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Erschienen in: Breast Cancer Research and Treatment 2/2019

22.04.2019 | Epidemiology

Clinico-pathologic and mammographic characteristics of inflammatory and non-inflammatory breast cancer at six centers in North Africa

verfasst von: Catherine Schairer, Ahmed Hablas, Ibrahim AbdelBar Seif Eldein, Rabab Gaafar, Henda Rais, Amel Mezlini, Farhat Ben Ayed, Wided Ben Ayoub, Abdellatif Benider, Ali Tahri, Mouna Khouchani, Dalia Aboulazm, Mehdi Karkouri, Saad Eissa, Ruth M. Pfeiffer, Shahinaz M. Gadalla, Sandra M. Swain, Sofia D. Merajver, Linda Morris Brown, Amr S. Soliman

Erschienen in: Breast Cancer Research and Treatment | Ausgabe 2/2019

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Abstract

Purpose

We describe the clinico-pathologic and mammographic characteristics of inflammatory breast cancer (IBC) and non-IBC cases enrolled in a case–control study. Because IBC is a clinico-pathologic entity with rapid appearance of erythema and other signs, its diagnosis is based on clinical observation and thus, by necessity, subjective. Therefore, we evaluate our cases by photographic review by outside expert clinicians and by degree of adherence to the two most recent definitions of IBC: the international expert panel consensus statement and American Joint Committee on Cancer (AJCC) 8th edition (we used the slightly less restrictive 7th edition definition for our study).

Methods

We enrolled 267 IBC and 274 age- and geographically matched non-IBC cases at 6 sites in Egypt, Tunisia, and Morocco in a case–control study of IBC conducted between 2009 and 2015. We collected clinico-pathologic and mammographic data and standardized medical photographs of the breast.

Results

We identified many differences between IBC and non-IBC cases: 54.5% versus 68.8% were estrogen receptor-positive, 39.9% versus 14.8% human epidermal growth factor receptor 2-positive, 91% versus 4% exhibited erythema, 63% versus 97% had a mass, and 57% versus 10% had mammographic evidence of skin thickening. Seventy-six percent of IBC cases adhered to the expert panel consensus statement and 36% to the AJCC definition; 86 percent were confirmed as IBC by either photographic review or adherence to the consensus statement.

Conclusions

We successfully identified distinct groups of IBC and non-IBC cases. The reliability of IBC diagnosis would benefit from expert review of standardized medical photographs and associated clinical information.
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Metadaten
Titel
Clinico-pathologic and mammographic characteristics of inflammatory and non-inflammatory breast cancer at six centers in North Africa
verfasst von
Catherine Schairer
Ahmed Hablas
Ibrahim AbdelBar Seif Eldein
Rabab Gaafar
Henda Rais
Amel Mezlini
Farhat Ben Ayed
Wided Ben Ayoub
Abdellatif Benider
Ali Tahri
Mouna Khouchani
Dalia Aboulazm
Mehdi Karkouri
Saad Eissa
Ruth M. Pfeiffer
Shahinaz M. Gadalla
Sandra M. Swain
Sofia D. Merajver
Linda Morris Brown
Amr S. Soliman
Publikationsdatum
22.04.2019
Verlag
Springer US
Erschienen in
Breast Cancer Research and Treatment / Ausgabe 2/2019
Print ISSN: 0167-6806
Elektronische ISSN: 1573-7217
DOI
https://doi.org/10.1007/s10549-019-05237-5

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