Skip to main content
Erschienen in: Breast Cancer Research 2/2005

01.04.2005 | Commentary

Clinical trial update: National Cancer Institute of Canada

verfasst von: Kathy Pritchard, Tim Whelan

Erschienen in: Breast Cancer Research | Ausgabe 2/2005

Einloggen, um Zugang zu erhalten

Abstract

The Breast Cancer Site Group (BCSG) of the National Cancer Institute of Canada (NCIC) Clinical Trials Group (CTG) has conducted a wide variety of clinical trials focussing on large phase III trials of adjuvant chemotherapy, adjuvant hormonal therapy, and optimal delivery of adjuvant radiation therapy. The Group has also fostered, together with the NCIC CTG Investigational New Drug (IND) Program, a series of phase II and phase I/II studies which will be carried through if possible, into the phase III setting.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat Trudeau ME, Eisenhauer EA, Higgins B, Letendre F, Lofters WS, Norris B, Vandenberg T, Delorme F, Muldal A: Docetaxel in patients with metastic breast cancer: a phase II study of the National Cancer Institute of Canada-Clinical Trials Group. J Clin Oncol. 1996, 14: 422-428.CrossRefPubMed Trudeau ME, Eisenhauer EA, Higgins B, Letendre F, Lofters WS, Norris B, Vandenberg T, Delorme F, Muldal A: Docetaxel in patients with metastic breast cancer: a phase II study of the National Cancer Institute of Canada-Clinical Trials Group. J Clin Oncol. 1996, 14: 422-428.CrossRefPubMed
2.
Zurück zum Zitat Trudeau ME, Crump M, Latreille J, Pritchard KI, Palmer M, Tu D, Shepherd L, Shear N, Shapiro L, Oldfield S, et al: Escalating doses of docetaxel and epirubicin as first line therapy for metastatic breast cancer: a phase I/II study of the National Cancer Institute of Canada Clinical Trials Group [abstract]. Pro Am Soc Clin Oncol. 1999, 18: 117a- Trudeau ME, Crump M, Latreille J, Pritchard KI, Palmer M, Tu D, Shepherd L, Shear N, Shapiro L, Oldfield S, et al: Escalating doses of docetaxel and epirubicin as first line therapy for metastatic breast cancer: a phase I/II study of the National Cancer Institute of Canada Clinical Trials Group [abstract]. Pro Am Soc Clin Oncol. 1999, 18: 117a-
3.
Zurück zum Zitat Trudeau ME, Crump M, Latreille J, Pritchard KI, Palmer M, Tu D, Shepherd L, Shear N, Shapiro L, Oldfield S, et al: Escalating doses of docetaxel and epirubicin as first line therapy for metastatic breast cancer: A phase I/II study of the National Cancer Institute of Canada – Clinical Trials Group [abstract 443]. Proc Am Soc Clin Oncol. 1999, 18: 117a- Trudeau ME, Crump M, Latreille J, Pritchard KI, Palmer M, Tu D, Shepherd L, Shear N, Shapiro L, Oldfield S, et al: Escalating doses of docetaxel and epirubicin as first line therapy for metastatic breast cancer: A phase I/II study of the National Cancer Institute of Canada – Clinical Trials Group [abstract 443]. Proc Am Soc Clin Oncol. 1999, 18: 117a-
4.
Zurück zum Zitat Parissenti AM, Gannon BR, Villeneuve DJ, Kirwan-rhude AF, Chadderton A, Gluck S: Lack of modulation of MDR1 gene expression by dominant inhibition of cAMP-dependent protein kinase in doxorubicin-resistant MCF-7 breast cancer cells. Int J Cancer. 1999, 82: 893-900. 10.1002/(SICI)1097-0215(19990909)82:6<893::AID-IJC20>3.0.CO;2-8.CrossRefPubMed Parissenti AM, Gannon BR, Villeneuve DJ, Kirwan-rhude AF, Chadderton A, Gluck S: Lack of modulation of MDR1 gene expression by dominant inhibition of cAMP-dependent protein kinase in doxorubicin-resistant MCF-7 breast cancer cells. Int J Cancer. 1999, 82: 893-900. 10.1002/(SICI)1097-0215(19990909)82:6<893::AID-IJC20>3.0.CO;2-8.CrossRefPubMed
5.
Zurück zum Zitat Goss PE, Ingle JN, Martino S, Robert NJ, Muss HB, Piccart MJ, Castiglione M, Tu D, Shepherd L, Pater JL: Updated analysis of the NCIC CTG Ma.17 randomized placebo (P) controlled trial of letrozole (L) after five years of tamoxifen in postmenopausal women with early stage breast cancer [abstract. Proc Am Soc Clin Oncol. 2004, 22: 88s- Goss PE, Ingle JN, Martino S, Robert NJ, Muss HB, Piccart MJ, Castiglione M, Tu D, Shepherd L, Pater JL: Updated analysis of the NCIC CTG Ma.17 randomized placebo (P) controlled trial of letrozole (L) after five years of tamoxifen in postmenopausal women with early stage breast cancer [abstract. Proc Am Soc Clin Oncol. 2004, 22: 88s-
6.
Zurück zum Zitat Goss PE, Ingle JN, Martino S, Robert NJ, Muss HB, Piccart MJ, Castiglione M, Tu D, Shepherd L, Pritchard KI, et al: A randomized trial of letrozole in postmenopausal women after five years of tamoxifen therapy for early-stage breast cancer. N Eng J Med. 2003, 349: 1793-1802. 10.1056/NEJMoa032312.CrossRef Goss PE, Ingle JN, Martino S, Robert NJ, Muss HB, Piccart MJ, Castiglione M, Tu D, Shepherd L, Pritchard KI, et al: A randomized trial of letrozole in postmenopausal women after five years of tamoxifen therapy for early-stage breast cancer. N Eng J Med. 2003, 349: 1793-1802. 10.1056/NEJMoa032312.CrossRef
7.
Zurück zum Zitat The ATAC Trialists Group: Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: first results of the ATAC randomised trial. Lancet. 2002, 359: 2131-2139. 10.1016/S0140-6736(02)09088-8.CrossRef The ATAC Trialists Group: Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: first results of the ATAC randomised trial. Lancet. 2002, 359: 2131-2139. 10.1016/S0140-6736(02)09088-8.CrossRef
8.
Zurück zum Zitat The ATAC Trialists Group: Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early-stage breast cancer: results of the ATAC (Arimidex, Tamoxifen Alone or in Combination) trial efficacy and safety update analyses. Cancer. 2003, 98: 1802-1810. 10.1002/cncr.11745.CrossRef The ATAC Trialists Group: Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early-stage breast cancer: results of the ATAC (Arimidex, Tamoxifen Alone or in Combination) trial efficacy and safety update analyses. Cancer. 2003, 98: 1802-1810. 10.1002/cncr.11745.CrossRef
9.
Zurück zum Zitat Boccardo F, Rubagotti A, Amoroso D, Mesiti M, Massobrio M, Benedetto C, Porpiglia M, Rinaldini M, Paladini G, Distante V, et al: Anastrozole appears to be superior to tamoxifen in women already receiving adjuvant tamoxifen treatment. Breast Cancer Res Treat. 2004, 85: 192- Boccardo F, Rubagotti A, Amoroso D, Mesiti M, Massobrio M, Benedetto C, Porpiglia M, Rinaldini M, Paladini G, Distante V, et al: Anastrozole appears to be superior to tamoxifen in women already receiving adjuvant tamoxifen treatment. Breast Cancer Res Treat. 2004, 85: 192-
10.
Zurück zum Zitat Coombes RC, Hall E, Gibson L, Paridaens R, Jassem J, Delozier T, Jones SE, Alvarez I, Bertelli G, Ortmann O, et al: A randomized trial of exemestane after two to three years of tamoxifen therapy in postmenopausal women with primary breast cancer. N Eng J Med. 2004, 350: 1081-1091. 10.1056/NEJMoa040331.CrossRef Coombes RC, Hall E, Gibson L, Paridaens R, Jassem J, Delozier T, Jones SE, Alvarez I, Bertelli G, Ortmann O, et al: A randomized trial of exemestane after two to three years of tamoxifen therapy in postmenopausal women with primary breast cancer. N Eng J Med. 2004, 350: 1081-1091. 10.1056/NEJMoa040331.CrossRef
11.
Zurück zum Zitat Ragaz J, Stewart DJ, Le N, Plenderleith IH, Spinelli JJ, Basco VE, Wilson KS, Knowling MA, Coppin CM, Paradis M, et al: Adjuvant radiotherapy and chemotherapy in node-positive premenopausal women with breast cancer. N Engl J Med. 1997, 337: 956-962. 10.1056/NEJM199710023371402.CrossRefPubMed Ragaz J, Stewart DJ, Le N, Plenderleith IH, Spinelli JJ, Basco VE, Wilson KS, Knowling MA, Coppin CM, Paradis M, et al: Adjuvant radiotherapy and chemotherapy in node-positive premenopausal women with breast cancer. N Engl J Med. 1997, 337: 956-962. 10.1056/NEJM199710023371402.CrossRefPubMed
12.
Zurück zum Zitat Overgaard M, Hansen PS, Overgaard J, Rose C, Andersson M, Bach F, Kjaer M, Gadeberg CC, Mouridsen HT, Jensen MB, et al: Postoperative radiotherapy in high-risk premenopausal women with breast cancer who receive adjuvant chemotherapy. N Engl J Med. 1997, 337: 949-955. 10.1056/NEJM199710023371401.CrossRefPubMed Overgaard M, Hansen PS, Overgaard J, Rose C, Andersson M, Bach F, Kjaer M, Gadeberg CC, Mouridsen HT, Jensen MB, et al: Postoperative radiotherapy in high-risk premenopausal women with breast cancer who receive adjuvant chemotherapy. N Engl J Med. 1997, 337: 949-955. 10.1056/NEJM199710023371401.CrossRefPubMed
Metadaten
Titel
Clinical trial update: National Cancer Institute of Canada
verfasst von
Kathy Pritchard
Tim Whelan
Publikationsdatum
01.04.2005
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe 2/2005
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr979

Weitere Artikel der Ausgabe 2/2005

Breast Cancer Research 2/2005 Zur Ausgabe

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.