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Erschienen in: Journal of Clinical Immunology 4/2013

01.05.2013 | Original Research

Clinical Symptoms in Adults with Selective IgA Deficiency: A Case-Control Study

verfasst von: G. H. Jorgensen, A. Gardulf, M. I. Sigurdsson, S. Th. Sigurdardottir, I. Thorsteinsdottir, S. Gudmundsson, L. Hammarström, B. R. Ludviksson

Erschienen in: Journal of Clinical Immunology | Ausgabe 4/2013

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Abstract

Selective IgA deficiency (SIgAD) is the most common primary immunodeficiency in Caucasians with a prevalence of 1/600 and is generally considered a mild disorder. In this study, the clinical status of 32 adults with SIgAD was investigated and compared to 63 age- and gender matched controls, randomly selected from a population database. The SIgAD individuals reported significantly more often contracting various upper and lower respiratory infections, with 8 (25.0 %) having been diagnosed with ≥1 pneumonia in the preceding two years, compared to one (1.6 %) control (p < 0.001). Furthermore, the SIgAD individuals were found to have increased proneness to infections and increased prevalence of allergic diseases and autoimmunity, with a total of 84.4 % being affected by any of these diseases, compared to 47.6 % of the controls (p < 0.01). This study challenges the common statement of SIgAD being a mild form of immunodeficiency. It also highlights the importance of using matched controls in PID clinical research to better detect clinically important manifestations.
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Metadaten
Titel
Clinical Symptoms in Adults with Selective IgA Deficiency: A Case-Control Study
verfasst von
G. H. Jorgensen
A. Gardulf
M. I. Sigurdsson
S. Th. Sigurdardottir
I. Thorsteinsdottir
S. Gudmundsson
L. Hammarström
B. R. Ludviksson
Publikationsdatum
01.05.2013
Verlag
Springer US
Erschienen in
Journal of Clinical Immunology / Ausgabe 4/2013
Print ISSN: 0271-9142
Elektronische ISSN: 1573-2592
DOI
https://doi.org/10.1007/s10875-012-9858-x

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