Background
Methods
Patients and tissue specimen
Immunohistochemical analysis
RNA preparation and quantitative RT-PCR
Western blotting analysis
Statistical analysis
Results
GPX2 protein was overexpressed within ESCC tumour tissues
Expression of GPX2 protein significantly correlated with tumour histological grade of ESCC
Clinical features | Cases | GPX2+ | GPX2− | P value |
---|---|---|---|---|
Age | ||||
≤ 58 years | 83 | 70 | 13 | 0.539 |
> 58 years | 78 | 62 | 16 | |
Sex | ||||
Male | 117 | 95 | 22 | 0.670 |
Female | 44 | 37 | 7 | |
Size | ||||
≤ 4.5 cm | 98 | 83 | 15 | 0.265 |
> 4.5 cm | 63 | 49 | 14 | |
Site | ||||
Upper | 13 | 12 | 1 | 0.380 |
Middle | 107 | 89 | 18 | |
Below | 41 | 31 | 10 | |
Gross morphology | ||||
Medullary | 79 | 69 | 10 | 0.258 |
Umbrella | 11 | 9 | 2 | |
Ulcer | 54 | 40 | 14 | |
Stenosis | 17 | 14 | 3 | |
Histological grade | ||||
I | 46 | 41 | 5 | <0.001 |
II | 94 | 86 | 8 | |
III | 21 | 5 | 16 | |
TNM stages | ||||
I~II | 86 | 75 | 11 | 0.118 |
III | 73 | 55 | 18 | |
IV | 2 | 2 | 0 |
Negatively-expression of GPX2 protein predicted a poorer prognosis in ESCC patients
Clinical features | Cases | Mortality | MST (95 % CI) | Log-rank P value | HR (95 % CI) |
---|---|---|---|---|---|
Age | |||||
≤ 58 years | 45 | 35 | 26 (16.141~38.859) | 0.850 | 1.049 (0.637~1.725) |
> 58 years | 38 | 28 | 18 (5.918~30.082) | ||
Sex | |||||
Male | 60 | 46 | 26 (13.348~38.652) | 0.796 | 1.075 (0.616~1.876) |
Female | 23 | 17 | 18 (8.609~27.391) | ||
Size | |||||
≤ 4.5 cm | 48 | 35 | 29 (17.118~40.882) | 0.339 | 1.270 (0.772~2.088) |
> 4.5 cm | 35 | 28 | 19 (4.512~33.488) | ||
Site | |||||
Upper | 9 | 6 | 33 (0~73.905) | 0.028 | 1.803 (0.992~3.278) |
Middle | 65 | 48 | 29 (18.467~39.533) | ||
Below | 9 | 9 | 11 (5.156~16.844) | ||
Gross morphology | |||||
Medullary | 62 | 46 | 30 (9.755~50.245) | <0.001 | 1.252 (0.942~1.663) |
Umbrella | 5 | 4 | 9 (6.853~11.147) | ||
Ulcer | 13 | 10 | 20 (10.605~29.395) | ||
Stenosis | 3 | 3 | 6 (4.400~7.600) | ||
Histological grade | |||||
I | 32 | 20 | 47 (10.966~83.034) | 0.009 | 1.885 (1.212~2.932) |
II | 46 | 38 | 20 (8.616~31.384) | ||
III | 5 | 5 | 8 (5.853~10.147) | ||
TNM stages | |||||
I~II | 49 | 32 | 42 (22.796~61.204) | 0.007 | 2.046 (1.318~3.177) |
III | 32 | 29 | 14 (6.608~21.392) | ||
IV | 2 | 2 | - | ||
Treatment | |||||
No | 41 | 31 | 19 (3.944~34.056) | 0.529 | 0.855 (0.522~1.402) |
Yes | 42 | 32 | 22 (10.886~33.114) |
GPX2 | Cases | Death | MST (95 % CI) | One-year survival rate (%) | χ2 value | Log-rank P value |
---|---|---|---|---|---|---|
+ | 76 | 56 | 29 (15.117~42.883) | 71.1 | 22.587 | <0.001 |
− | 7 | 7 | 8 (5.434~10.566) | 0 |
Variable | B | SE (B) | Wald χ2 | P value | HR | HR 95 % CI |
---|---|---|---|---|---|---|
GPX2 | 1.741 | 0.455 | 14.630 | <0.001 | 5.700 | 2.337~13.907 |
Histological grade | 0.553 | 0.214 | 6.688 | 0.010 | 1.739 | 1.143~2.646 |