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Erschienen in: Japanese Journal of Ophthalmology 4/2016

16.05.2016 | Clinical Investigation

Clinico-radiological features of primary lacrimal gland pleomorphic adenoma: an analysis of 37 cases

verfasst von: Akihide Watanabe, Nicholas H. Andrew, Kosuke Ueda, Shigeru Kinoshita, Nobutada Katori, Michael Reid, Adnan Pirbhai, Dinesh Selva

Erschienen in: Japanese Journal of Ophthalmology | Ausgabe 4/2016

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Abstract

Purpose

To present the radiological and clinical features of primary lacrimal gland pleomorphic adenoma (PLGPA).

Methods

Thirty-seven consecutive PLGPAs presenting to two hospitals in Japan were reviewed.

Results

PLGPA cases had 15 men and 22 women with a mean age of 51.9 years. Common presenting features were ptosis (83 %), diplopia (78 %) and globe displacement (78 %). Twenty-two percent of cases reported symptom duration of less than 6 months, but only 5.6 % of cases had pain. Sixteen percent of PLGPAs were centered in the palpebral lobe; none of which were associated with globe indentation or lacrimal fossa expansion. Bony excavation was observed in 84 % of orbital lobe PLGPA; the bone margin was well demarcated and the character of excavation was more frequently smooth than scalloped (2:1). The presence of globe indentation or bony excavation was associated with increased tumor size (p = 0.003). An enhancing rim was visible on T1-weighted fat-suppressed gadolinium-enhanced magnetic resonance imaging (T1FS-Gad MRI) in 27 %. Five (19 %) enclosed cystic spaces were bright on T2-weighted MRI and non-enhancing. Calcification of tumor parenchyma was common in cystic cases but rare in non-cystic cases (p = 0.01).

Conclusions

PLGPAs have varied clinical and radiological features. Common radiological features are a heterogeneous internal architecture on T2-weighted MRI, an enhancing rim on T1FS-Gad MRI, smooth or scalloped bony excavation with intact cortical bone, and globe indentation. Cystic spaces, calcification, and symptom duration less than 6 months are common, but pain is rare. Awareness of the clinico-radiological variants of PLGPA is important when considering incisional biopsy of a lacrimal gland mass.
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Metadaten
Titel
Clinico-radiological features of primary lacrimal gland pleomorphic adenoma: an analysis of 37 cases
verfasst von
Akihide Watanabe
Nicholas H. Andrew
Kosuke Ueda
Shigeru Kinoshita
Nobutada Katori
Michael Reid
Adnan Pirbhai
Dinesh Selva
Publikationsdatum
16.05.2016
Verlag
Springer Japan
Erschienen in
Japanese Journal of Ophthalmology / Ausgabe 4/2016
Print ISSN: 0021-5155
Elektronische ISSN: 1613-2246
DOI
https://doi.org/10.1007/s10384-016-0451-3

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