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06.04.2018 | Head and Neck | Ausgabe 6/2018

European Archives of Oto-Rhino-Laryngology 6/2018

Clinical utility of dynamic-enhanced MRI in salivary gland tumors: retrospective study and literature review

Zeitschrift:
European Archives of Oto-Rhino-Laryngology > Ausgabe 6/2018
Autoren:
Takenori Ogawa, Ikuho Kojima, Ryo Ishii, Maya Sakamoto, Takaki Murata, Takahiro Suzuki, Kengo Kato, Ayako Nakanome, Akira Ohkoshi, Eiichi Ishida, Seiji Kakehata, Kiyoto Shiga, Yukio Katori
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s00405-018-4965-9) contains supplementary material, which is available to authorized users.

Abstract

Purpose

To improve the diagnoses of the salivary gland tumors, a dynamic-enhanced MRI (dMRI) was investigated.

Methods

We conducted a retrospective chart review of 93 cases of salivary gland tumors. The histological diagnoses were obtained from all patients using a surgical specimen and/or an open biopsy specimen. The dMRI as well as fine-needle aspiration cytology (FNAC) and intraoperative frozen section (IFS) were analyzed. This study focused on the time-intensity curve (TIC) after injection, peak time (Tpeak), washout ratio (WR) as well as the gradient of enhancement and washout profile.

Results

The histological diagnoses included pleomorphic adenoma (PMA) in 53 cases, the Warthin tumors (WT) in 14 cases and malignant tumors (MT) in 26 cases. Incorrect diagnosis rate of FNAC and IFS were 5.2 and 8.3%, respectively. The TIC revealed differences among the three types of tumors. Tpeak as well as WR also revealed significant differences (p < 0.001). Tpeak were lower in order of WT, MT, PMA, respectively. WR of TICs at 30, 45 and 105 s after Tpeak were higher in order of WT, MT, PMA, respectively (p < 0.001). The gradient of increment and washout in the TIC curve was also an important parameter to distinguish the three types of tumors. In MT, the rapid enhancement pattern was found in high or intermediate histological grade tumors, whereas the slow enhancement pattern was exhibited in low grade tumors.

Conclusions

Our findings indicate that using Tpeak and WR, it is possible to distinguish between WT, PMA and MT. Additionally, a rapid enhancement pattern may be a potential marker for these tumors.

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Zusatzmaterial
Supplementary material 1 Supplementary fig. 1: The box and whisker plot of TICs. a: 15 sec, b: 45 sec, c: 75 sec, d:105 sec. Maximum number, 25% percentile, median, 75% percentile and minimum number were shown in box and whisker plot. *: p&#x003C;0.01, * *: p&#x003C;0.05. Supplementary fig. 2: WR of TICs. a: 30 sec, b: 45 sec, c: 105 sec after Tpeak. *: p&#x003C;0.001 (PPTX 119 KB)
405_2018_4965_MOESM1_ESM.pptx
Literatur
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