programs (ASPs) have arisen to help guide appropriate antibiotic selection and cessation. ASPs bring additional clinicians onto the team to support embracing new evidence and incorporating it into practice but are insufficient in isolation. Other approaches are warranted to systematically close the gap.
A variety of methods may help close the evidence-to-practice gap and are presented below in order of increasing difficulty but also increasing anticipated efficacy. Clinician education is straightforward and may use a variety of platforms from traditional didactics to ‘just-in-time’ digital platform-based training. Despite the ease of providing education, it is challenging to demonstrate robust practice change in its wake [
50‐
52]. Providing an incentive to change practice is more appealing, especially when financially based, but requires institutional resources or insurer resources to realize; incentives may be especially problematic in resource limited spaces. Exacting a penalty for compliance failure may be effective but then requires data reporting, analysis, and a larger system to ensure accurate attribution and penalty application. This is especially true when the penalty is related to finances that flow to an individual clinician as opposed to an established institution. Public reporting of compliance and outcomes may be built as an outgrowth of data acquisition and works best when it is mandated by a state or national agency. Such is the case for the New York State Department of Health’s mandatory reporting around sepsis care. There is substantial pressure for institutional performance when it is documented as lagging behind that of other institutions or practitioners. Finally, establishing a local champion who can access clinician specific data, review it with them, and provide peer-to-peer education and feedback holds the potential to be quite effective [
53‐
55]. However, that individual must be credible, have sufficient time to do so, be compensated for time and effort, and work within a medical staff that is willing to have their practice examined by a peer. In the private sector, that peer may also compete for the same patients, relegating such ‘counselling’ to teaching institutions where such competition is less applicable. When such a system is feasible, the peer reviewer functions as a team member for the clinician, a post that may be particularly important for those in solitary practice.
Our observational study of acute appendicitis management offers a view of current practice while also demonstrating important limitations. First, due to time-bound simultaneous patient accrual, our data do not capture outcomes beyond 90 days after admission. Second, the original intention of the 90-day follow-up informed by anecdotal experience during the early phase of the COVID-19 pandemic was to capture early readmission with recrudescent appendicitis due to failure of nonoperative antibiotic therapy. However, very few patients undergoing nonoperative therapy were captured in our dataset. This is at least in part be explained using operating room logs to identify enrollable patients at centers without an EHR. Third, granular elements of patient care were not captured including, but not limited to, anesthetic technique, culture data, and specific antibiotic prescription. However, those elements were not the focus of the study. Furthermore, due to the heterogeneity on a national level, socioeconomic status, race/ethnicity, and insurance status were not recorded. Fourth, the correlations presented are merely associative and should not be construed as indicating causation, especially regarding complications that were quite infrequent. Prospective correlative analysis of outcomes would require a population-level epidemiologic study. Fifth, we did not assess all the bundle elements from the SSC as that inquiry would require a granularity that exceeded the scope of this investigation. Finally, as these data were limited to adult patients admitted for appendicitis, they should not be extrapolated to the pediatric population.
Acknowledgements
European Society of Trauma and Emergency Surgery (ESTES) SnapAppy Group. Manuscript Writing Group: Gary Alan Bass, Shahin Mohseni, Éanna J Ryan, Maximilian Peter Forssten, Matti Tolonen, Yang Cao, Lewis J Kaplan. SnapAppy Steering Committee: Division of Traumatology, Surgical Critical Care & Emergency Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA: Gary Alan Bass, Lewis J. Kaplan; Division of Trauma & Emergency Surgery, Orebro University Hospital and School of Medical Sciences, Orebro University, Sweden: Shahin Mohseni (Co-Chair), Maximilian Peter Forssten, Arvid Pourlotfi, Éanna J. Ryan; Center for Perioperative Outcomes Research and Transformation (CPORT), University of Pennsylvania, Philadelphia, USA: Gary Alan Bass; Leonard Davis Institute of Health Economics (LDI), University of Pennsylvania, Philadelphia, USA: Gary Alan Bass; Tallaght University Hospital, Dublin, Ireland: Éanna J. Ryan; Hospital Universitario Juan Ramón Jiménez de Huelva, Huelva, Spain: Isidro Martinez-Casas; Department of General Surgery, Trieste University Hospital, Trieste, Italy: Alan Biloslavo; Centro Hospitalar Tondela, Viseu, Portugal: Jorge Pereira; Helsinki University Hospital HUS Meilahden Tornisairaala, Helsinki, Finland: Matti Tolonen; Department of Surgery, Karolinska Instituet, Stockholm, Sweden: Rebecka Ahl Hulme; Humanitas Clinical and Research Center, IRCCS, Milano, Italy: Hayato Kurihara; Clinical Epidemiology and Biostatistics, School of Medical Sciences, Orebro University, Orebro, Sweden: Yang Cao; Corporal Michael Crescenz Veterans Affairs Medical Center, Philadelphia, USA: Lewis J. Kaplan. Contributing Centers and Authors: Bahrain Defence Force-Royal Medical Services, Bahrain: Nayef Louri, Fatema Nedham, Thomas Noel Walsh, Jamal Hashem; King Hamad University Hospital, Bahrain: Martin Corbally, Abeer Farhan, Hamad Al Hamad, Rawan Elhennawy; Salmaniya Medical Complex, Bahrain: Mariam AlKooheji, Manar AlYusuf, Wissal Aknouche, Anas A. Zeidan, Yusuf S. Alsaffar; North Estonia Medical Center, Estonia: Edgar Lipping, Peep Talving, Sten Saar, Katrina Graumann, Liis Kibuspuu, Eduard Harkov; HUS Meilahden Tornisairaala, Finland: Gisele Aaltonen, Iines S. Sillman, Sami Haapanen; HUS Jorvin sairaala, Finland: Hanna Lampela, Henna Sammalkorpi, Sofia Eskola, Altti Laakso; Hyvinkää Hospital Area, Finland: Johan Back, Ulla Kettunen, Antti M. Nummi, Anika Szwedyc, Taina Nykänen, Rolle Rantala; Oulun Yliopistollinen Sairaala, Finland: Elisa J. Mäkäräinen-Uhlbäck, Sanna A. Meriläinen, Heikki I. Huhta, Jukka M. J. Rintala, Kirsi E. M. Laitakari; Turku University Hospital, Finland: Elina Lietzen, Paulina Salminen, Risto K. A. Rapola; Namazi Hospital, Shiraz University of Medical Sciences, Iran: Vahid Zangouri, Mohammad Y. Karami, Sedigheh Tahmasebi, Majid Akrami, Alireza Golchini, Faranak Bahrami; Tullamore General Hospital, Ireland: Sean M. Johnston, Sean T. Lim, Irele Ifijeh Ahonkhai, Eltahir Eltagani, Odhran K. Ryan; St Vincent's University Hospital , Ireland: Ailbhe O’Driscoll-Collins, Aine O'Neill , Zakiya Penny, Orlaith Kelly, Carolyn Cullinane, Ian Reynolds, Helen Heneghan, Sean Martin, Des Winter; Galway University Hospitals, Ireland: Matthew Davey, Maha Alkhattab, Aoife J. Lowery, Michael J. Kerin, Aisling M. Hogan, Martin S. Davey, Ke En Oh; Letterkenny University Hospital, Ireland: Syed Mohammad Umar Kabir, Huilun Huan, Charlotte Aziz, Michael Sugrue; University Hospital Waterford, Ireland: Jessica M. Ryan, Tara M. Connelly, Mohammad Alhazmi, Youssef Al-Mukhaizeem, Fiachra Cooke, Peter M. Neary; Beaumont Hospital, Ireland: Arnold D. K. Hill, Michael R. Boland, Angus J. Lloyd, Frances Fallon, Eoin F. Cleere, James Toale; Mayo University Hospital, Ireland: Patrick A. Boland, Michael Devine, Conor Keady, Sarah Hunter, M. Kevin Barry; Tallaght University Hospital, Ireland: Michael E. Kelly, Aidan T. O'Dowling, Ben Creavin, Dara O. Kavanagh, Paul Neary, Paul F. Ridgway, Cathleen A. McCarrick; St James' University Hospital, Ireland: Jarlath Bolger, Barry Maguire, Cian Keogh, Surbhi Chawla; Mater Misericordiae University Hospital, Ireland: John Conneely, Emilie McCormack , Ben Shanahan, Nicola Raftery, Darragh Rice, Niall McInerney, Aine Stakelum, Jan Mares, Jonavan Tan, Mark Hanna, Ishwarya Balasubramanian, Christina Fleming; Soroka University Medical Center, Israel: Guy Barsky, Gad Shaked; Emergency Surgery and Trauma Section, Humanitas Research Hospital, Rozzano, Italy: Simone Giudici, Martina Ceolin, Simona Mei, Francesca Mazzarella; Trieste University Hospital, Italy: Annalisa Zucca, Susanna Terranova, Nicolo de Manzini; Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Italy: Diego Visconti, Emanuele Doria, Mauro Santarelli; San Maurizio Hospital, Bolzano, Italy: Giovanni Scotton, Francesca Notte, Giacomo Bertelli, Anna Malpaga, Giulia Armatura, Antonio Frena; Cisanello Hospital, University of Pisa, Italy: Dario Tartaglia , Federico Coccolini , Camilla Cremonini , Enrico Cicuttin , Alessio Mazzoni , Massimo Chiarugi; Centro Hospitalar Universitário da Cova da Beira, Portugal: Constança M. Azevedo, Filipa D. Mendes, Luis Q. Faria, Carlos Nazario, Daniela Machado, Miguel Semiao; Centro Hospitalar Tondela-Viseu, Portugal: Jorge Pereira, Carlos Casimiro, Jose Pinto, Tiago Pavão, Raquel Pereira, Bruno Barbosa; Centro Hospitalar de Trás-os-Montes e Alto Douro, Portugal: Nadia Tenreiro, Catia Ferreira, Goncalo Guidi, Daniela C. Martins, Clara Leal, Bruno B. Vieira; North Lisbon University Hospital Center, Portugal: Luís S. Castro, Aldara Faria, Alberto Figueira, Mauro Sousa, Pedro Rodrigues, Rodrigo Roquette; Centro Hospitalar Universitário do Algarve—Hospital de Faro, Portugal: Ricardo Ribeiro, Paulo Cardoso, Joana Domingues, Maria Isabel Manso, Rute Pereira, Tatiana Revez; Ponderas Academic Hospital, Bucharest, Romania: Bogdan D. Dumbrava, Florin Turcu, Ionut Hutopila, Bogdana Banescu, Gerald Filip, Catalin Copaescu; Hospital Universitario Juan Ramón Jiménez, Spain: Marcos Alba Valmorisco, Isabel Manzano Martín, Rocio, José Ortega Seda, Pablo Rodríguez González, Jose Antonio Becerra Toro, Enrique Rodríguez Lara, Jose Antonio González Minchón; Hospital Universitario Son Espases, Spain: Juan José Segura-Sampedro, Sebastián Jerí-McFarlane, Alejandro Gil-Catalán, Andrea Craus-Miguel, Laura Fernández-Vega, Xavier González-Argenté; Hospital General Universitario de Ciudad Real, Spain: Mercedes Estaire-Gómez, Borja Camacho Fernández-Pacheco, Rebeca Vitón-Herrero, Elisa Jimenez-Higuera, Alejandro Barbero, José M. Valverde; Hospital Universitario Son Llàtzer, Spain: Enrique Colás-Ruiz, Maria del Mar Escales-Oliver, Olga Claramonte-Bellmunt, Marta Castro-Suárez, Naila Pagés-Valle, José Andrés Cifuentes-Ródenas; Hospital Universitario Central de Asturias, Spain: Marta Merayo Alvarez, Jose Luis Michi Campos, Luis Alejandro, Beatriz, Jaime, Jose Luis; Infanta Sofía University Hospital , Spain: Carmen Rodríguez Haro, Sara Núñez O'Sullivan, Mariana García Virosta, María Hernández O'Reilly; Hospital Universitario de La Ribera, Spain: Izaskun Balciscueta-Coltell, Javier Lorenzo-Perez, Sonia Martinez-Alcaide, Susana Martinez-Ramos, Maria Sebastian-Fuertes, Laura Gomez-Romer; Hospital Universitario de Gran Canaria Dr Negrín , Spain: Maria M. Pelloni, Aida Cristina Rahy-Martín, Andrés Felipe Yepes-Cano; Hospital Universitario Virgen Macarena , Spain: Julio Reguera-Rosal, Jose A. Lopez-Ruiz, Beatriz Marenco, Marina Retamar-Gentil, Estela Romero-Vargas, Angeles Gil-Olarte; Urduliz Alfredo Espinosa Hospital , Spain: Aitor Landaluce-Olavarria , Begoña Estraviz-Mateos , Jose-Mario De Francisco-Rios, Aitor Sainz-Lete , Ane Emaldi-Abasolo , Manolo Leon-Valarezo; Donostia University Hospital , Spain: Claudia C. Lopes Moreira, Aintzane Lizarazu Perez, Araceli Rodriguez Gonzalez, Iñigo Augusto Ponce, Ignacio Maria Goena Iglesias; Hospital Universitario de Burgos , Spain: Cristina González-Prado , Guillermo Cabriada, Beatriz López, Michelle C Otero, Nerea Muñoz-Plaza, Alberto Palomo; Hospital Universitario Príncipe de Asturias , Spain: Fernando Mendoza-Moreno, Manuel Díez-Alonso, Francisca García-Moreno-Nisa, Belén Matías-García, Enrique Ovejero-Merino, Ana Quiroga-Valcárcel; Elche University General Hospital, Alicante , Spain: Luis Sánchez-Guillén, Inmaculada Oller-Navarro, Álvaro Soler-Silva, Antonio Francisco Sanchís-López; Complejo Asistencial Universitario de Salamanca, Spain: Francisco Blanco-Antona, Luis Muñoz-Bellvis, Jaime López-Sánchez, Sonsoles Garrosa-Muñoz, Beatriz Barón-Salvador, Juan Manuel Nieto-Arranz; Hospital Universitari Parc Taulí , Spain: Andrea Campos-Serra, Raquel Gràcia-Roman, Anna Muñoz-Campaña, Carla Zerpa-Martin, Andrea Torrecilla-Portoles, Tessa Landa; Virgen del Rocío University Hospital, Spain: Virginia Durán Muñoz-Cruzado, Felipe Pareja-Ciuró, Daniel Aparicio-Sánchez, Eduardo Perea del Pozo, Sandra Dios-Barbeito, Carlos García-Sánchez, Antonio Jesús García-Moriana; Hospital Clinic Barcelona , Spain: Victor Turrado-Rodriguez, Roser Termes-Serra, Paula Gonzalez-Atienza, Xavier Morales-Sevillano, Alba Torroella, César Ginestà Hospital Universitario Arnau de Vilanova , Spain: Alfredo Escartín, Ferney Gomez, Ana Pinillos, Jaume Ortega, Guillermo Lopez, Eric Gutierrez; Hospital Del Mar de Barcelona , Spain: Estela Membrilla-Fernandez, Francisco Ocho-Segarra, Ana María González-Castillo, Amalia Pelegrina-Manzano, Juan Guzmán-Ahumada, Juan Jose Sancho-Insenser; Complejo Hospitalario Universitario de A Coruña , Spain: María Lourdes García-Jiménez, Laura Castro-Diez, Manuel González-Bermúdez, Mónica Torres-Díaz, Carla Madarro Pena, Angélica Blanco Rodríguez; Örebro University Hospital, Sweden: Dhanisha Trivedi, Souheil Reda; Capio S:t Göran Hospital, Sweden: Hans Edvardsson, Lovisa Strömmer; Sahlgrenska University Hospital, Sweden: Eva-Corina Caragounis, Karin Sillén, Sofia Warfvinge; Sahlgrenska University Östra Hospital, Sweden: Fredrik Bergstedt, Philip Enström, Harald Olsson, Anders Rosemar; Karolinska University Hospital, Sweden: Nathalie Young, Agnieszka Popowicz, Johanna Lerström, Johanna Jäderbo, Folke Hammarqvist; Danderyds Hospital,
Sweden: Hanna Zacharias; Karlstad Hospital, Sweden: Maria B. Wikström, Anna Stene Hurtsén; Östersund County Hospital, Sweden: Haytham Bayadsi, Emma Jansson, Nils Brunstrom, Ellen B. Malers; Linköping University Hospital, Sweden: Per I. Loftås, Anders Möller, Elena Atanasova; Bern University Hospital, University of Bern, Switzerland: Simone N. Zwicky, Beat Schnüriger; Aintree University Hospital, UK: Olga Rutka, Arjun T. Kattakayam, Mushfique Alam, John V. Taylor; Tameside and Glossop Integrated Care NHSFT, UK: Andrei Mihailescu, Eszter T. Karip, Ehtisham Zeb, Adam O'Connor, Goran Pokusevski; Brighton and Sussex University Hospitals, Brighton, UK: Mansoor Khan, Charlotte Florance, Christie Swaminathan, Shameen Jaunoo, Mohammed Sajid; University of Pennsylvania Hospital System, Philadelphia, USA: Caoimhe C. Duffy, John Rees, Mark J. Seamon, Niels D. Martin, Ian J. McCurry, Emily A. Vail, Bradford C. Bormann; Maine Medical Center, USA: Daniel C. Cullinane, Jaswin S. Sawhney, Jonathan Dreifus, Forest R. Sheppard; Riverside University Health System Medical Center, USA: Raul Coimbra, Paul Albini, Sara Edwards.