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Erschienen in: Digestive Diseases and Sciences 10/2019

13.04.2019 | Original Article

Clinical Predictors of Rapid Gastric Emptying in Patients Presenting with Dyspeptic Symptoms

verfasst von: Juan Gomez Cifuentes, Mark Radetic, Rocio Lopez, Scott Gabbard

Erschienen in: Digestive Diseases and Sciences | Ausgabe 10/2019

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Abstract

Background

Rapid gastric emptying (RGE) is defined as less than 30% retention at 1 h of solid meal ingestion. It is unclear whether RGE represents a separated clinical entity or part of the functional dyspepsia spectrum.

Aims

To determine clinical predictors of RGE in patients presenting with dyspeptic symptoms.

Methods

Retrospective study of patients who underwent solid Gastric Emptying Scintigraphy to evaluate dyspeptic symptoms from January 2011 to September 2012. Patients with delayed gastric emptying (> 10% gastric retention at 4 h) or prior gastric surgery were excluded. Patients with RGE were compared to those with normal gastric emptying (NGE) in a patient ratio of 1:3. Demographic data, symptoms, comorbidities, surgeries, endoscopy findings, medications, HbA1c, and TSH were analyzed. Univariate and multivariate logistic regression analyses were performed.

Results

A total of 808 patients were included, 202 patients with RGE and 606 patients with NGE. Mean gastric retention at 1 h was 18% [12.0, 24.0] and 65% [52.0, 76.0], respectively. Patient with RGE were more likely to present with nausea/vomiting (OR 2.4, p < 0.001), weight loss (OR 1.7, p = 0.008), and autonomic symptoms (OR 2.8, p = 0.022). Identified clinical predictors of RGE were older age (OR 1.08 [1.01, 1.1], p = 0.018), male gender (OR 2.0 [1.4, 2.9], p ≤ <0.001), higher BMI (OR 1.03 [1.00, 1.05], p = 0.018), diabetes (OR 1.8 [1.2, 2.7], p = 0.05), and fundoplication (OR 4.3 [2.4, 7.7], p ≤ 0.001).

Conclusion

RGE represents a distinct population among patients presenting with dyspepsia in whom fundoplication, diabetes, and male gender were the strongest clinical predictors. RGE was significantly associated with nausea/vomiting, weight loss, and autonomic symptoms.
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Metadaten
Titel
Clinical Predictors of Rapid Gastric Emptying in Patients Presenting with Dyspeptic Symptoms
verfasst von
Juan Gomez Cifuentes
Mark Radetic
Rocio Lopez
Scott Gabbard
Publikationsdatum
13.04.2019
Verlag
Springer US
Erschienen in
Digestive Diseases and Sciences / Ausgabe 10/2019
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-019-05620-8

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