Erschienen in:
01.05.2013 | Original Research
Clinical Symptoms in Adults with Selective IgA Deficiency: A Case-Control Study
verfasst von:
G. H. Jorgensen, A. Gardulf, M. I. Sigurdsson, S. Th. Sigurdardottir, I. Thorsteinsdottir, S. Gudmundsson, L. Hammarström, B. R. Ludviksson
Erschienen in:
Journal of Clinical Immunology
|
Ausgabe 4/2013
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Abstract
Selective IgA deficiency (SIgAD) is the most common primary immunodeficiency in Caucasians with a prevalence of 1/600 and is generally considered a mild disorder. In this study, the clinical status of 32 adults with SIgAD was investigated and compared to 63 age- and gender matched controls, randomly selected from a population database. The SIgAD individuals reported significantly more often contracting various upper and lower respiratory infections, with 8 (25.0 %) having been diagnosed with ≥1 pneumonia in the preceding two years, compared to one (1.6 %) control (p < 0.001). Furthermore, the SIgAD individuals were found to have increased proneness to infections and increased prevalence of allergic diseases and autoimmunity, with a total of 84.4 % being affected by any of these diseases, compared to 47.6 % of the controls (p < 0.01). This study challenges the common statement of SIgAD being a mild form of immunodeficiency. It also highlights the importance of using matched controls in PID clinical research to better detect clinically important manifestations.