With the development of evidence-based medicine, clinical trials have become necessary for investigating and validating the efficacy of new treatments. Over the past 10 years, several clinical trials of new anticancer agents have been designed and launched in China; this has greatly promoted the development of novel agents as well as of innovative clinical study designs. However, despite the significant advances made in clinical trials for novel agents, improvements are still required. In this mini-review, we will summarize the ongoing clinical trials of small molecular inhibitors for the treatment of lung cancer in China, aiming specifically to highlight the active involvement of China in these clinical studies. Furthermore, we will discuss the urgent need for improvement of clinical trials and anticancer agent research in China.
Wu YL, Zhou Q, Liu XQ, Zhang L, Zhou JY, Wu L, et al. Phase I/II study of AC0010, mutant-selective EGFR inhibitor, in non-small cell lung cancer (NSCLC) patients with EGFR T790m mutation. J Thorac Oncol. 2017;12(Suppl 1):224–5.
Zhou Q, Gan B, Hong QY, Wang MZ, Liu XQ, Yuan LW, et al. A phase 1 dose expansion study of epitinib to evaluate efficacy and safety in EGFR mutation positive (EGFRm+) NCSLSC patients with brain metastasis. J Thorac Oncol. 2017;12(Suppl 1):122.
Wu YL, Yang JJ, Zhou CC, Feng JF, Lu S, Song Y, et al. BRAIN: a phase III trial comparing WBI and chemotherapy with icotinib in NSCLC with brain metastases harboring EGFR mutations (CTONG 1201). J Thorac Oncol. 2017;12(Suppl 1):3–4.
Wu YL. Phase II safety and efficacy results of a single-arm phase Ib/II study of capmatinib (INC280) + gefitinib in patients (pts) with EGFR-mutated (mut), cMET-positive (cMET+) non-small cell lung cancer (NSCLC). J Clin Oncol. 2016;34(Suppl 15):461.
Han BH, Li K, Zhao YZ, Wang QM, Zhang L, Shi JH, et al. A randomized phase III clinical trial of anlotinib hydrochloride in patients with advanced nonsmall cell lung cancer (NSCLC). J Thorac Oncol. 2017;12(Suppl 1):463–4.
Cao J, Zhang J, Peng W, Chen Z, Fan S, Su W, et al. A phase I study of safety and pharmacokinetics of fruquintinib, a novel selective inhibitor of vascular endothelial growth factor receptor-1, -2, and -3 tyrosine kinases in Chinese patients with advanced solid tumors. Cancer Chemother Pharmacol. 2016;78:259–69. CrossRefPubMed
Nogova L, Sequist LV, Perez Garcia JM, Andre F, Delord JP, Hidalgo M, et al. Evaluation of BGJ398, a fibroblast growth factor receptor 1-3 kinase inhibitor, in patients with advanced solid tumors harboring genetic alterations in fibroblast growth factor receptors: results of a global phase I, dose-escalation and dose-expansion study. J Clin Oncol. 2017;35:157–65. CrossRefPubMed
Zhou CC, Fan Y, Wang HJ, Liam CK, Hu CJ, Cseh A. Afatinib in patients with advanced HER2 mutation-positive NSCLC previously treated with chemotherapy. J Thorac Oncol. 2017;12(Suppl 1):564–5.
Goto K. Phase II study of crizotinib in East Asian patients (pts) with ROS1-positive advanced non-small cell lung cancer (NSCLC). J Clin Oncol. 2016;34(Suppl 15):461.
Zhou Q, Chen XY, Yang ZM, Wu YL. The changing landscape of clinical trial and approval processes in China. Nat Rev Clin Oncol. 2017; doi: 10.1038/nrclinonc.
Zhou Q. Liquid biopsy in monitoring dynamic changes of driver genes in advanced NSCLC. J Thorac Oncol. 2017;12(Suppl 1):120.
- Clinical trials of tyrosine kinase inhibitors for lung cancer in China: a review
- BioMed Central
Neu im Fachgebiet Onkologie
Mail Icon II