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Clinical Reviews in Allergy & Immunology

Clinical Reviews in Allergy & Immunology OnlineFirst articles


Current and Future Monoclonal Antibodies in the Treatment of Atopic Dermatitis

Atopic dermatitis is a common immunologic skin disease. Mild atopic dermatitis can be managed with emollients and topical therapies such as low potency topical steroids, which have a favorable safety profile. Severe atopic dermatitis, in contrast …


Treatments for Childhood Atopic Dermatitis: an Update on Emerging Therapies

Atopic dermatitis (AD) is generally considered a T helper type 2–dominated disease. Pediatric AD is usually less severe than adult AD, but it may present as moderate to severe lesions that are inadequately managed by current modalities including …


Type I Interferons in the Pathogenesis and Treatment of Autoimmune Diseases

Type I interferons (IFN-Is) are a very important group of cytokines that are produced by innate immune cells but also act on adaptive immune cells. IFN-Is possess antiviral, antitumor, and anti-proliferative effects, as well are associated with …


Chronic Granulomatous Disease: a Comprehensive Review

Chronic granulomatous disease (CGD) is a primary immunodeficiency of phagocyte function due to defective NADPH oxidase (phox). Compared with the common types of CYBB/gp91phox, NCF1/p47phox, and CYBA/p22phox deficiency, NCF4/p40phox deficiency is a …


Specialized Pro-Resolving Lipid Mediators: Emerging Therapeutic Candidates for Multiple Sclerosis

Multiple sclerosis (MS) is a neuroinflammatory disease in which unresolved and uncontrolled inflammation disrupts normal cellular homeostasis and leads to a pathological disease state. It has long been recognized that endogenously derived …

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The development of clinical allergy as a discipline of scientific medicine has, until recently, lagged behind that of other subspecialties in internal medicine and pediatrics. The discovery of immunoglobulin E, the development of standardized protocols for allergy skin testing and challenge procedures, and concurrent advances in cell biology have all led to a major thrust by new data in changing the approach to the clinical management of allergic disease. The object of this journal is to publish scholarly review papers, with each issue devoted to a single theme, in an attempt to provide comprehensive treatment of a subject of critical importance to allergists. The journal publishes both experimental papers and comprehensive treatises placing new data in perspective. The ultimate objective is to help improve the care and management of patients with allergic disease.

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