Skip to main content
Erschienen in: Journal of NeuroVirology 5/2021

01.10.2021

Clinical use of steroids in viral central nervous system (CNS) infections: three challenging cases

verfasst von: Adam Kroopnick, Dan Tong Jia, Kathryn Rimmer, Vivian S. Namale, Carla Kim, Ugoada Ofoezie, Kiran T. Thakur

Erschienen in: Journal of NeuroVirology | Ausgabe 5/2021

Einloggen, um Zugang zu erhalten

Abstract

The role of adjunctive corticosteroids in reducing morbidity and mortality of viral CNS infections remains poorly defined. Clinicians are often left in a quagmire regarding steroid use in complex and rapidly evolving viral CNS infections. Limited studies have explored the underlying mechanisms behind the potential benefit of steroids. Here, we describe steroid use in three cases of viral CNS disease: varicella zoster virus (VZV), Powassan virus, and influenza A-associated acute necrotizing encephalopathy.
Literatur
Zurück zum Zitat Deigendesch N, Stenzel W (2018) Acute and chronic viral infections. In: Kovacs GG, Alafuzoff I (eds). Handb Clin Neurol Camb pp 227–243 Deigendesch N, Stenzel W (2018) Acute and chronic viral infections. In: Kovacs GG, Alafuzoff I (eds). Handb Clin Neurol Camb pp 227–243
Zurück zum Zitat Martinez-Torres F, Menon S, Pritsch M, Victor N, Jenetzky E, Jensen K, Schielke E, Schmutzhard E, de Gans J, Chung CH, Luntz S, Hacke W, Meyding-Lamade U, GACHE Investigators (2008) Protocol for German trial of acyclovir and corticosteroids in herpes-simplex-virus-encephalitis (GACHE): a multicenter, multinational, randomized, double-blind, placebo-controlled German, Austrian and Dutch trial [ISRCTN45122933]. BMC Neurol 8:40. https://doi.org/10.1186/1471-2377-8-40CrossRefPubMedPubMedCentral Martinez-Torres F, Menon S, Pritsch M, Victor N, Jenetzky E, Jensen K, Schielke E, Schmutzhard E, de Gans J, Chung CH, Luntz S, Hacke W, Meyding-Lamade U, GACHE Investigators (2008) Protocol for German trial of acyclovir and corticosteroids in herpes-simplex-virus-encephalitis (GACHE): a multicenter, multinational, randomized, double-blind, placebo-controlled German, Austrian and Dutch trial [ISRCTN45122933]. BMC Neurol 8:40. https://​doi.​org/​10.​1186/​1471-2377-8-40CrossRefPubMedPubMedCentral
Zurück zum Zitat Nagel MA, Cohrs RJ, Mahalingam R, Wellish MC, Forghani B, Schiller A, Safdieh JE, Kamenkovich E, Ostrow LW, Levy M, Greenberg B, Russman AN, Katzan I, Gardner CJ, Hausler M, Nau R, Saraya T, Wada H, Goto H, de Martino M, Ueno M, Brown WD, Terborg C, Gilden DH (2008) The varicella zoster virus vasculopathies: clinical, CSF, imaging, and virologic features. Neurology 70:853–860. https://doi.org/10.1212/01.wnl.0000304747.38502.e8CrossRef Nagel MA, Cohrs RJ, Mahalingam R, Wellish MC, Forghani B, Schiller A, Safdieh JE, Kamenkovich E, Ostrow LW, Levy M, Greenberg B, Russman AN, Katzan I, Gardner CJ, Hausler M, Nau R, Saraya T, Wada H, Goto H, de Martino M, Ueno M, Brown WD, Terborg C, Gilden DH (2008) The varicella zoster virus vasculopathies: clinical, CSF, imaging, and virologic features. Neurology 70:853–860. https://​doi.​org/​10.​1212/​01.​wnl.​0000304747.​38502.​e8CrossRef
Zurück zum Zitat Piantadosi A, Rubin DB, McQuillen DP, Hsu L, Lederer PA, Ashbaugh CD, Duffalo C, Duncan R, Thon J, Bhattacharyya S, Basgoz N, Feske SK, Lyons JL (2016) Emerging cases of Powassan virus encephalitis in New England: clinical presentation, imaging, and review of the literature. Clin Infect Dis 62:707–713. https://doi.org/10.1093/cid/civ1005CrossRefPubMed Piantadosi A, Rubin DB, McQuillen DP, Hsu L, Lederer PA, Ashbaugh CD, Duffalo C, Duncan R, Thon J, Bhattacharyya S, Basgoz N, Feske SK, Lyons JL (2016) Emerging cases of Powassan virus encephalitis in New England: clinical presentation, imaging, and review of the literature. Clin Infect Dis 62:707–713. https://​doi.​org/​10.​1093/​cid/​civ1005CrossRefPubMed
Zurück zum Zitat Tunkel AR, Glaser CA, Bloch KC, Sejvar JJ, Marra CM, Roos KL, Hartman BJ, Kaplan SL, Scheld WM, Whitley RJ, Infectious Diseases Society of America (2008) The management of encephalitis: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis 47:303–327. https://doi.org/10.1086/589747CrossRef Tunkel AR, Glaser CA, Bloch KC, Sejvar JJ, Marra CM, Roos KL, Hartman BJ, Kaplan SL, Scheld WM, Whitley RJ, Infectious Diseases Society of America (2008) The management of encephalitis: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis 47:303–327. https://​doi.​org/​10.​1086/​589747CrossRef
Metadaten
Titel
Clinical use of steroids in viral central nervous system (CNS) infections: three challenging cases
verfasst von
Adam Kroopnick
Dan Tong Jia
Kathryn Rimmer
Vivian S. Namale
Carla Kim
Ugoada Ofoezie
Kiran T. Thakur
Publikationsdatum
01.10.2021
Verlag
Springer International Publishing
Erschienen in
Journal of NeuroVirology / Ausgabe 5/2021
Print ISSN: 1355-0284
Elektronische ISSN: 1538-2443
DOI
https://doi.org/10.1007/s13365-021-01008-5

Weitere Artikel der Ausgabe 5/2021

Journal of NeuroVirology 5/2021 Zur Ausgabe

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.