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01.12.2011 | Review

Clinical relevance and biology of circulating tumor cells

Erschienen in: Breast Cancer Research | Ausgabe 6/2011

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Abstract

Most breast cancer patients die due to metastases, and the early onset of this multistep process is usually missed by current tumor staging modalities. Therefore, ultrasensitive techniques have been developed to enable the enrichment, detection, isolation and characterization of disseminated tumor cells in bone marrow and circulating tumor cells in the peripheral blood of cancer patients. There is increasing evidence that the presence of these cells is associated with an unfavorable prognosis related to metastatic progression in the bone and other organs. This review focuses on investigations regarding the biology and clinical relevance of circulating tumor cells in breast cancer.

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Titel: Clinical relevance and biology of circulating tumor cells
Publikationsdatum: 01.12.2011
Erschienen in: Breast Cancer Research / Ausgabe 6/2011
Elektronische ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr2940

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Clinical relevance and biology of circulating tumor cells

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Abstract

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